Altered expression of long non-coding RNA and mRNA in mouse cortex after traumatic brain injury

Zhong, Jian; Jiang, Li; Cheng, Chung–Ying; Huang, Zhijian; Zhang, Hongrong; Liu, Han; He, Junchi; Cao, Fang; Peng, Jianhua; Jiang, Yong; Sun, Xiaochuan

doi:10.1016/j.brainres.2016.07.002

Cited by 67 publications

(51 citation statements)

References 53 publications

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“…Studies have shown that TBI results in the altered expression of protein-coding genes involved in inflammatory responses, apoptosis, oxidative stress, metabolism, cellular repair and plasticity [116][117][118][119]. A previous study demonstrated that the expression of both protein-coding and lncRNA genes was altered near the injury site in the mouse cerebral cortex 24 h after TBI [120]. Through the analysis of co-expression networks, Zhong et al inferred that lncRNAs with significantly altered expression were related to biological functions relevant to TBI, such as inflammatory response, metabolism and apoptosis.…”

Section: Traumatic Brain Injurymentioning

confidence: 99%

Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Durán

Wei

Kim

et al. 2019

Neuropathology Appl Neurobio

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Genome‐wide transcriptional studies have demonstrated that tens of thousands of long non‐coding RNAs (lncRNA) genes are expressed in the central nervous system (CNS) and that they exhibit tissue‐ and cell‐type specificity. Their regulated and dynamic expression and their co‐expression with protein‐coding gene neighbours have led to the study of the functions of lncRNAs in CNS development and disorders. In this review, we describe the general characteristics, localization and classification of lncRNAs. We also elucidate the examples of the molecular mechanisms of nuclear and cytoplasmic lncRNA actions in the CNS and discuss common experimental approaches used to identify and unveil the functions of lncRNAs. Additionally, we provide examples of lncRNA studies of cell differentiation and CNS disorders including CNS injuries and neurodegenerative diseases. Finally, we review novel lncRNA‐based therapies. Overall, this review highlights the important biological roles of lncRNAs in CNS functions and disorders.

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Section: Traumatic Brain Injurymentioning

confidence: 99%

Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Durán

Wei

Kim

et al. 2019

Neuropathology Appl Neurobio

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“…A recent study showed the expression of several lncRNAs was altered in mouse cerebral cortex at 24h after TBI (Zhong et al, 2016). This study also evaluated the effect of TBI on mRNA expression simultaneously.…”

Section: Other Non-coding Rnas Altered Following Acute Cns Injuriesmentioning

confidence: 99%

“…This study also evaluated the effect of TBI on mRNA expression simultaneously. Bioinformatics analysis of the co-expression networks of mRNAs and lncRNAs altered after TBI showed that a majority of them are associated with inflammatory and immunological activity, metabolism, neuronal and vascular networks and cellular function (Zhong et al, 2016) (Fig. 1).…”

Section: Other Non-coding Rnas Altered Following Acute Cns Injuriesmentioning

confidence: 99%

Non-coding RNAs and neuroprotection after acute CNS injuries

Chandran

Mehta

2017

Neurochemistry International

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Accumulating evidence indicates that various classes of non-coding RNAs (ncRNAs) including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and long non-coding RNAs (lncRNAs) play important roles in normal state as well as the diseases of the CNS. Interestingly, ncRNAs have been shown to interact with messenger RNA, DNA and proteins, and these interactions could induce epigenetic modifications and control transcription and translation, thereby adding a new layer of genomic regulation. The ncRNA expression profiles are known to be altered after acute CNS injuries including stroke, traumatic brain injury and spinal cord injury that are major contributors of morbidity and mortality worldwide. Hence, a better understanding of the functional significance of ncRNAs following CNS injuries could help in developing potential therapeutic strategies to minimize the neuronal damage in those conditions. The potential of ncRNAs in blood and CSF as biomarkers for diagnosis and/or prognosis of acute CNS injuries has also gained importance in the recent years. This review highlighted the current progress in the understanding of the role of ncRNAs in initiation and progression of secondary neuronal damage and their application as biomarkers after acute CNS injuries.

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“…Recently, a series of studies have found that epigenetic changes play important roles in TBI-induced pathophysiological responses such as DNA methylation, chromatin post-translational modifications, and miRNA regulation of gene expression [5,9,10]. Epigenetics refers to the up-or down-regulation of gene or protein expression without changing the DNA sequence [11].…”

Section: Introductionmentioning

confidence: 99%

Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

Zhang

et al. 2020

Mol Brain

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Background: N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification of eukaryotic mRNA. It has been reported that there is a stimulus-dependent regulation of m6A in the mammalian central nervous system in response to sensory experience, learning, and injury. The mRNA m6A methylation pattern in rat cortex after traumatic brain injury (TBI) has not been investigated. Results: In this study, we conducted a genome-wide profiling of mRNA m6A methylation in rat cortex via methylated RNA immunoprecipitation sequencing (MeRIP-Seq). After TBI, the expressions of METTL14 and FTO were significantly down-regulated in rat cerebral cortex. Using MeRIP-Seq, we identified a total of 2165 significantly changed peaks, of which 1062 were significantly up-regulated and 1103 peaks were significantly down-regulated. These m6A peaks were located across 1850 genes. The analysis of both m6A peaks and mRNA expression revealed that there were 175 mRNA significantly altered methylation and expression levels after TBI. Moreover, it was found that functional FTO is necessary to repair neurological damage caused by TBI but has no effect on the spatial learning and memory abilities of TBI rats by using FTO inhibitor FB23-2.Conclusion: This study explored the m6A methylation pattern of mRNA after TBI in rat cortex and identified FTO as possible intervention targets in the epigenetic modification of TBI.

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Altered expression of long non-coding RNA and mRNA in mouse cortex after traumatic brain injury

Cited by 67 publications

References 53 publications

Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Invited Review: Long non‐coding RNAs: important regulators in the development, function and disorders of the central nervous system

Non-coding RNAs and neuroprotection after acute CNS injuries

Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury

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