Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Kang, Yu; Guo, Yu; Ge, Qian‐Min; Su, Ting; Shi, Wen‐Qing; Zhang, Lijuan; Shu, Hui‐Ye; Pan, Yi‐Cong; Liang, Rong‐Bin; Li, Qiuyu; Shao, Yi

doi:10.1038/s41598-021-92199-8

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Our previous studies [ 13 – 15 ] found that some ophthalmic diseases can cause brain regional changes. Using fMRI, researchers found that DE may lead to dysfunction of specific brain regions [ 16 ]. Similarly, studies have suggested that abnormal regional homogeneity of the limb-cortical circuit in patients with DE, and this dysfunction may be related to the pathological mechanism of DE [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Altered regional brain white matter in dry eye patients: a brain imaging study

Luo

Liang

et al. 2022

Aging

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This study aimed to investigate the regional changes of brain white matter (WM) in DE patients using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). A total of 25 dry eye patients (PAT) and 25 healthy controls (HC) were recruited. All subjects underwent DTI and NODDI, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), isotropic volume fraction (FISO), intra-cellular volume fraction (FICVF), and orientation dispersion index (ODI) were obtained respectively. Then complete Hospital Anxiety and Depression Scale (HADS), anxiety score (AS) or depression scores (DS) were obtained. Receiver operating characteristic (ROC) curve analysis was used to evaluate the reliability of DTI and NODDI in distinguishing the two groups. DTI revealed that PAT had lower FA in both the left superior longitudinal fasciculus (LSLF) and the corpus callosum (CC), and higher MD in the LSLF, the right posterior limb of the internal capsule and the right posterior thalamic radiation. PAT had significant AD changes in regions including the genu of the CC, the right posterior limb of internal capsule, and the right splenium of the CC. From NODDI, PAT showed increased ODI in the LSLF and increased FISO in the right splenium of the CC. FICVF showed a significant decrease in the LSLF while increased in the left anterior corona radiata and the CC. Furthermore, the average values of MD and FICVF were significantly correlated with DS and AS. Hence the results of this study suggest that there are regional changes in WM in DE patients which may contribute to further understanding of the pathological mechanism of DE.

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Section: Introductionmentioning

confidence: 99%

Altered regional brain white matter in dry eye patients: a brain imaging study

Luo

Liang

et al. 2022

Aging

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“…As reported previously, mental status and meibomian gland function have close relation [21][22][23][24], which could explain the correlation between HADS and meibomian gland area. Third, Yu et al [25] found that regional homogeneity values of some special brain regions, such as the middle frontal gyrus, were signi cantly lower in MGD patients than in healthy controls. These abnormalities can result in depression[26].…”

Section: Discussionmentioning

confidence: 98%

The association of dry eye disease signs and symptoms with anxiety and depression: An observational study

Wang,

Jiang,

et al. 2024

Preprint

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Purpose This study aimed to determine the relationship between dry eye-related symptoms and signs with anxiety and depression. Methods In this observational study, we recruited 63 volunteers, including 51 patients with dry eye disease (DED) and 12 healthy volunteers. Infrared images of the meibomian gland and corneal nerve layer analysis of all patients were assessed. Additionally, the patients completed Hospital Anxiety and Depression Scale (HADS) questionnaire, Ocular Surface Disease Index (OSDI), and dry eye symptom questionnaire. Results HADS-anxiety and HADS-depression scores in the DED group were significantly higher than those in the control group (t = 5.846, P \(<\) 0.001, and t = 4.006, P \(<\) 0.001, respectively). HADS-anxiety and HADS-depression was significantly correlated with DED symptoms (P < 0.05). There was a significant positive correlation between the OSDI and HADS (P < 0.001). There was a significant correlation between HADS-anxiety and mebomian gland area (r = -0.426, P < 0.001) and corneal nerve density (r = -0.345, P < 0.001); HADS-depression was found to be correlated with mebomian gland area (r = -0.517, P < 0.001) and corneal nerve density (r = -0.242, P = 0.016). The predictive equation for HADS-anxiety is as follows: HADS-anxiety = 0.09989*OSDI + -0.00013*CND + -22.54*MGA + 7.128 (P < 0.0001). The predictive equation for HADS-depression is as follows: HADS-depression = 0.06743*OSDI + -18.01*MGA + 5.019 (P < 0.0001). Conclusion Anxiety and depression were significantly correlated with OSDI, CND and MGA in patients with DED. Furthermore, OSDI, CND and MGA have a relatively value for HADS-anxiety and HADS-depression.

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“…Some studies declared that hyperosmolarity could cause ocular surface inflammation and/or nerve damage, which may increase symptoms by peripheral sensitization. With functional magnetic resonance imaging (fMRI), Yu et al 13 found regional homogeneity (ReHo) values of the middle frontal gyrus, inferior frontal gyrus, and superior frontal gyrus were significantly lower in dry eye patients compared to healthy controls. Symptoms of ocular surface injury in DED, especially MGD patients are associated with dysfunction in specific brain regions.…”

Section: Discussionmentioning

confidence: 99%

A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms

Wei

Liang

Cao

et al. 2022

Sci Rep

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Increased prevalence of depression has been found in patients with meibomian gland dysfunction (MGD); however, specific conditions of patients suffered from MGD and depression remains unclear. Our aim was to investigate the prevalence of depression in patients with MGD and analyze the risk factors of depression in MGD patients. In this multi-center cross-sectional study, we enrolled 830 MGD patients and 114 normal controls. Demographic information was collected by designed questionnaires about lifestyle habits, systemic and ocular medical history. Ophthalmic examinations were performed in a formal order. Depression symptoms were evaluated with a questionnaire survey using a modified self-rating depression scale (M-SDS). The correlations between the M-SDS score and demographic and clinical information were analyzed. The prevalence of hyperlipidemia and obstructive sleep apnea–hypopnea syndrome (OSAHS) was higher in the MGD group. There were 78 cases (9.4%) with depressive symptoms in the MGD group whereas there were 4 cases (3.5%) in controls. Similarly, M-SDS was higher in the MGD group. The characteristics of depression in the MGD group included: crying spells, sleep disturbance and depressed appetite. Some systemic diseases (OSAHS, allergy, skin disease) and the use of contact lenses was correlated with an increased risk of depressive symptoms in MGD patients.

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Altered spontaneous activity in the frontal gyrus in dry eye: a resting-state functional MRI study

Cited by 7 publications

References 41 publications

Altered regional brain white matter in dry eye patients: a brain imaging study

Altered regional brain white matter in dry eye patients: a brain imaging study

The association of dry eye disease signs and symptoms with anxiety and depression: An observational study

A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms

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