Altered brain activity and childhood trauma in Chinese adolescents with borderline personality disorder

Xiao, Qian; Yi, Xiaoping; Fu, Yan; Jiang, Furong; Zhang, Zhejia; Huang, Qinlin; Han, Zaide; Chen, Bihong T.

doi:10.1016/j.jad.2022.12.003

Cited by 10 publications

(10 citation statements)

References 51 publications

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“…Spatial preprocessing of rs‐fMRI images was performed with Statistical Parametric Mapping (SPM 12, https://www.fil.ion.ucl.ac.uk/spm/software/spm12/). 25,31 The rs‐fMRI images were corrected in order to reduce acquisition delay and head movement. The subjects whose head movement surpassed 3 mm or rotation surpassed 3° at any moment of rs‐fMRI scanning were eliminated from further analysis.…”

Section: Methodsmentioning

confidence: 99%

“…FC analysis was performed using a region of interest (ROI) approach 31 . From the ALFF analysis, the brain regions with altered activity were used as seeds to analyse their FC to the whole brain.…”

Section: Methodsmentioning

confidence: 99%

“…FC analysis was performed using a region of interest (ROI) approach. 31 From the ALFF analysis, the brain regions with altered activity were used as seeds to analyse their FC to the whole brain. This approach was used for further investigation of potential FC alterations that could be associated with cognitive function.…”

Section: Fc Analysismentioning

confidence: 99%

“…uk/ spm/ softw are/ spm12/ ). 25,31 The rs-fMRI images were corrected in order to reduce acquisition delay and head movement. The subjects whose head movement surpassed 3 mm or rotation surpassed 3° at any moment of rs-fMRI scanning were eliminated from further analysis.…”

Section: Rs-fmri Data Acquisition and Preprocessingmentioning

confidence: 99%

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Altered brain activity and cognitive impairment in patients with psoriasis

Yi,

Wang,

et al. 2023

Acad Dermatol Venereol

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BackgroundPatients with psoriasis may have cognitive impairment. However, there is limited information regarding intrinsic brain activity and cognitive function in patients with psoriasis.ObjectivesThis study aim to assess alterations of intrinsic brain activity and its association with cognitive function in patients with psoriasis.MethodsA total of 222 patients with psoriasis aged 18–70 years and 144 age and gender‐matched healthy controls (HCs) were enrolled into this study. All subjects underwent brain resting‐state functional magnetic resonance imaging (rs‐fMRI) and neuropsychological testing. The rs‐fMRI data were analysed for both intrinsic brain activity as indicated by amplitude of low‐frequency fluctuation (ALFF) and seed‐based functional connectivity (FC). Correlative analysis of brain activity with cognitive assessment was performed.ResultsCompared with the HCs, patients with psoriasis had worse cognitive performance in the Trail Making Test, Digit Span Test and Stroop Color‐Word Test (p < 0.05). Patients with psoriasis showed decreased ALFF in the left superior frontal gyrus, the left medial superior frontal gyrus and the right precuneus gyrus; as well as enhanced ALFF in the left paracentral lobule (pFWE < 0.05). Significant correlations were noted between the altered ALFF in the four brain regions and cognitive assessment (p < 0.05). Moreover, patients with psoriasis had increased FC between the four brain regions with altered ALFF (seeds) and the left prefrontal gyrus, the left anterior cingulate gyrus, left superior parietal lobule and default mode network (DMN) regions such as the right precuneus gyrus, left inferior parietal lobule, right angular gyrus and bilateral inferior temporal gyrus (pFWE < 0.05).ConclusionsPatients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN–prefrontal circuit. These brain changes may be the underlying neural correlates for cognitive functioning in patients with psoriasis.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Fc Analysismentioning

confidence: 99%

Section: Rs-fmri Data Acquisition and Preprocessingmentioning

confidence: 99%

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Altered brain activity and cognitive impairment in patients with psoriasis

Yi,

Wang,

et al. 2023

Acad Dermatol Venereol

Self Cite

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“…Resting-state functional magnetic resonance imaging (fMRI) studies have found that impulsivity and emotion dysregulation in BPD were associated with functional abnormalities in the frontal cortex and precuneus [ 6 , 7 ], anterior cingulate cortex [ 8 ], and insula [ 9 ]. Task-related brain imaging studies have also found that impulsivity and emotion dysregulation in BPD were associated with dysfunction in the prefrontal cortex [ 10 , 11 ], anterior cingulate cortex [ 12 ], parietal lobes [ 13 ], amygdala and hippocampus [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Altered intrinsic functional network connectivity is associated with impulsivity and emotion dysregulation in drug-naïve young patients with borderline personality disorder

Cao

Liu

Zhong

et al. 2023

bord personal disord emot dysregul

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Background Despite impulse control and emotion regulation being altered in borderline personality disorder (BPD), the specific mechanism of these clinical features remains unclear. This study investigated the functional connectivity (FC) abnormalities within- and between- default mode network (DMN), salience network (SN), and central executive network (CEN) in BPD, and examined the association between aberrant FC and clinical features. We aimed to explore whether the abnormal large-scale networks underlie the pathophysiology of impulsivity and emotion dysregulation in BPD. Methods Forty-one young, drug-naïve patients with BPD (24.98 ± 3.12 years, 20 males) and 42 healthy controls (HCs; 24.74 ± 1.29 years, 17 males) were included in resting-state functional magnetic resonance imaging analyses. Independent component analysis was performed to extract subnetworks of the DMN, CEN, and SN. Additionally, partial correlation was performed to explore the association between brain imaging variables and clinical features in BPD. Results Compared with HCs, BPD showed significant decreased intra-network FC of right medial prefrontal cortex in the anterior DMN and of right angular gyrus in the right CEN. Intra-network FC of right angular gyrus in the anterior DMN was significantly negatively correlated with attention impulsivity in BPD. The patients also showed decreased inter-network FC between the posterior DMN and left CEN, which was significantly negatively correlated with emotion dysregulation. Conclusion These findings suggest that impaired intra-network FC may underlie the neurophysiological mechanism of impulsivity, and abnormal inter-network FC may elucidate the neurophysiological mechanism of emotion dysregulation in BPD.

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Altered gray matter volume and functional connectivity in adolescent borderline personality disorder with non-suicidal self-injury behavior

Ding

et al. 2023

Eur Child Adolesc Psychiatry

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Altered brain activity and childhood trauma in Chinese adolescents with borderline personality disorder

Cited by 10 publications

References 51 publications

Altered brain activity and cognitive impairment in patients with psoriasis

Altered brain activity and cognitive impairment in patients with psoriasis

Altered intrinsic functional network connectivity is associated with impulsivity and emotion dysregulation in drug-naïve young patients with borderline personality disorder

Altered gray matter volume and functional connectivity in adolescent borderline personality disorder with non-suicidal self-injury behavior

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