Altered feeding behaviour induced by long-term cisplatin in rats

Augmented antitumor effects of combination therapy of cisplatin with ethaselen as a novel thioredoxin reductase inhibitor on human A549 cell in vivo

“…Mice in the cisplatin 2.5 mg/kg treated group had more serious side effects than other groups ( Fig. 1c-3, Tables 2, 3) including body weight decline, increases in BUN, Cre, ALT and AST, and histological changes in kidney and liver, that are consistent with results published by other groups [48]. The same results were not observed in the ethaselen alone and combination therapy group.…”

WIN 55,212-2 prevents mechanical allodynia but not alterations in feeding behaviour induced by chronic cisplatin in the rat

“…At this dose, cisplatin has been reported to induce pica (Yamamoto et al, 2004). However, in our hands, induction of significant pica requires the use of higher doses, if a single administration of cisplatin is applied (unpublished observations), or chronic administration of this dose (and even then significance is reached only occasionally, see Vera et al, 2006). Inconsistency of results when using this low dose of the antineoplastic drug could be related to differences in the experimental approach (e.g., animals used, preparation of kaolin, precise composition of food or drinking water).…”

“…Therefore, rats were distributed in eight different experimental groups, as shown in Table 1. Drug doses were selected according to references found in the literature and our own experience (Authier et al, 2003a;Vera et al, 2006;Pascual et al, 2005). Drug volumes were adjusted to a maximum of 4-5 ml kg − 1 .…”

“…It is amongst the most emetogenic antitumoral drugs (Jordan et al, 2005) and serves as reference for the study of antiemetics in experimental animals (Andrews and Horn, 2006). In the rat, which does not vomit in response to emetogenic stimuli, cisplatin induces an alteration of feeding behaviour called pica, consisting of the ingestion of non-nutritive substances, i.e., kaolin (Mitchell et al, 1976;Takeda et al, 1993Takeda et al, , 1995aVera et al, 2006). Recently, we have used the pica model to study the effect of low doses of cisplatin chronically administered, in an attempt to better mimic the clinical situation .…”

The Effects of Dokhwaljihwang-tang Intravenous Pharmacopuncture on Cisplatin-Induced Emesis and Gastrointestinal Mobility Disorder in Rats

“…In rats, this behavior is known to be related to the gastrointestinal vagus nerve 28) . In rats injected with cisplatin, the intake of kaolin increases; therefore, kaolin is used as an indirect indicator of rat nausea and vomiting 29) .…”