Altered Behaviour in Hamsters Conceived and Born in Hypergravity

Sondag, H.N.P.M.; Jong, H.A.A. de; Oosterveld, W. J.

doi:10.1016/s0361-9230(97)00008-7

Cited by 34 publications

(25 citation statements)

References 25 publications

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“…These results complement data on motor dysfunction from other behavioral tests in hypergravity-exposed mammals. Inhibition of motor function by perinatal hypergravity exposure (2.5G) was seen on P28 in swimming and air-righting tests in hamsters (Sondag et al, 1997) and in exploratory tests in juvenile rats exposed to hypergravity (1.8G; Thullier et al, 2002). Motor functions and equilibrium also were significantly inhibited in Wistar-SPF rats flown on board Cosmos biosatellites (Aizikov and Markin, 1981).…”

Section: Discussionmentioning

confidence: 99%

Exposure to altered gravity during specific developmental periods differentially affects growth, development, the cerebellum and motor functions in male and female rats

Nguon

Ladd

Sajdel-Sulkowska

2006

Advances in Space Research

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We previously reported that perinatal exposure to hypergravity affects cerebellar structure and motor coordination in rat neonates. In the present study, we explored the hypothesis that neonatal cerebellar structure and motor coordination may be particularly vulnerable to the effects of hypergravity during specific developmental stages. To test this hypothesis, we compared neurodevelopment, motor behavior and cerebellar structure in rat neonates exposed to 1.65 G on a 24-ft centrifuge during discrete periods of time: the 2 nd week of pregnancy [gestational day (G) 8 through G15; group A], the 3 rd week of pregnancy (G15 through birth on G22/G23; group B), the 1 st week of nursing [birth through postnatal day (P) 6; group C], the 2 nd and 3 rd weeks of nursing (P6 through P21; group D), the combined 2 nd and 3 rd weeks of pregnancy and nursing (G8 through P21; group E) and stationary control (SC) neonates (group F). Prenatal exposure to hypergravity resulted in intrauterine growth retardation as reflected by a decrease in the number of pups in a litter and lower average mass at birth. Exposure to hypergravity immediately after birth impaired the righting response on P3, while the startle response in both males and females was most affected by exposure during the 2 nd and 3 rd weeks after birth. Hypergravity exposure also impaired motor functions, as evidenced by poorer performance on a rotarod; while both males and females exposed to hypergravity during the 2 nd and 3 rd weeks after birth performed poorly on P21, male neonates were most dramatically affected by exposure to hypergravity during the second week of gestation, when the duration of their recorded stay on the rotarod was one half that of SC males. Cerebellar mass was most reduced by later postnatal exposure. Thus, for the developing rat cerebellum, the postnatal period that overlaps the brain growth spurt is the most vulnerable to hypergravity. However, male motor behavior is also affected by midpregnancy exposure to hypergravity, suggesting discrete and sexually dimorphic windows of vulnerability of the developing central nervous system to environmental perturbations.

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Section: Discussionmentioning

confidence: 99%

Exposure to altered gravity during specific developmental periods differentially affects growth, development, the cerebellum and motor functions in male and female rats

Nguon

Ladd

Sajdel-Sulkowska

2006

Advances in Space Research

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“…Nevertheless, permanent deficits induced by early gravity deprivation suggest that development of appropriate relay centers in the brain is stimulusdependent and must occur within a critical period. Similarly, gestational exposure of baby hamsters to hypergravity permanently alters subsequent behaviors that require normal vestibular function (Sondag et al, 1997). This suggests that proper neural development is sensitive to the magnitude, not just the presence or absence, of gravimetric stimulation.…”

Section: Discussionmentioning

confidence: 99%

Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish

2000

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“…Some transient effects were found in pups, suggesting a delayed development, dependant on the vestibular system ), but rats recovered rapidly, especially if they returned to normogravity before P15. Vestibular alteration during the development did not show long term difference in air righting reflex even though a deficit persisted in swimming at youngest ages (Wubbels and de Jong 2000), whereas hamsters showed a significant deficit that prolonged after months (Sondag et al 1997). It is possible that a maturation speed was involved, because hamsters are precocial species and maturate faster than rats.…”

Section: Introductionmentioning

confidence: 91%

Ground-Based Researches on the Effects of Altered Gravity on Mice Development

Jamon

Serradj

2008

Microgravity Sci. Technol.

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This chapter reviews some consequences of the exposure to an altered gravity environment on the development of small mammals. A point is made on the possible existence of several critical periods, and their interactions, in relation with the multiple points of application of the gravity influence on developing organisms, and the need to coordinate the researches on the various structures concerned. The European effort to integrate a multidisciplinary exploration, from the genes expression to the behavioural output, in a topical team is presented, and a new French centrifuge facility for mice is described. A second part reports the preliminary results of a study on the motor performance of ageing (9 months) mice exposed to Hypergravity (2 g), in the new French centrifuge, between the 10th to 31 postnatal day, a key period for motor development in mice. This study shows for the first time that a transient exposure to an hypergravity environment during the period of motor development in the mouse produced an irreversible modification of the motor function.

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Altered Behaviour in Hamsters Conceived and Born in Hypergravity

Cited by 34 publications

References 25 publications

Exposure to altered gravity during specific developmental periods differentially affects growth, development, the cerebellum and motor functions in male and female rats

Exposure to altered gravity during specific developmental periods differentially affects growth, development, the cerebellum and motor functions in male and female rats

Development of utricular otoliths, but not saccular otoliths, is necessary for vestibular function and survival in zebrafish

Ground-Based Researches on the Effects of Altered Gravity on Mice Development

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