Alterations of structural and functional connectivity in profound sensorineural hearing loss infants within an early sensitive period: A combined DTI and fMRI study

Wang, Shanshan; Chen, Boyu; Yu, Yalian; Yang, Hui; Cui, Wenzhuo; Li, Jian; Fan, Guoguang

doi:10.1016/j.dcn.2019.100654

Cited by 39 publications

(44 citation statements)

References 68 publications

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“…HARDI theoretically enables better differentiation within a voxel by utilizing information about water diffusivity from many more directions than DTI (Tuch et al, 2002). The white matter fibers in SNHL have been analyzed in only a few studies using tract‐based spatial statistics (TBSS), which showed lower FA values of the bilateral AF, UF, ILF, and IFOF in profound SNHL patients aged below 4 years (Park et al., 2018; Wang, Chen, et al., 2019). In contrast, other measurements (volume, lengths, and ADC values) of long association fibers in SNHL have not been focused on so far.…”

Section: Discussionmentioning

confidence: 99%

“…Fx, right 0.026 F = 0.79, p = .54 F = 2.4, p = .13 F = 0.18, p = .67 F = 0.26, p = .62 CP 0.020 F = 1.2, p = .35 F = 2.8, p = .10 F = 0.30, p = .59 F = 0.84, p = .37 ADC AF, left 0.270 F = 4.1, p = .01 F = 9.0, p = 5.4 × 10 −3 F = 3.6, p = .068 F = 4.0, p = .054 AF, right 0.279 F = 4.2, p = 8.4 × 10 −3 F = 10.2, p = 3.4 × 10 −3 F = 2.8, p = .11 F = 4.3, p = .046 (Continues) 4 years (Park et al, 2018;Wang, Chen, et al, 2019). In contrast, other measurements (volume, lengths, and ADC values) of long association fibers in SNHL have not been focused on so far.…”

Section: Hardi Tractographymentioning

confidence: 97%

“…In contrast to cortical morphometry studies using T1‐weighted images, there are only a few studies concerning diffusion MRI in children with SNHL (Chang et al., 2012; Jiang et al., 2019; Park et al., 2018; Wang, Chen, et al., 2019; Wang, Liang, et al., 2019; Wu et al., 2016). These studies mainly focus on fractional anisotropy (FA) values in auditory pathways (lemniscus lateralis, inferior colliculus, medial geniculate bodies, and auditory radiations) and speech composition centers (e.g., Broca's gyrus, and Heschl's gyrus), and there is no quantitative study of tractography‐based long association fibers to our best knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative analyses of high‐angular resolution diffusion imaging (HARDI)‐derived long association fibers in children with sensorineural hearing loss

Shiohama

Chew

Levman

et al. 2020

Intl J of Devlp Neuroscience

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Sensorineural hearing loss (SNHL) is the most common developmental sensory disorder due to a loss of function within the inner ear or its connections to the brain. While successful intervention for auditory deprivation with hearing amplification and cochlear implants during a sensitive early developmental period can improve spoken-language outcomes, SNHL patients can suffer several cognitive dysfunctions including executive function deficits, visual cognitive impairment, and abnormal visual dominance in speaking perception even after successful intervention. To evaluate whether long association fibers are involved in the pathogenesis of impairment on the extra-auditory cognitive process in SNHL participants, we quantitatively analyzed high-angular resolution diffusion imaging (HARDI) tractography-derived fibers in participants with SNHL. After excluding cases with congenital disorders, perinatal brain damage, or premature birth, we enrolled 17 participants with SNHL aged under 10 years old. Callosal pathways (CP) and six types of cortico-cortical association fibers (arcuate fasciculus [AF], inferior longitudinal fasciculus [ILF], inferior frontooccipital fasciculus [IFOF], uncinate fasciculus [UF], cingulum fasciculus [CF], and fornix [Fx]) in both hemispheres were identified and visualized. The ILF and IFOF were partly undetected in three profound SNHL participants. Compared to age-and gender-matched neurotypical controls (NC), decreased volumes, increased lengths, and high apparent diffusion coefficient (ADC) values without difference in fractional anisotropy (FA) values were identified in multiple types of fibers in the SNHL group. The impairment of long association fibers in SNHL may partly be related to the association of cognitive dysfunction with SNHL. K E Y W O R D S apparent diffusion coefficient, fractional anisotropy, high-angular resolution diffusion imaging, long association fibers, sensorineural hearing loss How to cite this article: Shiohama T, Chew B, Levman J, Takahashi E. Quantitative analyses of high-angular resolution diffusion imaging (HARDI)derived long association fibers in children with sensorineural hearing loss.

