Altered functional connectivity in binge eating disorder and bulimia nervosa: A resting‐state fMRI study

Stopyra, Marion A.; Simon, Joe J.; Skunde, Mandy; Walther, Stephan; Bendszus, Martin; Herzog, Wolfgang; Friederich, Hans‐Christoph

doi:10.1002/brb3.1207

Cited by 49 publications

(49 citation statements)

References 76 publications

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“…To date, only 11 studies have examined the relationship between functional network organization and clinical eating phenotypes most typically associated with obesity. Of these, only two studies included individuals with a BMI in the overweight or obese range ( Geliebter et al , 2016 ; Stopyra et al , 2019 ). Further, very little is known about functional network organization in BED, the eating disorder most frequently co-occurring with obesity.…”

Section: Relationship Between Disordered Eating Behaviors and Functiomentioning

confidence: 99%

“…This suggests that regions involved in body awareness and sensation might be more integrated in BN, which may be associated with body image distortions and enhanced responsiveness to food cues. Similarly, BED has also been linked to enhanced resting connectivity between regions of somatosensory cortex ( Stopyra et al, 2019 ). Moreover, the strength of connectivity was positively correlated with the frequency of binge episodes ( Stopyra et al, 2019 ), providing evidence that stronger coupling of these regions represents a neural signature of binge eating.…”

Section: Relationship Between Disordered Eating Behaviors and Functiomentioning

confidence: 99%

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A review of the relationship between eating behavior, obesity and functional brain network organization

Donofry

Stillman

Erickson

2019

Social Cognitive and Affective Neuroscience

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Abstract Obesity is a major public health issue affecting nearly 40% of American adults and is associated with increased mortality and elevated risk for a number of physical and psychological illnesses. Obesity is associated with impairments in executive functions such as decision making and inhibitory control, as well as in reward valuation, which is thought to contribute to difficulty sustaining healthy lifestyle behaviors, including adhering to a healthy diet. Growing evidence indicates that these impairments are accompanied by disruptions in functional brain networks, particularly those that support self-regulation, reward valuation, self-directed thinking and homeostatic control. Weight-related differences in task-evoked and resting-state connectivity have most frequently been noted in the executive control network (ECN), salience network (SN) and default mode network (DMN), with obesity generally being associated with weakened connectivity in the ECN and enhanced connectivity in the SN and DMN. Similar disruptions have been observed in the much smaller literature examining the relationship between diet and disordered eating behaviors on functional network organization. The purpose of this narrative review was to summarize what is currently known about how obesity and eating behavior relate to functional brain networks, describe common patterns and provide recommendations for future research based on the identified gaps in knowledge.

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Section: Relationship Between Disordered Eating Behaviors and Functiomentioning

confidence: 99%

Section: Relationship Between Disordered Eating Behaviors and Functiomentioning

confidence: 99%

A review of the relationship between eating behavior, obesity and functional brain network organization

Donofry

Stillman

Erickson

2019

Social Cognitive and Affective Neuroscience

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“…On the other hand, BED showed higher connectivity values in the right cerebellum and right lingual gyrus compared with HC. When comparing BN and BED directly, BED showed a higher connectivity in posterior dorsal cingulate cortex, but lower connectivity in the middle frontal gyrus and angular gyrus (Stopyra et al, 2019). To summarize, BN and BED showed less connectivity in the salience network (aDCC, dACC), higher connectivity in the default mode network, but only in BN (dorsal mPFC, lateral ventral mPFC), and both higher and lower connectivity in the executive network (middle frontal gyrus, angular gyrus, inferior parietal cortex).…”

Section: Functional Connectivitymentioning

confidence: 94%

“…Functional connectivity changes (see Table 1 functional connectivity) largely overlap with the structural connectivity changes discussed above (section 2.2). A large study determining differences in functional connectivity in BED and BN compared with HC (Stopyra et al, 2019) showed lower connectivity in the anterior part of the dorsal cingulate cortex (aDCC), the dorsal part of the anterior cingulate cortex (dACC), and inferior parietal cortex in BED and BN. BED showed lower connectivity within the dorsal medial prefrontal cortex, whilst it was higher in BN compared with HC.…”

