1993
DOI: 10.1111/j.1460-9568.1993.tb00919.x
|View full text |Cite
|
Sign up to set email alerts
|

Alterations of G‐protein Coupling Function in Phosphoinositide Signalling Pathways of Rat Hippocampus by Ischaemic Brain Injury

Abstract: The activation of membrane-associated phospholipase C is rapidly and transiently induced in the central nervous system by a variety of stimuli. Ischaemic brain injury is one of the situations that leads to a dramatic increase in polyphosphoinositide (PPI) turnover. In this study, stimulation of PPI hydrolysis by glutamate (500 microM) was measured in hippocampal slices from rats up to 21 days after an ischaemic insult of 30 min. Ischaemia was induced using the four-vessel occlusion method. PPI hydrolysis elici… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

1996
1996
2016
2016

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(3 citation statements)
references
References 25 publications
0
3
0
Order By: Relevance
“…Under the catalysis of PLC, phosphatidylinositol biphosphate (PIP2) decomposes into inositol triphosphate (IP3) and diacylglycerol (DG), which afects two branches of this pathway respectively (Kim NH et al, 2011). The extracellular signals that stimulate the metabolism of PIP2 include neurotransmitter (oxy-choline-type acetylcholine, α1-adrenaline, 5-HT and H1 histamine), some polypeptide hormones (V1 vasopressin, angiotonin II, substance P and thyrotrophin releasing factor), and growth factor (PDGF and T-cell mitogen) (Lu YM et al, 1993). IP3, is a kind of small water solubility molecule, can be diffused rapidly and leave from the cellular membrane.…”
Section: Phospholipase C Signal Transduction Pathway (Plc)mentioning
confidence: 99%
See 1 more Smart Citation
“…Under the catalysis of PLC, phosphatidylinositol biphosphate (PIP2) decomposes into inositol triphosphate (IP3) and diacylglycerol (DG), which afects two branches of this pathway respectively (Kim NH et al, 2011). The extracellular signals that stimulate the metabolism of PIP2 include neurotransmitter (oxy-choline-type acetylcholine, α1-adrenaline, 5-HT and H1 histamine), some polypeptide hormones (V1 vasopressin, angiotonin II, substance P and thyrotrophin releasing factor), and growth factor (PDGF and T-cell mitogen) (Lu YM et al, 1993). IP3, is a kind of small water solubility molecule, can be diffused rapidly and leave from the cellular membrane.…”
Section: Phospholipase C Signal Transduction Pathway (Plc)mentioning
confidence: 99%
“…The extracellular signals that stimulate the metabolism of PIP2 include neurotransmitter (oxy‐choline‐type acetylcholine, α1‐adrenaline, 5‐HT and H1 histamine), some polypeptide hormones (V1 vasopressin, angiotonin II, substance P and thyrotrophin releasing factor), and growth factor (PDGF and T‐cell mitogen) (Lu YM et al, 1993). IP3, is a kind of small water solubility molecule, can be diffused rapidly and leave from the cellular membrane.…”
Section: Introductionmentioning
confidence: 99%
“…Phospholipase C (PLC) activation is thought to be responsible for the hypoxia-ischemiainduced polyphosphoinositide hydrolysis (15,16). Michell (17) proposed that polyphosphoinositide turnover is one of the earliest intracellular signaling events, preceding and perhaps initiating mobilization of intracellular calcium from storage compartments.…”
Section: ‫ם2‬mentioning
confidence: 99%