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Section: Discussionmentioning

confidence: 99%

Section: Hardi Tractographymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Quantitative analyses of high‐angular resolution diffusion imaging (HARDI)‐derived long association fibers in children with sensorineural hearing loss

Shiohama

Chew

Levman

et al. 2020

Intl J of Devlp Neuroscience

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“…Of interest, sensorineural hearing impairment, sometimes with normal or near-normal sound detection ('hidden hearing loss'), has been described in CMT1A patients, reflecting neural conduction abnormalities in the afferent auditory pathway due to auditory neuropathy and negatively affecting speech perception and understanding [31,32]. Indeed, other forms of sensorineural hearing loss [33,34], as well as sensory deprivation in other domains (e.g. visual deficits [35]), have been shown to induce reorganization of the brain FC in a top-down modulatory effort.…”

Section: Discussionmentioning

confidence: 99%

Diffuse brain connectivity changes in Charcot–Marie–Tooth type 1a patients: a resting‐state functional magnetic resonance imaging study

Pontillo

Tozza

Perillo

et al. 2020

Euro J of Neurology

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Background and purpose: Changes of brain structure and function have been described in peripheral neuropathies. The aim of our study was to systematically investigate possible modifications of major large-scale brain networks using resting-state functional magnetic resonance imaging (RS-fMRI) in Charcot-Marie-Tooth disease type 1A (CMT1A) patients. Methods: In this cross-sectional study, 3-T MRI brain scans were acquired of right-handed genetically confirmed CMT1A patients and age-and sex-comparable healthy controls. Patients also underwent clinical and electrophysiological examinations assessing neurological impairment. RS-fMRI data were analysed using a seed-based approach, with 32 different seeds sampling the main hubs of default mode, sensorimotor, visual, salience (SN), dorsal attention, frontoparietal, language and cerebellar networks. Between-group differences in terms of functional connectivity (FC) with the explored seeds were tested voxelwise, correcting for local grey matter density to account for possible structural abnormalities, whilst the relationship between FC modifications and neurological impairment was investigated using robust correlation analyses. Results: Eighteen CMT1A patients (34.0 AE 11.4 years; M/F 11/7) were enrolled, along with 20 healthy controls (30.1 AE 10.2 years; M/F 11/9). In the CMT group compared to controls, clusters of increased FC with the visual cortex (P = 0.001), SN (P < 6 9 10 À4), dorsal attention network (P < 8 9 10 À5) and language network (P < 7 9 10-4) were found, along with a single cluster of reduced FC with the visual cortex in the left lentiform nucleus (P = 10-6). A significant correlation emerged between neurophysiological impairment and increased FC with right temporal language areas (r = 0.655, P = 0.006), along with an association between walking ability and increased FC with the left supramarginal gyrus (SN) (r = 0.620, P = 0.006). Conclusions: Our data show evidence of diffuse functional reorganization involving multiple large-scale networks in the CMT1A brain, independent of structural modifications and partially correlating with peripheral nerve damage and functional impairment.

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“…In addition to conventional MR sequences, some advanced techniques such as diffusion tensor imaging (DTI) and functional MR imaging (fMRI), may be helpful to provide new insight into structural and functional white matter changes in early stage of congenital SNHL [28]. On the other hand, the investigation of the first step of the central auditory pathway, i.e.…”

Section: Auditory Central Nervous Systemmentioning

confidence: 99%

The Site of Lesion in Hearing Loss: Advances in Otoneuroradiology

Conte¹,

Casale²,

Sbaraini³

et al. 2020

Advances in Rehabilitation of Hearing Loss

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The last decade has witnessed significant advances in imaging of the middle and inner ear and the auditory pathways. High resolution computerized tomography (CT) scanners and new magnetic resonance (MR) sequences have been implemented in clinical practice as valuable supportive tools for the Audiologist in the identification of the site of lesion and for the surgical planning by the Otologist. The purpose of this chapter is to review the current advanced methods of neuroradiological evaluation of patients with sensorineural hearing loss (SNHL), either congenital or acquired, especially focusing on the assessment of candidates to cochlear implantation (CI), with plenty of explicative images.

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Alterations of structural and functional connectivity in profound sensorineural hearing loss infants within an early sensitive period: A combined DTI and fMRI study

Cited by 39 publications

References 68 publications

Quantitative analyses of high‐angular resolution diffusion imaging (HARDI)‐derived long association fibers in children with sensorineural hearing loss

Quantitative analyses of high‐angular resolution diffusion imaging (HARDI)‐derived long association fibers in children with sensorineural hearing loss

Diffuse brain connectivity changes in Charcot–Marie–Tooth type 1a patients: a resting‐state functional magnetic resonance imaging study

The Site of Lesion in Hearing Loss: Advances in Otoneuroradiology

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