Alterations of functional connectivity between thalamus and cortex before and after decompression in cervical spondylotic myelopathy patients: a resting-state functional MRI study

Peng, Xinji; Tan, Yongming; He, Laichang; Ou, Yangtao

doi:10.1097/wnr.0000000000001346

Cited by 24 publications

(28 citation statements)

References 33 publications

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“…They found that the functional connectivity within the visual network and the functional connectivity between secondary visual cortices and cerebellum were significantly increased in CSM patients (27). These results are consistent with previous studies, where there was decreased regional neural activities and enhanced connectivity (4,7,69). These intrinsic functional changes in the patients with CSM can be associated with functional reorganization and reflects the innate cortical plasticity in patients with CSM.…”

Section: Increased Functional Connectivity and Dmn Global Efficiency supporting

confidence: 85%

“…Cervical spondylotic myelopathy (CSM) is commonly observed in clinical practice, and its severity depends on the pathophysiological effects on the spinal cord (1)(2)(3). However, emerging evidence suggest that cortical alterations may also be crucial in CSM pathology (4)(5)(6)(7). It has been shown that the cortical alterations can only partly restore after decompression surgery (8,9), and the preoperative neural activities can be used as a potential biomarker to predict surgical outcomes (10).…”

Section: Introductionmentioning

confidence: 99%

“…This technique measures blood-oxygenation-level-dependent (BOLD) signals and is used to study brain functional alterations in diseases like Alzheimer's disease (AD), Parkinson's disease (PD), epilepsy, attention-deficit hyperactivity disorder (ADHD), and mood disorders (16)(17)(18)(19)(20)(21)(22)(23). In neuroimaging studies of CSM, fMRI has illuminated functional alterations in motor cortices (4,7,10,24,25). Using resting-state fMRI (rs-fMRI), we have previously identified alterations in functional connectivity in visual cortices that correlate with visual and motor function in CSM patients (26,27).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neural Correlates of Cognitive Dysfunctions in Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study

Zhao

et al. 2020

Front. Neurol.

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Cervical spondylotic myelopathy (CSM) is a common disease of the elderly that is characterized by gait instability, sensorimotor deficits, etc. Recurrent symptoms including memory loss, poor attention, etc. have also been reported in recent studies. However, these have been rarely investigated in CSM patients. To investigate the cognitive deficits and their correlation with brain functional alterations, we conducted resting-state fMRI (rs-fMRI) signal variability. This is a novel indicator in the neuroimaging field for assessing the regional neural activity in CSM patients. Further, to explore the network changes in patients, functional connectivity (FC) and graph theory analyses were performed. Compared with the controls, the signal variabilities were significantly lower in the widespread brain regions especially at the default mode network (DMN), visual network, and somatosensory network. The altered inferior parietal lobule signal variability positively correlated with the cognitive function level. Moreover, the FC and the global efficiency of DMN increased in patients with CSM and positively correlated with the cognitive function level. According to the study results, (1) the cervical spondylotic myelopathy patients exhibited regional neural impairments, which correlated with the severity of cognitive deficits in the DMN brain regions, and (2) the increased FC and global efficiency of DMN can compensate for the regional impairment.

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Section: Increased Functional Connectivity and Dmn Global Efficiency supporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neural Correlates of Cognitive Dysfunctions in Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study

Zhao

et al. 2020

Front. Neurol.

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“…Interestingly, recent studies have shown an association between DCM and cerebral reorganization, seemingly to compensate for functional impairment. The majority of studies have focused on cortical reorganization, however similar changes have been observed in the brainstem [9] and the thalamus [10]. This reorganization has been seen across a number of modalities, including arterial spin labelling functional MRI (fMRI) [11], blood oxygen level dependent (BOLD) fMRI [10,12], and navigated transcranial magnetic stimulation (nTMS) [13].…”

Section: Topics 21 Pathophysiologymentioning

confidence: 97%

Degenerative Cervical Myelopathy: Clinical Presentation, Assessment, and Natural History

Lannon

Kachur

2021

JCM

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Degenerative cervical myelopathy (DCM) is a leading cause of spinal cord injury and a major contributor to morbidity resulting from narrowing of the spinal canal due to osteoarthritic changes. This narrowing produces chronic spinal cord compression and neurologic disability with a variety of symptoms ranging from mild numbness in the upper extremities to quadriparesis and incontinence. Clinicians from all specialties should be familiar with the early signs and symptoms of this prevalent condition to prevent gradual neurologic compromise through surgical consultation, where appropriate. The purpose of this review is to familiarize medical practitioners with the pathophysiology, common presentations, diagnosis, and management (conservative and surgical) for DCM to develop informed discussions with patients and recognize those in need of early surgical referral to prevent severe neurologic deterioration.

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“…However, the CSM was a special incomplete SCI, and whether the CSM patients had similar topological properties to those patients with SCI is worth exploring. Previous neuroimaging CSM studies have found a correlation between disease symptoms and functional connectivity in specific resting-state brain regions or networks and indicated the human brain connectome as an underlying biomarker of CSM (16,24). A recent study based on topological characteristics of the structural network in CSM patients found a lower Cp and shorter characteristic path length (Lp) in the brain structural covariance network (25).…”

Section: Introductionmentioning

confidence: 99%

Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy

Cao¹,

Zhan²,

et al. 2021

Quant Imaging Med Surg

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Background: Brain functional plasticity and reorganization in patients with cervical spondylotic myelopathy (CSM) is increasingly being explored and validated. However, specific topological alterations in functional networks and their role in CSM brain functional reorganization remain unclear. This study investigates the topological architecture of intrinsic brain functional networks in CSM patients using graph theory.Methods: Functional MRI was conducted on 67 CSM patients and 60 healthy controls (HCs). The topological organization of the whole-brain functional network was then calculated using theoretical graph analysis. The difference in categorical variables between groups was compared using a chi-squared test, while that between continuous variables was evaluated using a two-sample t-test. Nonparametric permutation tests were used to compare network measures between the two groups.Results: Small-world architecture in functional brain networks were identified in both CSM patients and HCs. Compared with HCs, CSM patients showed a decreased area under the curve (AUC) of the characteristic path length (FDR q=0.040), clustering coefficient (FDR q=0.037), and normalized characteristic path length (FDR q=0.038) of the network. In contrast, there was an increased AUC of normalized clustering coefficient (FDR q=0.014), small-worldness (FDR q=0.009), and global network efficiency (FDR q=0.027) of the network. In local brain regions, nodal topological properties revealed group differences which were predominantly in the default-mode network (DMN), left postcentral gyrus, bilateral putamen, lingual gyrus, and posterior cingulate gyrus. Conclusions: This study reported altered functional topological organization in CSM patients. Decreased nodal centralities in the visual cortex and sensory-motor regions may indicate sensory-motor dysfunction and blurred vision. Furthermore, increased nodal centralities in the cerebellum may be compensatory for sensory-motor dysfunction in CSM, while the increased DMN may indicate increased psychological processing in CSM patients.

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Alterations of functional connectivity between thalamus and cortex before and after decompression in cervical spondylotic myelopathy patients: a resting-state functional MRI study

Cited by 24 publications

References 33 publications

Neural Correlates of Cognitive Dysfunctions in Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study

Neural Correlates of Cognitive Dysfunctions in Cervical Spondylotic Myelopathy Patients: A Resting-State fMRI Study

Degenerative Cervical Myelopathy: Clinical Presentation, Assessment, and Natural History

Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy

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