Altered dental root development in long-term survivors of pediatric acute lymphoblastic leukemia. A review of 17 cases

Rosenberg, Simon W.; Kolodney, Harold; Wong, George Y.; Murphy, Michael

doi:10.1002/1097-0142(19870501)59:9<1640::aid-cncr2820590920>3.0.co;2-v

Cited by 84 publications

(46 citation statements)

References 30 publications

(5 reference statements)

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“…[6][7][8][9][10][11] In our reported cases, even the short course of chemotherapy necessary for myeloablation before bone marrow transplantation in the treatment of severe combined immunodeficiency resulted in the development of the severe dental anomalies shown in Figures 1, 2 and 3.…”

Section: Discussionmentioning

confidence: 61%

“…While most of these findings have previously been reported in long-term survivors of childhood cancers who received chemotherapy for a much longer term [6][7][8][9][10][11] and in children who received BMT after total body irradiation, 12 no previous findings have been documented in children receiving short-term chemotherapy without irradiation followed by BMT in the management of SCID.…”

Section: Discussionmentioning

confidence: 95%

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Dental manifestations in severe combined immunodeficiency following bone marrow transplantation

Welbury

Bond

Abinun

2000

Bone Marrow Transplant

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Summary:Severe combined immunodeficiency (SCID) is a rare primary immunodeficiency disorder with an estimated overall frequency of 1 in 75 000 live births. Bone marrow transplantation is the only curative treatment available. Using T cell-depleted HLA non-identical bone marrow requires preconditioning with a short course of cytotoxic chemotherapy. We report severe dental developmental anomalies in three such patients under longterm follow up. Bone Marrow Transplantation (2000) 25, 1007-1009. Keywords: SCID; BMT; dental developmental anomalies Severe combined immunodeficiency (SCID) is a rare primary immunodeficiency with an overall frequency estimated to be 1 in 75 000 live births. 1 SCID represents a group of diseases characterised by deficient T and B cell function with resulting susceptibility to infection and secondary failure of the patients to thrive. SCID syndromes are caused by multiple genetic defects and are fatal usually within the first year of life. Bone marrow transplantation (BMT) is the only curative treatment available. 2 BMT was introduced in the treatment of primary immunodeficiencies about 30 years ago. Since then BMT has made it possible to cure a substantial number of children who would otherwise not have survived. 2,3 In Europe, the overall 2-year survival for BMT for SCID is now over 60%. 3 At present, there are only two specialised centres in the United Kingdom for treating children with severe combined immunodeficiency. Both units, Great Ormond Street Hospital for Sick Children and Newcastle General Hospital are each transplanting about 15-20 children per year. Longterm follow-up post BMT of these children shows that the majority (85%) have normal life of good quality, normal growth and development and good overall immune function. 4 Survival however is not without costs as cytotoxic treatment does not discriminate between myeloid and Correspondence: BOI Cole,

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 95%

Dental manifestations in severe combined immunodeficiency following bone marrow transplantation

Welbury

Bond

Abinun

2000

Bone Marrow Transplant

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“…This indicates that HERS cells are sensitive to vinblastine at/near commonly used pharmacologic doses, and adds support to clinical findings that abnormal root morphology in childhood cancer survivors is the result of damage to HERS cells proliferating at the time of chemotherapy. [1][2][3][4][5][6][7] There was a beneficial effect of photobiomodulation on HERS cell recovery from vinblastine exposure. The greatest effects of the light treatment were noted at the LD 50 .…”

Section: Discussionmentioning

confidence: 99%

“…1 Numerous studies of the long-term effects of chemotherapy on dental development have found that the most common abnormality is atypical root morphology. [2][3][4][5][6][7] Hertwig's epithelial root sheath (HERS) cells are considered to be the cells responsible for root formation. The apical migration of these cells during root development determines the eventual morphology of the root.…”

