Alterations of miR-132 are novel diagnostic biomarkers in peripheral blood of schizophrenia patients

Yu, Haichuan; Wu, Jiao; Zhang, Hongxing; Zhang, Gao-li; Sui, Juan; Tong, Wenwen; Zhang, Xin-Ya; Nie, Lili; Duan, Jinlong; Zhang, Lirong; Lv, Luxian

doi:10.1016/j.pnpbp.2015.05.007

Cited by 52 publications

(31 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MicroRNAs (miRNAs) are 20-25 nucleotide long, single-stranded, nonprotein-coding RNA molecules that regulate protein expression levels [2,96]. There is evidence of a key role for miRNAs in neurogenesis, neural maturation and brain development [96,97].…”

Section: Hormones Possible Biological Markers?mentioning

confidence: 99%

“…There is evidence of a key role for miRNAs in neurogenesis, neural maturation and brain development [96,97]. Thus, dysfunction in miRNA signaling contributes to neurodegenerative and psychiatric disorders [2]. A number of circulating miRNAs was quantified in the serum of first-onset SCZ patients and that of healthy individuals [2,98].…”

Section: Hormones Possible Biological Markers?mentioning

confidence: 99%

“…Thus, dysfunction in miRNA signaling contributes to neurodegenerative and psychiatric disorders [2]. A number of circulating miRNAs was quantified in the serum of first-onset SCZ patients and that of healthy individuals [2,98]. In a recent study aiming to identify miRNAs that are clinically practicable biomarkers, it was observed a significant decrease in miR-132 in the PBMCs of SCZ patients compared with controls [2].…”

Section: Hormones Possible Biological Markers?mentioning

confidence: 99%

“…A number of circulating miRNAs was quantified in the serum of first-onset SCZ patients and that of healthy individuals [2,98]. In a recent study aiming to identify miRNAs that are clinically practicable biomarkers, it was observed a significant decrease in miR-132 in the PBMCs of SCZ patients compared with controls [2]. Moreover, miR-132 was previously found to be significantly downregulated in prefrontal cortical tissue in SCZ patients [99].…”

Section: Hormones Possible Biological Markers?mentioning

confidence: 99%

“…Schizophrenia (SCZ) is a heterogeneous psychiatric disorder of still unclear pathophysiological mechanisms, resulting from a complex interplay between genetic variants and environmental factors [1,2]. It affects more than 21 million people worldwide [3], being characterised by heterogeneous clinical symptomatology such as delusions, hallucinations, thought disorders and behavioural and emotional changes, with progressive cognitive decline and deterioration of personality [4].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

View full text Add to dashboard Cite

Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

show abstract