Altered Expression of CD300a Inhibitory Receptor on CD4+ T Cells From Human Immunodeficiency Virus-1-Infected Patients: Association With Disease Progression Markers

Vitallé, Joana; Terrén, Íñigo; Gamboa-Urquijo, Leire; Orrantia, Ane; Tarancón-Díez, Laura; Genebat, Miguel; Ruiz‐Mateos, Ezequiel; Leal, Manuel; García-Obregón, Susana; Zenarruzabeitia, Olatz; Borrego, Francisco

doi:10.3389/fimmu.2018.01709

Cited by 11 publications

(19 citation statements)

References 57 publications

(87 reference statements)

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“…In both, B cells and CD4+ T lymphocytes, cART did not revert the altered CD300a expression in HIV-1 + patients 24,38 . However, a CD4+ T cell subset co-expressing CD300a, PD1 and CD38 was expanded in naïve HIV-1+ individuals, which was found in very low numbers in HIV negative donors and in patients under cART 38 . Interestingly, a negative correlation between CD300a expression on CD4+ T lymphocytes and markers associated with HIV-1 disease progression was discovered 38 .…”

mentioning

confidence: 80%

“…In contrast, an altered CD300a expression pattern in the lymphoid lineage has been described. HIV-1+ individuals exhibited a lower expression of CD300a on B cells 24 , while they displayed higher CD300a levels on CD4+ T cells 38 , when compared with HIV negative donors. In both, B cells and CD4+ T lymphocytes, cART did not revert the altered CD300a expression in HIV-1 + patients 24,38 .…”

mentioning

confidence: 91%

“…HIV-1+ individuals exhibited a lower expression of CD300a on B cells 24 , while they displayed higher CD300a levels on CD4+ T cells 38 , when compared with HIV negative donors. In both, B cells and CD4+ T lymphocytes, cART did not revert the altered CD300a expression in HIV-1 + patients 24,38 . However, a CD4+ T cell subset co-expressing CD300a, PD1 and CD38 was expanded in naïve HIV-1+ individuals, which was found in very low numbers in HIV negative donors and in patients under cART 38 .…”

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confidence: 91%

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Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Vitallé

Terrén

Gamboa-Urquijo

et al. 2020

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CD300a receptor is found on different CD8+ T cell subsets and its expression has been associated to a more cytotoxic molecular signature. CD300a has an important role in some viral infections and its expression levels are known to be modulated by human immunodeficiency virus (HIV)−1 infection on several cell types. The main objective of this work was to investigate CD300a expression and its regulation during HIV-1 specific CD8+ T cell responses. CD300a receptor expression was analysed by multiparametric flow cytometry on CD8+ T lymphocytes from HIV negative donors, naive HIV-1+ individuals and HIV-1+ subjects under suppressive combined antiretroviral therapy (cART). HIV-1 specific CD8+ T cell response was studied by stimulating cells with HIV-1 derived peptides or with a GagHIV-1 peptide. Our results showed that HIV-1 specific CD8+ T cells expressing higher levels of CD300a were more polyfunctional showing an increased degranulation and cytokine production. Moreover, we observed an up-regulation of CD300a expression after Gag HIV-1 peptide stimulation. Finally, our results demonstrated an inverse correlation between CD300a expression on CD8+ T lymphocytes and HIV disease progression markers. In conclusion, CD300a expression is associated to a better and more polyfunctional HIV-1 specific CD8+ T cell response. CD8+ T cells are very important effectors in the control and clearance of viruses through several mechanisms, including granule exocytosis and cytokine production 1-3 . Many reports have shown that CD8+ T cells play a very important role in the control of viral replication during the acute phase of human immunodeficiency virus (HIV)−1 infection, contributing to the initial control of infection 1,3-7 . Thus, a large number of current studies are focused on the search of new therapies with the aim of inducing a potent and effective HIV specific CD8+ T cell response [8][9][10] .After antigen recognition and subsequent activation, CD8+ T cells up-regulate the expression of inhibitory receptors with the aim of preventing an excessive response that, if not properly regulated, could be harmful to the host 11,12 . During chronic stimulation, as for example persistent exposure to HIV antigens, CD8+ T cells became progressively dysfunctional and exhausted, and the expression of inhibitory receptors persists 13 . Exhaustion is a process characterized by a loss of proliferative capacity, differentiation and effector functions 12,14,15 . There are several inhibitory receptors that are expressed on exhausted T cells. For instance, programed cell death-1 (PD1) is known to be involved in the regulation of CD8+ T lymphocytes function during chronic HIV-1 infection and their expression correlates with disease progression 11,12,15 . In addition to the negative regulatory role of these inhibitory receptors, they also mark antigen specific T cells. For example, it has been described that PD1 on CD8+ T cells identifies the repertoire of clonally expanded tumor-reactive lymphocytes and situations of chronic inflammation, which is ...

