Alterations of intrauterine eicosanoid production in pregnancy-induced hypertension: Decreased production of 12-hydroxyeicosatetraenoic acid in the placenta

Arbogast, Eva; Schäfer, Wolfgang; Zahradnik, H. P.

doi:10.1016/0090-6980(95)00183-2

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…As compared to uncomplicated preterm labor, the LT output increases markedly in chorioamnionitisassociated preterm labor. More recently, Brown et al, [81] noted the expression of 5-LO and 5-LO activating protein (FLAP) mRNA in the choriondecidua to be significantly higher in the first trimester of pregnancy than in the second and third LO, has been implicated in various pregnancy disorders such as preeclampsia [75][76][77][78][79]. LTB 4 production is relatively high in early normal pregnancy (7 to 12 weeks gestation), but remains trimesters.…”

Section: Occurrence Of Lomentioning

confidence: 99%

Role of Biotransformation in Conceptal Toxicity of Drugs and Other Chemicals

Kulkarni

2001

CPD

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Many developmental toxicants and teratogens require prior metabolism to reactive species or free radicals to exert toxicity. Thus the knowledge of conceptal biotransformation is absolutely critical in understanding toxicity of these chemicals. Due to extremely low content of cytochrome P450 in the embryo and other conceptal tissues, the research focus in recent years has steadily shifted toward enzymes capable of peroxidative oxidation of xenobiotics. At least three enzymes viz. lipoxygenase, peroxidase and prostaglandin synthase, each capable of peroxidative xenobiotic metabolism, occur in conceptal tissues of man and laboratory animals in biologically significant amounts. This review mainly summarizes the available information on the enzymatic bioactivation of teratogens and developmental toxicants belonging to diverse classes such as drugs, pesticides, environmental contaminants, industrial and other chemicals. Additionally, some discussion is devoted toward issues such as drug-drug interactions. The emerging new information on the peroxidative glutathione conjugate formation from xenobiotics is also presented. A critical need for gathering more information on this subject using different enzyme preparations from human conceptal tissues is stressed to avoid tragedies in the future.

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Section: Occurrence Of Lomentioning

confidence: 99%

Role of Biotransformation in Conceptal Toxicity of Drugs and Other Chemicals

Kulkarni

2001

CPD

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“…The 12/15‐LOX metabolite, 12‐HETE, was the most prevalent, exhibiting increased production with the progression of labor 73. Furthermore, the placental release of 12‐HETE was significantly decreased in pregnancy‐induced hypertension (PIH),74 suggesting 12/15‐LOX participation in controlling the intrauterine eicosanoid environment in response to physiological stress. Therefore, AA metabolites of both the COX and LOX pathways may participate in the control of fetal and placental hemodynamics and could be relevant targets for disorders like pre‐eclampsia where placental hemodynamics are altered.…”

Section: Placental Fatty Acid Metabolismmentioning

confidence: 99%

Effect of Placental Fatty Acid Metabolism and Regulation by Peroxisome Proliferator Activated Receptor on Pregnancy and Fetal Outcomes

Wang

Cook

et al. 2007

Journal of Pharmaceutical Sciences

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“…The role of decreased PGE 2 and PGF 2␣ and increased TXA 2 (and/or its precursors) and endothelins in plasma, urine, placenta and even platelets has gained importance in the pathogenesis of HT and altered renal function that accompanies pre-eclampsia. 21,35,[42][43][44][45] In summary, PGs play a conspicuous role in many body functions, blood pressure regulation being among the most studied. Their widespread distribution, multiple effects, and interactions make them sufficiently attractive to be considered as meaningful in the pathogenic, diagnosis and therapy of several types of human HT, avoiding the risk of oversimplification of their role and actions.…”

Section: Figurementioning

confidence: 99%