Altered host immunity, human T lymphotropic virus type I replication, and risk of adult T-cell leukemia/lymphoma: a prospective analysis from the ATL Cohort Consortium

Abstract

Birmann et al.: Altered host immunity, human T lymphotropic virus type I replication, and risk of adult T-cell leukemia/ lymphoma: a prospective analysis from the ATL Cohort Consortium.

Adult T-Cell Leukemia: A Review of Epidemiological Evidence

“…A series of the Miyazaki Cohort Study (population size; 1,960 people, of whom 27% were HTLV-1 antibody-positive) reported that an HTLV-1 carrier with a high anti-HTLV-1 titer (odds ratio; 1.6), a high number of circulating abnormal lymphocytes, and a low anti-Tax reactivity were associated with a greater risk of developing ATL (Mueller et al, 1996 ; Hisada et al, 1998a , b ). Recently, an international ATL Cohort Consortium study by merging eight cohorts from Japan, Jamaica, the United States, and Brazil examined serologic markers of HTLV-I pathogenesis and host immunity in 53 ATL cases and 150 matched asymptomatic HTLV-I carriers (Birmann et al, 2011 ). The study confirmed that above-median sIL-2R and anti-Tax seropositivity were independently associated with an increased ATL risk, and found that above-median total immunoglobulin E levels predicted a lower ATL risk.…”

Conference highlights of the 15th international conference on human retrovirology: HTLV and related retroviruses, 4-8 june 2011, Leuven, Gembloux, Belgium

“…A multicenter collaborative investigation of biomarkers which might predict ATL was reported by Birmann et al . [ 10 ]. A total of 53 incident ATL cases and 150 carefully matched asymptomatic HTLV-1 carriers were obtained from population-based studies in Japan, Jamaica, the United States of America, and Brazil, and multiple biomarkers were measured on PBMCs and serum.…”