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confidence: 80%

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confidence: 91%

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confidence: 91%

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Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Vitallé

Terrén

Gamboa-Urquijo

et al. 2020

Sci Rep

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“…Interestingly, a CD4 + T‐cell subset coexpressing CD300a, PD1, and CD38 was significantly expanded in HIV infected patients that were not receiving cART, while it was very rare in healthy donors and patients on cART. Furthermore, a correlation between CD300a expression on CD4 + T cells and markers associated with disease progression was found . Other members of the CD300 family have been studied during HIV infection.…”

Section: Cd300 Molecules and Cellular Responses To Viral Infectionsmentioning

confidence: 98%

“…The altered expression of CD300a is not corrected by effective combined anti‐retroviral therapy (cART), suggesting that residual effects of HIV infection are sufficient to maintain low levels of CD300a on B cells . Within CD4 + T cells, CD300a is differentially expressed among different cell subsets , and its cell surface levels are also altered during HIV infection, independently of the introduction of cART . Interestingly, a CD4 + T‐cell subset coexpressing CD300a, PD1, and CD38 was significantly expanded in HIV infected patients that were not receiving cART, while it was very rare in healthy donors and patients on cART.…”

Section: Cd300 Molecules and Cellular Responses To Viral Infectionsmentioning

confidence: 99%

CD300 receptor family in viral infections

et al. 2018

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The CD300 molecules constitute an evolutionarily significant family of receptors that are expressed on myeloid and lymphoid cells, but also on other cell types, such as tuft cells. Many of the CD300 receptors have been shown to recognize lipids, e.g. phosphatidylserine and phosphatidylethanolamine. Over the past couple of years, accumulating evidence has shown that this family of receptors is involved in the pathogenesis of many diseases. Specifically, CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells. The participation of CD300 molecules in viral infection includes both lipid dependent and independent mechanisms, as for example in infections with dengue virus (DENV) and murine norovirus (MNV), respectively. CD300 receptors are also involved in viral escape mechanisms, for instance inhibiting NK cell‐mediated cytotoxicity against infected cells. Moreover, it is becoming increasingly recognized that the expression of CD300 receptors is altered during viral diseases. Here, we review the involvement of human and murine CD300 molecules in viral binding and entry and in cellular responses to viruses, which highlights the potential of CD300 molecules in the search of new biomarkers for various stages of infection and therapeutic targets for the treatment of viral infections.

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Leishmania donovani induces CD300a expression to dampen effector properties of CD11c+ dendritic and antigen activated CD8+ T cells

et al. 2023

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Altered Expression of CD300a Inhibitory Receptor on CD4+ T Cells From Human Immunodeficiency Virus-1-Infected Patients: Association With Disease Progression Markers

Cited by 11 publications

References 57 publications

Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

CD300 receptor family in viral infections

Leishmania donovani induces CD300a expression to dampen effector properties of CD11c+ dendritic and antigen activated CD8+ T cells

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