Altered brain activity and cognitive impairment in patients with psoriasis

Abstract

BackgroundPatients with psoriasis may have cognitive impairment. However, there is limited information regarding intrinsic brain activity and cognitive function in patients with psoriasis.ObjectivesThis study aim to assess alterations of intrinsic brain activity and its association with cognitive function in patients with psoriasis.MethodsA total of 222 patients with psoriasis aged 18–70 years and 144 age and gender‐matched healthy controls (HCs) were enrolled into this study. All subjects underwent brain resting‐state functional magnetic resonance imaging (rs‐fMRI) and neuropsychological testing. The rs‐fMRI data were analysed for both intrinsic brain activity as indicated by amplitude of low‐frequency fluctuation (ALFF) and seed‐based functional connectivity (FC). Correlative analysis of brain activity with cognitive assessment was performed.ResultsCompared with the HCs, patients with psoriasis had worse cognitive performance in the Trail Making Test, Digit Span Test and Stroop Color‐Word Test (p < 0.05). Patients with psoriasis showed decreased ALFF in the left superior frontal gyrus, the left medial superior frontal gyrus and the right precuneus gyrus; as well as enhanced ALFF in the left paracentral lobule (pFWE < 0.05). Significant correlations were noted between the altered ALFF in the four brain regions and cognitive assessment (p < 0.05). Moreover, patients with psoriasis had increased FC between the four brain regions with altered ALFF (seeds) and the left prefrontal gyrus, the left anterior cingulate gyrus, left superior parietal lobule and default mode network (DMN) regions such as the right precuneus gyrus, left inferior parietal lobule, right angular gyrus and bilateral inferior temporal gyrus (pFWE < 0.05).ConclusionsPatients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN–prefrontal circuit. These brain changes may be the underlying neural correlates for cognitive functioning in patients with psoriasis.

Do Atopic Dermatitis and Psoriasis Have an Impact on Cognitive Decline—Latest Research Review

“…Nine studies included in this review are coherent with those findings [30,32,33,[35][36][37][39][40][41]. Yi et al (2024) assessed alterations of intrinsic brain activity and its association with cognitive function in patients with psoriasis. As reported, patients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN-prefrontal circuit.…”

“…As reported, patients with psoriasis had altered brain activity and connectivity in the key brain areas within the DMN-prefrontal circuit. According to the authors, these brain changes may be the underlying neural correlates for cognitive functioning in patients with psoriasis [ 44 ]. The review included a study on the association between the variation in the function of the right and left hemispheres of the brain and the prevalence of atopic dermatitis and psoriasis.…”