Alterations of mitochondrial phospholipids in the rat brown adipose tissue after chronic treatment with cold or thyroxine

Ricquier, Daniel; Mory, G.; Hemon, P.

doi:10.1016/0014-5793(75)80051-2

Cited by 48 publications

(8 citation statements)

References 16 publications

(2 reference statements)

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“…Therefore, it is likely that unsaturation in CL is more closely associated with an enhanced NST in BAT. RICQUIER et al (1975) also reported alterations of FA distribution of BAT-CL in CA: a decrease of C18: 1 and an increase of C18 :2, which did not correspond to the present results. PU of PL-FA rather decreased in the red quadriceps of CA and 25G, and in the soleus of 25G, while significant increases in MU of CL-FA of red quadriceps of CA, and in that of red as well as white quadriceps of 25G were found (Fig.…”

Section: Discussioncontrasting

confidence: 99%

Muscle and brown adipose tissue fatty acid profiles in cold-exposed rats.

1987

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Effects of cold acclimation and cold exposure for 25 generations on triglyceride (TG)-, total phospholipid (PL)-, and cardiolipin (CL)-fatty acid (FA) compositions were studied in the different types of skeletal muscles (red and white muscles from quadriceps, and soleus) as well as brown adipose tissue (BAT) in rats. TG: in cold-acclimated rats (CA) and rats reared in cold for 25 generations (25G) white muscle showed the decreased saturated FA (SA) and increased polyunsaturated FA (PU). In soleus of 25G, monounsaturated FA (MU) and PU increased, and SA decreased. In BAT, SA increased and MU decreased in CA, and SA and PU decreased, and MU increased in 25G. PL: in red muscle of CA, SA increased and PU decreased. In red muscle of 25G the similar but more marked changes were found accompanied by lowered arachidonic acid and unsaturation index (UI). In BAT, SA, PU, arachidonic acid, and UI increased in CA, and arachidonic acid increased in 25G. CL: in red and white muscles of 25G, oleic acid and MU increased. In BAT, arachidonic acid increased in CA and 25G, and UI increased in 25G. These results suggest that FA unsaturation of CL in the muscles as well as BAT is involved in an enhanced thermogenesis in cold-exposed rats.

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Section: Discussioncontrasting

confidence: 99%

Muscle and brown adipose tissue fatty acid profiles in cold-exposed rats.

1987

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“…7C). The elevation in the content of both 18:2 and 20:4-6 in brown fat in response to cold exposure has been repeatedly shown in mitochondria of brown fat (33)(34)(35), and we show here that the level of only one of these (20:4-6) was mitigated by group housing.…”

Section: Methodssupporting

confidence: 81%

Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice

Maher

Barbash

Lynch

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Maher RL, Barbash SM, Lynch DV, Swoap SJ. Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol 308: R1070 -R1079, 2015. First published April 15, 2015 doi:10.1152/ajpregu.00407.2014.-Huddling and nest building are two methods of behavioral thermoregulation used by mice under cold stress. In the laboratory, mice are typically housed at an ambient temperature (T a) of 20°C, well below the lower end of their thermoneutral zone. We tested the hypothesis that the thermoregulatory benefits of huddling and nest building at a T a of 20°C would ameliorate this cold stress compared with being singly housed at 20°C as assessed by heart rate (HR), blood pressure (BP), triiodothyronine (T3), brown adipose (BAT) expression of Elovl3 mRNA, and BAT lipid content. A series of experiments using C57BL/6J female mice exposed to 20°C in the presence or absence of nesting material and/or cage mates was used to test this hypothesis. Mice showed large differences in HR, BP, shivering, and core body temperature (T b) when comparing singly housed mice at 20°C and 30°C, but only a modest reduction in HR with the inclusion of cage mates or bedding. However, group housing and/or nesting at 20°C decreased T3 levels compared with singly housed mice at 20°C. Singly housed mice at 20°C had a 22-fold higher level of BAT Elovl3 mRNA expression and a significantly lower triacylglycerol (TAG) content of BAT compared with singly housed mice at 30°C. Group housing at 20°C led to blunted changes in both Elovl3 mRNA and TAG levels. These findings suggest that huddling and nest building have a limited effect to ameliorate the cold stress associated with housing at 20°C. ambient temperature; blood pressure; brown fat; nesting THE MOUSE (MUS MUSCULUS) IS an important model system for mammalian studies. Its genetic tractability with a short reproductive time, coupled with advances in the miniaturization of physiological tools, create an increased ease for the merging of physiological studies and "omic" studies. The ambient temperature (T a ) of animal housing facilities is within a standard range that, while comfortable for human caretakers, falls well below the mouse thermoneutral zone (TNZ), the range of T a s in which endotherms do not elevate their metabolic rate to maintain core body temperature (T b ) (19, 23). The T a at which metabolic rate begins to rise to offset heat loss (i.e., the lower critical temperature) is ϳ29 -30°C for mice (18). Housed at temperatures below this zone, mice are under cold stress (8).To elevate metabolic rate and minimize heat loss when exposed to cooler temperatures, endotherms engage one of many behavioral changes and/or several physiological adaptations, which vary across species and which are not mutually exclu-

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“…This marked alteration was first observed in the 1970s (15,46,52), and since then, many studies have verified qualitatively identical alterations in animals of different species and different ages (detailed in the DISCUSSION). In particular, increases in the content of certain polyunsaturated acyl groups, especially linoleic acid, 18:2(n-6), and arachidonic acid, 20:4(n-6), have been observed consistently.…”

mentioning

confidence: 70%