Altered Brain Activity in Patients with Diabetic Retinopathy Using Regional Homogeneity: a Resting-State fmri Study

Liao, Xu‐Lin; Yuan, Qing; Shi, Wen‐Qing; Li, Biao; Su, Ting; Lin, Qian; Min, You‐Lan; Zhu, Pei‐Wen; Ye, Lei; Shao, Yi

doi:10.4158/ep-2018-0517

Cited by 21 publications

(27 citation statements)

References 36 publications

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“…A total of 47 articles were identified through the systematic literature search, and Figure 1 shows the details of study selection process. We finally included 16 studies (19 T2DM datasets and 15 healthy controls datasets) in the final meta-analysis (Xia et al, 2013;Cui et al, 2014;Wang et al, 2014Wang et al, , 2019Zhou et al, 2014;Liu et al, 2016;Peng et al, 2016;Wang Y. F. et al, 2017;Wang Z. L. et al, 2017;Liao et al, 2019;Liu Y. et al, 2020;Qi et al, 2020;Shi et al, 2020;Xiong et al, 2020;Zhang Y. Q. et al, 2020). In two studies of ReHo, the analysis was performed in two different T2DM subgroups (Peng et al, 2016;Xiong et al, 2020), and in another study, the analysis was performed with ALFF and ReHo (Cui et al, 2014).…”

Section: Included Studies and Sample Characteristicsmentioning

confidence: 99%

“…For example, increased regional activity has been found in the lingual gyrus, middle temporal gyrus, and precuneus (Wang et al, 2014;Zhou et al, 2014;Wang Z. L. et al, 2017;Liu Y. et al, 2020), whereas decreased activity in these regions has also been reported (Xia et al, 2013;Cui et al, 2014;Wang Y. F. et al, 2017), and yet more studies have identified no changes (Liu et al, 2016;Liao et al, 2019;. This inconsistency resulted in part from small samples and from studying patients with various comorbidities, such as microangiopathy, including retinopathy, nephropathy, and peripheral neuropathy (Xia et al, 2013;Cui et al, 2014;Wang Z. L. et al, 2017;Liao et al, 2019;Qi et al, 2020); vitreous hemorrhage (Shi et al, 2020;Zhang Y. Q. et al, 2020); mild cognitive impairment (Zhou et al, 2014;Xiong et al, 2020); cirrhosis (Wang Y. F. et al, 2017); hypertension (Cui et al, 2014;Zhou et al, 2014); and dyslipidemia (Wang et al, 2014), which were known to alter brain function (Weissenborn et al, 2004;Umegaki et al, 2012;Umemura et al, 2013;Friedman et al, 2014;Muela et al, 2017). Thus, the central question of how the brain regional function manifests remains unaddressed in T2DM.…”

Section: Introductionmentioning

confidence: 99%

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Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies

Liu

Yang

et al. 2021

Front. Aging Neurosci.

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Objective: Resting-state functional magnetic resonance imaging (rs-fMRI) studies have revealed inconsistent regional spontaneous neural activity alterations in patients with type 2 diabetes mellitus (T2DM). The aim of our meta-analysis was to identify concordant regional spontaneous neural activity abnormalities in patients with T2DM.Methods: A systematic search was conducted to identify voxel-based rs-fMRI studies comparing T2DM patients with healthy controls. The permutation of subject images seed-based d mapping (SDM) was used to quantitatively estimate the regional spontaneous neural activity abnormalities in patients with T2DM. Metaregression was conducted to examine the associations between clinical characteristics and functional alterations.Results: A total of 16 studies with 19 datasets including 434 patients with T2DM and 391 healthy controls were included. Patients with T2DM showed hypoactivity in the right medial superior frontal gyrus, right superior temporal gyrus, and left lingual gyrus, whereas hyperactivity in the right cerebellum. Metaregression analysis identified negative correlation between regional activity in the medial superior frontal and anterior cingulate gyri and illness duration of patients with T2DM.Conclusion: The patterns of regional spontaneous neural activity alterations, characterized by hypoactivity in the medial pre-frontal cortex, visual cortex, and superior temporal gyrus, whereas hyperactivity in the cerebellum, might represent the underlying neuropathological mechanisms of T2DM.

