1997
DOI: 10.1016/s0006-8993(97)00311-9
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Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses

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Cited by 20 publications
(7 citation statements)
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“…These data suggest that a modest concentration of thrombin (30 n m ) was relatively selective for PAR1 activation, since removal or block of PAR1 eliminated the intracellular Ca 2+ response in cultured astrocytes. These results are consistent with a number of previous reports in the literature suggesting that thrombin stimulates Ca 2+ mobilization in neurones and glia (Smith‐Swintosky et al 1995; Yang et al 1997; Smirnova et al 1998; Wang et al 2002 a , b ; Suo et al 2002; Sorensen et al 2003; Junge et al 2004; Nicole et al 2005). The TFLLR‐induced astrocytic Ca 2+ responses persisted in the absence of external Ca 2+ (Fig.…”
Section: Resultssupporting
confidence: 93%
See 1 more Smart Citation
“…These data suggest that a modest concentration of thrombin (30 n m ) was relatively selective for PAR1 activation, since removal or block of PAR1 eliminated the intracellular Ca 2+ response in cultured astrocytes. These results are consistent with a number of previous reports in the literature suggesting that thrombin stimulates Ca 2+ mobilization in neurones and glia (Smith‐Swintosky et al 1995; Yang et al 1997; Smirnova et al 1998; Wang et al 2002 a , b ; Suo et al 2002; Sorensen et al 2003; Junge et al 2004; Nicole et al 2005). The TFLLR‐induced astrocytic Ca 2+ responses persisted in the absence of external Ca 2+ (Fig.…”
Section: Resultssupporting
confidence: 93%
“…2) as well as with other reports in the literature (e.g. Yang et al 1997), but is lower than our previous estimate of ∼40% of thrombin responsive neurones in cultures prepared from the entire hippocampal formation plus dentate gyrus (13% respond to thrombin + inhibitor, 54% respond to 30 n m thrombin; Gingrich et al 2000). This discrepancy likely reflects higher PAR1 expression in dentate granule neurones than in CA1 neurones (Weinstein et al 1995).…”
Section: Resultssupporting
confidence: 44%
“…Thrombin acted specifically, because it affected neither the distribution of surface L1 nor that of NrCAM bearing a noncleavable GFP-tag ( Figure 1E). Although hippocampal neurons express thrombin receptors (Yang et al, 1997), thrombin can induce significant effects only when applied at much higher concentrations and for longer times than the times used here (Brewer, 1996;Donovan et al, 1997). Indeed, thrombin did not alter growth cone motility or cause neurite retraction in our conditions ( Figure 5).…”
Section: Surface Expression and Exocytosis Of L1-gfp Moleculesmentioning
confidence: 80%
“…Additionally, PAR-I's existence at the neural cell surface has been inferred for some time based on morphologic, physiologic, and biochemical responses to both thrombin and PAR-I activating peptides (Jatink and Moolenaar, 1992;Suidan et al, 1992;Beecher et al, 1994;Grabham and Cunningham, 1995;Smith-Swintosky et al, 1995;Vaughan et at., 1995;Yang et al, 1997). In the present study, PAR-I cell surface expression is directly demonstrated and quantitated in a human neural cell line (Ad12 HER 10).…”
Section: Par-i Cell Surface Expression May Allow For Both Normal Devementioning
confidence: 83%