Alterations of Vasoactive Intestinal Polypeptide Receptors in Allergic Rhinitis

Kim, Dae Hyung; Park, Il Ho; Cho, Jung Sun; Lee, You Mi; Choi, Hyuk; Lee, Heung Man

doi:10.2500/ajra.2011.25.3568

Cited by 22 publications

(15 citation statements)

References 20 publications

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“…Notably, the enhanced expression of VIP and its receptors (VPAC-1 and VPAC-2) in the nasal mucosa of AR patients were observed suggesting an increased expression level of VIP receptors as one of the possible explanation for nasal hyperresponsiveness in allergic rhinitis patients [116]. Similarly, the significant increase in neuropeptide-containing nerve fibers especially VIPergic fibers were observed emphasized the involvement of innervation in these allergic rhinitis patients [117].…”

Section: Significance Of Vip In the Allergic Diseasesmentioning

confidence: 99%

“…Additionally, conjugated alpha-alumina nanoparticle with VIP has been proposed as an effective nano-drug for the treatment of asthma [150]. Additionally, induced expression of VIP and VIP associated receptors were reported in patients with atopic dermatitis [20, 129], allergic rhinitis [116] and EoE [63], suggesting the use of stable VIP antagonists or specific VIP receptors antagonist may be the logical approach for improving these inflammatory diseases.…”

Section: Therapeutic Approachesmentioning

confidence: 99%

See 1 more Smart Citation

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Verma

Manohar

Venkateshaiah

et al. 2017

Cytokine & Growth Factor Reviews

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Worldwide increase incidences of allergic diseases have heightened the interest of clinicians and researchers to understand the role of neuroendocrine cells in the recruitment and activation of inflammatory cells. Several pieces of evidence revealed the association of neuropeptides in the pathogenesis of allergic diseases. Importantly, one such peptide that is secreted by neuronal cells and immune cells exerts a wide spectrum of immunological functions as cytokine/chemokine is termed as Vasoactive Intestinal Peptide (VIP). VIP mediates immunological function through interaction with specific receptors namely VPAC-1, VPAC-2, CRTH2 and PAC1 that are expressed on several immune cells such as eosinophils, mast cells, neutrophils, and lymphocytes; therefore, provide the basis for the action of VIP on the immune system. Additionally, VIP mediated action varies according to target organ depending upon the presence of specific VIP associated receptor, involved immune cells and the microenvironment of the organ. Herein, we present an integrative review of the current understanding on the role of VIP and associated receptors in allergic diseases, the presence of VIP receptors on various immune cells with particular emphasis on the role of VIP in the pathogenesis of allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis. Being crucial signal molecule of the neuroendocrine-immune network, the development of stable VIP analogue and/or antagonist may provide the future therapeutic drug alternative for the better treatment of these allergic diseases. Taken together, our current review summarizes the current understandings of VIP biology and further explore the significance of neuroendocrine cells derived VIP in the recruitment of inflammatory cells in allergic diseases that may be helpful to the investigators for planning the experiments and accordingly predicting new therapeutic strategies for combating allergic diseases. Summarized graphical abstract will help the readers to understand the significance of VIP in allergic diseases.

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Section: Significance Of Vip In the Allergic Diseasesmentioning

confidence: 99%

Section: Therapeutic Approachesmentioning

confidence: 99%

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Verma

Manohar

Venkateshaiah

et al. 2017

Cytokine & Growth Factor Reviews

View full text Add to dashboard Cite

show abstract

“…VIP, released by parasympathetic reflexes, has important functions in nasal cavity, such as glandular discharge and vasodilatation. Similarly, its receptor has been shown to be increased in the nasal mucosa of allergic rhinitis 37 38 . In the present study, the level of SP was significantly increased in the SPG acupuncture group compared to sham acupuncture group only at 30 minutes after acupuncture, which appears to be consistent with the intensity of pain induced by the direct stimulation of the subset of sensory nerves in SPG.…”

Section: Discussionmentioning

confidence: 98%

Sphenopalatine Ganglion Acupuncture Improves Nasal Ventilation and Modulates Autonomic Nervous Activity in Healthy Volunteers: A Randomized Controlled Study

Wang

Chen

Wang

et al. 2016

Sci Rep

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The study aimed to assess the effects of Sphenopalatine ganglion (SPG) acupuncture on nasal ventilation function and autonomic nervous system in health volunteers. 39 healthy subjects were randomly assigned to either active SPG acupuncture group (AA group) or sham-SPG acupuncture group (SA group). All subjects were assessed for self-reported nasal ventilation, nasal patency (nasal airway resistance (NAR) and nasal cavity volume (NCV), exhaled nasal nitric oxide (nNO), and neuropeptides (substance P(SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY)) in nasal secretions at baseline, 30 minutes, 2 hours, and 24 hours after acupuncture. Significantly more subjects in AA group reported improvements in nasal ventilation at all time points after acupuncture, compared to SA group. NAR and NCV were also significantly lower in AA group than SA group. The level of nNO in AA group was significantly decreased after 24 hours compared to SA group. The level of NPY was significantly increased in AA group at 30 minutes and 2 hours compared to baseline and SA group. The levels of SP and VIP were not significantly different in the two groups. We concluded that SPG acupuncture could help to improve nasal ventilation by increasing sympathetic nerve excitability in healthy volunteers.

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“…The contribution of VIP to allergic rhinitis has also been studied, with high levels of VIP and its receptors found in nasal mucosa of patients with this condition [12,14,15]. Kim et al [15] recently evaluated VIP downstream receptors VPAC1R and VPAF2R via mRNA collection and western blot analysis, revealing that both mRNA and protein levels were significantly increased in nasal mucosa among perennial allergic rhinitis patients compared with control patients undergoing augmentation rhinoplasty.…”

Section: Alternative Pathophysiology Of Allergic Rhinitismentioning

confidence: 99%

Climate change and its impact on allergic rhinitis and other allergic respiratory diseases

Lin

Zacharek

2012

Current Opinion in Otolaryngology & Head and Neck Surgery

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Alterations of Vasoactive Intestinal Polypeptide Receptors in Allergic Rhinitis

Abstract: These results suggest that an increased expression level of VIP receptors is one possible explanation for nasal hyperresponsiveness in patients with allergic rhinitis.

Cited by 22 publications

References 20 publications

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases

Sphenopalatine Ganglion Acupuncture Improves Nasal Ventilation and Modulates Autonomic Nervous Activity in Healthy Volunteers: A Randomized Controlled Study

Climate change and its impact on allergic rhinitis and other allergic respiratory diseases

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