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Section: Included Studies and Sample Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies

Liu

Yang

et al. 2021

Front. Aging Neurosci.

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“… Author Year Disease Refs. Ophthalmological diseases Song et al 2014 Glaucoma 26 Cui et al 2014 Diabetic retinopathy 27 Shao et al 2015 Optic neuritis 28 Xu et al 2019 Corneal ulcer 29 Xiang et al 2019 Trigeminal neuralgia 30 Liao et al 2019 Diabetic retinopathy 31 Neurogenic diseases Dai et al 2012 Sleep disorders 32 Li et al 2016 Parkinson's disease 33 …”

Section: Discussionmentioning

confidence: 99%

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Kang

Guo

et al. 2021

Sci Rep

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This study investigated neurologic changes in patients with dry eye (DE) by functional magnetic resonance imaging (fMRI) and to used regional homogeneity (ReHo) analysis to clarify the relationship between these changes and clinical features of DE. A total of 28 patients with DE and 28 matched healthy control (HC) subjects (10 males and 18 females in each group) were enrolled. fMRI scans were performed in both groups. We carried out ReHo analysis to assess differences in neural activity between the 2 groups, and receiver operating characteristic curve (ROC) analysis was performed to evaluate the performance of ReHo values of specific brain areas in distinguishing DE patients from HCs. The relationship between average ReHo values and clinical characteristics was assessed by correlation analysis. ReHo values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in DE patients compared to HCs. The ROC analysis showed that ReHo value had high accuracy in distinguishing between DE patients and HCs (P < 0.0001). The ReHo values of the middle frontal gyrus and dorsolateral superior frontal gyrus were correlated to disease duration (P < 0.05). Symptoms of ocular surface injury in DE patients are associated with dysfunction in specific brain regions, which may underlie the cognitive impairment, psychiatric symptoms, and depressive mood observed in DE patients. The decreased ReHo values of some brain gyri in this study may provide a reference for clinical diagnosis and determination of treatment efficacy.

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“…33 However, in another study, patients with diabetic retinopathy had markedly lower ReHo values in the right anterior cingulate gyrus, right cuneus, bilateral anterior, and left middle frontal gyrus. 34 In this study, patients with CU showed increased FC values in the right cingulate gyrus. However, the mechanism involved in this process remains to be explored.…”

Section: Analysis Of Increased Fc Values In the Cu Groupmentioning

confidence: 47%

“…35 Liao XL el et have reported that the right cuneus ReHo value of patients with diabetic retinopathy was significantly reduced. 34 Studies showed that the wedge FC of female patients with glaucoma was reduced compared with that observed in healthy subjects. 36 Moreover, the application of amplitude of low-frequency fluctuations for rs-fMRI revealed that the value of the bilateral cuneus in patients with primary open-angle glaucoma was decreased, and the spontaneous activity of the left cuneus was negatively correlated with the severity of the disease.…”

Section: Analysis Of Lower Fc Values In the Cu Groupmentioning

confidence: 99%

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

Tang

Fang

et al. 2020

NDT

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To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using restingstate functional magnetic resonance imaging. Patients and Methods: A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample t-test, receiver operating characteristic curve, and Pearson's correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients. Results: The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions. Conclusion: CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.

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Altered Brain Activity in Patients with Diabetic Retinopathy Using Regional Homogeneity: a Resting-State fmri Study

Cited by 21 publications

References 36 publications

Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies

Regional Spontaneous Neural Activity Alterations in Type 2 Diabetes Mellitus: A Meta-Analysis of Resting-State Functional MRI Studies

Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

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