Alterations of the renal function and oxidative stress in renal tissue from rats chronically treated with aluminium during the initial phase of hepatic regeneration

Mahieu, Stella; Millen, Néstor; González, Marcela; Contini, María del Carmen; Elı́as, Marı́a Mónica

doi:10.1016/j.jinorgbio.2005.06.023

Cited by 35 publications

(20 citation statements)

References 39 publications

(42 reference statements)

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“…However, under different circumstances such as dialysis or i.v. administration, Al can reach toxicological levels in plasma [7]. This situation is more relevant when the excretion rate is altered such as during impaired renal function.…”

Section: Introductionmentioning

confidence: 99%

The Interactions between the Chronic Exposure to Aluminum and Liver Regeneration on Bile Flow and Organic Anion Transport in Rats

González

Bernal

Mahieu

et al. 2008

Biol Trace Elem Res

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The chronic exposure to Aluminum (Al) may compromise different liver functions, mainly during the hepatic regeneration. The aim of this study is to investigate the interactions between the chronic i.p. exposure to Al and hepatic regeneration (HR) on bile flow and organic anion transport in experimental animals. For this purpose, we studied bile flow and fractional transfer rates for the transport of hepatic organic anions (hepatic uptake, sinusoidal efflux, and canalicular excretion), as well as parameters related with the oxidative stress (OS), on rats chronically treated with Al at 0 and 2 days of HR. The Al treatment and time of HR caused a decrease in the biliary flow and in the hepatic uptake and canalicular excretion constants. In addition, Al and HR increased the lipoperoxidation associated with a reduction of the glutathione content and glutathione peroxidase and catalase enzyme's activities. Since the effects of Al and HR on biliary flow and transport systems were additive, but not on the oxidative status, different mechanisms might be involved on these alterations. Even though the OS may play a key role on the hepatic deleterious effects, there is no unique cause-effect relationship between OS and liver dysfunction in this experimental animal model.

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Section: Introductionmentioning

confidence: 99%

The Interactions between the Chronic Exposure to Aluminum and Liver Regeneration on Bile Flow and Organic Anion Transport in Rats

González

Bernal

Mahieu

et al. 2008

Biol Trace Elem Res

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“…It is reported that chronic accumulation of aluminium might induce nephrotoxicity without important changes in global renal function but by modifying the cellular regulation of renal functions such as transport and metabolism [62]. Transport and metabolism in the kidneys cannot be discussed without referencing the RAAS which functions to regulate volume of body fluids, solutes, pH and to concentrate the urine above plasma.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation in the expression of renin gene by the influence of aluminium

Ezomo

Matsushima

Meshitsuka

2009

Journal of Inorganic Biochemistry

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The excretion of aluminium in urine was significantly increased after intake of analgesics containing aluminium, confirming increased absorption and hence exposure to aluminium with such medication. The effect of aluminium on the kidney was further investigated by study of gene expression in mice. After a single dose of aluminium, an up-regulation of renin gene was found by DNA sequencing of the products of differential display analysis. The up-regulation of renin was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting experiments in the dose dependent treatments and the time course observation after aluminium citrate injection. The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.

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“…Aluminum-induced depletion of antioxidants such as glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and catalase (CAT) (Mahieu et al, 2005). Antioxidants thus play key roles in the protection against damage caused by reactive oxygen species (Baynes, 1991).…”

Section: Biology Department College Ofmentioning

confidence: 99%

POTENTIAL ROLE OF Jasonia montanta AND Jasonia candicans AGAINST ALZHEIMER'S DISEASE: ASSESSMENT OF OXIDATIVE STRESS AND GENE EXPRESSION CHANGES IN AD-INDUCED RATS

Linjawi

Ahmed

Khalil

et al. 2011

Egyptian Journal of Genetics and Cytology

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Alterations of the renal function and oxidative stress in renal tissue from rats chronically treated with aluminium during the initial phase of hepatic regeneration

Cited by 35 publications

References 39 publications

The Interactions between the Chronic Exposure to Aluminum and Liver Regeneration on Bile Flow and Organic Anion Transport in Rats

The Interactions between the Chronic Exposure to Aluminum and Liver Regeneration on Bile Flow and Organic Anion Transport in Rats

Up-regulation in the expression of renin gene by the influence of aluminium

POTENTIAL ROLE OF Jasonia montanta AND Jasonia candicans AGAINST ALZHEIMER'S DISEASE: ASSESSMENT OF OXIDATIVE STRESS AND GENE EXPRESSION CHANGES IN AD-INDUCED RATS

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