Section: Functional Connectivitymentioning

confidence: 99%

Volumetric and connectivity changes in brain networks associated with reward sensitivity, cognitive control, and negative affect in binge eating disorder and bulimia nervosa

Hartogsveld¹,

Cw²,

P³

et al. 2020

Preprint

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Binging disorders are characterized by episodes of eating large amounts of food whilst experiencing a loss of control. Recent studies suggest that the underlying causes of these binging disorders consist of a complex system of environmental cues, different processing of food stimuli, altered behavioral responding, and brain changes. We propose that task-independent volumetric and connectivity changes in the brain are highly related to altered functioning in reward sensitivity, cognitive control, and negative affect, which in turn promotes and conserves binging behavior. We here review imaging studies and show that volume and connectivity changes in the orbitofrontal cortex, inferior frontal gyrus, medial prefrontal cortex, striatum, insula and amygdala overlap with distorted brain activation associated with increased reward sensitivity, decreased cognitive control, and distorted responses to negative affect or stress seen in binging disorder. Future research integrating both task-based and task-independent neuroimaging approaches therefore shows considerable promise in clarifying binging behavior. We provide suggestions for how this integration may guide future research and inform novel brain-based treatment options in binging disorders.

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“…This approach aims to identify taskindependent and more fundamental functional patterns underlying different states and/or disorders (Fox & Greicius, 2010). RsfMRI has been adopted to describe functional connectivity in relation to eating and weight disorders (García-García et al, 2015;Stopyra et al, 2019), and preliminary evidence converges in identifying altered functional connectivity patterns in regions mainly implicated in impulsivity-related aspects (such as, prefrontal, subcortical and parietal regions) in overeating conditions (García-García et al, 2015;Moreno-Lopez, Contreras-Rodriguez, Soriano-Mas, Stamatakis, & Verdejo-Garcia, 2016;Park, Seo, & Park, 2016). For example, functional connectivity changes within the frontoparietal circuit have been linked to disinhibited eating behavior (as assessed by Three Factor Eating Questionnaire, TFEQ; Stunkard & Messick, 1985) and body mass index (BMI) in normal-and overweight individuals (Park et al, 2016).…”

Section: Resting-state Fmri Investigations Of Binge Eatingmentioning

confidence: 99%

Characterizing impulsivity and resting‐state functional connectivity in normal‐weight binge eaters

Oliva

Morys

Horstmann

et al. 2019

Intl J Eating Disorders

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Objective Binge eating is characterized by episodes of uncontrolled eating, within discrete periods of time. Although it is usually described in obese individuals or as a symptom of Binge Eating Disorder (BED), this behavior can also occur in the normal‐weight (NW) population. An interesting premise suggests that impulsivity might contribute to the onset of binge eating and the progression toward weight gain. Drawing upon this evidence, here we explored impulsivity in NW individuals reporting binge‐eating episodes through a functional connectivity approach. We hypothesized that, even in the absence of an eating disorder, NW binge eaters would be characterized by connectivity pattern changes in corticostriatal regions implicated in impulsivity, similarly to the results described in BED individuals. Methods A resting‐state functional magnetic resonance imaging study tested 39 NW men and women, with and without binge eating (binge eaters, BE and non‐BE). Brain functional connectivity was explored by means of graph theoretic centrality measures and traditional seed‐based analysis; trait impulsivity was assessed with self‐report questionnaires. Results The BE group was characterized by a higher degree of trait impulsivity. Brain functional connectivity measures revealed lower degree centrality within the right middle frontal gyrus, left insula/putamen and left temporoparietal regions and a lower functional connectivity between the right middle frontal gyrus and right insula in the BE group. Discussion The results support previous evidence on BED of altered functional connectivity and higher impulsivity at the roots of overeating behavior, but further extend this concept excluding any potential confounding effect exerted by the weight status.

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Altered functional connectivity in binge eating disorder and bulimia nervosa: A resting‐state fMRI study

Cited by 49 publications

References 76 publications

A review of the relationship between eating behavior, obesity and functional brain network organization

A review of the relationship between eating behavior, obesity and functional brain network organization

Volumetric and connectivity changes in brain networks associated with reward sensitivity, cognitive control, and negative affect in binge eating disorder and bulimia nervosa

Characterizing impulsivity and resting‐state functional connectivity in normal‐weight binge eaters

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