Section: Introductionmentioning

confidence: 99%

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells

Hodgson

Pyszka

Henry

et al. 2011

Photomedicine and Laser Surgery

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Objective: The aim of this study was to investigate the effect of near-infrared (NIR) photobiomodulation on the proliferation and glutathione levels in murine Hertwig's epithelial root sheath (HERS) cells after poisoning with vinblastine. Background: Photobiomodulation has been shown to improve wound healing in a number of animal models. There have been no studies on the effect of photobiomodulation on cancer-related chemotherapy injury to the cells that initiate tooth root growth. Materials and Methods: Control groups consisted of murine HERS cells without vinblastine (VBÀ) and cells with vinblastine at 10, 20, and 30 ng/mL (VB10, VB20, and VB30). Experimental groups consisted of these same groups with light therapy (VB-L, VB10L, VB20L, and VB30L). The cells were exposed to vinblastine for 1 h.

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“…Depuis cette date, une série de publications majoritairement descriptives et rétrospectives, ont renforcé cette hypothèse : Rosenberg et coll. [9] , Maguire et coll. [10] , Purdell-Lewis et coll.…”

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Chimiothérapie anticancéreuse et développement dentaire

Nawrocki¹,

Libersa²,

Porée

et al. 2003

Med Buccale Chir Buccale

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RÉSUMÉLes progrès du traitement des cancers de l'enfant posent le problème des séquelles dues aux thérapeu-tiques appliquées pendant l'odontogenèse. Si les effets iatrogènes des radiations ionisantes sont bien analysés, les répercussions des seuls antimitotiques sur la dentition sont moins connues. C'est pourquoi, afin d'éviter les biais liés à des observations rétrospectives, 13 enfants souffrant en majorité d'une leucémie aiguë lymphoblastique et tous traités par le même protocole chimiothérapique ont été suivis prospectivement ainsi que 11 enfants témoins. L'influence des antimitotiques sur la dentition est abordée sous deux angles : la mesure de la croissance de la deuxième molaire mandibulaire droite, dent choisie en référence, pendant les différentes phases du protocole chimiothérapique puis en rémission et la surveillance de l'apparition d'anomalies dentaires. Le support est l'utilisation d'orthopantomogrammes tirés à intervalles régu-liers après étude du grandissement induit par le générateur. Les résultats convergent vers un ralentissement de la vitesse de minéralisation coronaire de la 47 par la chimiothérapie d'induction-consolidation alors que le rythme radiculaire semble insensible à toutes les phases de chimiothérapie. La non prise en compte possible pour le moment d'éventuels défauts structurels amélo-dentinaires sousestime certainement l'importance des troubles. Cependant déjà, 8 enfants sur 13 ont développé des anomalies dentaires corrélées à la période d'administration des antimitotiques. Les troubles les plus récurrents sont des racines dentaires grêles et/ou courtes (5 enfants) et les agénésies (3 enfants). Quelque soit l'anomalie, la dent la plus fréquemment touchée est la seconde prémolaire. Les atteintes les plus importantes (agénésies, microdonties) concernent les enfants traités les plus jeunes. SUMMARY Since the incidence of chemotherapy on developing dentition is poorly documented, 13 children affected by an acute lymphoblastic leukemia and treated by polychemotherapy were assessed versus 11 controls. Measurements of tooth growth as well as dental abnormalities were evaluated. Control X-rays have also been performed before and after unduction-consolidation and 6 months after remission. Significant differences regarding the rythms of the crown mineralization between periods with and without induction-consolidation chemotherapy were found. 8 of 13 children showed altered roots (5 children) and hypodontia (8 children) correlated with the anti-leukemia treatment.The second premolar was the most affected tooth. Furthermore, the effects were more important when the chemotherapy was administrated before the age of 5. However, histological studies are required in order to investigate the effect of chemotherapy on dental structures such as enamel.

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Altered dental root development in long-term survivors of pediatric acute lymphoblastic leukemia. A review of 17 cases

Cited by 84 publications

References 30 publications

Dental manifestations in severe combined immunodeficiency following bone marrow transplantation

Dental manifestations in severe combined immunodeficiency following bone marrow transplantation

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells

Chimiothérapie anticancéreuse et développement dentaire

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