Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations

Pérez-Rando, Marta; Elvira, Uriel K.A.; García-Martí, Gracián; Gadea, Marién; Aguilar, Eduardo J.; Escartí, María J.; Ahulló-Fuster, Mónica Alba; Grasa, Eva; Corripio, Iluminada; Sanjuán, Julio; Nácher, Juan

doi:10.1016/j.nicl.2022.103070

Cited by 20 publications

(7 citation statements)

References 79 publications

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“…These findings are consistent with recent volumetric analyses of thalamic nuclear regions comparing schizophrenia and bipolar disorder and schizophrenia with and without hallucinations to healthy controls, which identified significant associations with the MD, Pul, LGN, and MGN (Mørch-Johnsen et al 2023; Perez-Rando et al 2022). In addition, we have identified volumetric reductions affecting the VA, VLP, and CM.…”

Section: Discussionsupporting

confidence: 91%

Normative modeling of thalamic nuclear volumes

Young,

Kumar,

Saranathan

2024

Preprint

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Thalamic nuclei have been implicated in neurodegenerative and neuropsychiatric disorders. Normative models for thalamic nuclear volumes have not been proposed thus far. The aim of this work was to establish normative models of thalamic nuclear volumes and subsequently investigate changes in thalamic nuclei in cognitive and psychiatric disorders. Volumes of the bilateral thalami and 12 nuclear regions were generated from T1 MRI data using a novel segmentation method (HIPS-THOMAS) in healthy control subjects (n=2374) and non-control subjects (n=695) with early and late mild cognitive impairment (EMCI, LMCI), Alzheimers disease (AD), Early psychosis and Schizophrenia, Bipolar disorder, and Attention deficit hyperactivity disorder. Three different normative modelling methods were evaluated while controlling for sex, intracranial volume, and site. Z-scores and extreme z-score deviations were calculated and compared across phenotypes. GAMLSS models performed the best. Statistically significant shifts in z-score distributions consistent with atrophy were observed for most phenotypes. Shifts of progressively increasing magnitude were observed bilaterally from EMCI to AD with larger shifts in the left thalamic regions. Heterogeneous shifts were observed in psychiatric diagnoses with a predilection for the right thalamic regions. Here we present the first normative models of thalamic nuclear volumes and highlight their utility in evaluating heterogenous disorders such as Schizophrenia.

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Section: Discussionsupporting

confidence: 91%

Normative modeling of thalamic nuclear volumes

Young,

Kumar,

Saranathan

2024

Preprint

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“…Additionally, significant activation of the cingulate gyrus was observed during auditory hallucinations (Silbersweig et al, 1995). Recent studies had also indicated a significant correlation between the thalamus and temporal lobe and hallucinations and delusions (Ferri et al, 2018;Kaur et al, 2020;Perez-Rando et al, 2022). Thalamic dysregulation in connectivity may have represented a core neurobiological feature of SZ, underpinning positive symptoms (Ferri et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia

Zhao,

Jiang,

Bustillo

et al. 2024

Human Brain Mapping

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Schizophrenia (SZ) is a debilitating mental illness characterized by adolescence or early adulthood onset of psychosis, positive and negative symptoms, as well as cognitive impairments. Despite a plethora of studies leveraging functional connectivity (FC) from functional magnetic resonance imaging (fMRI) to predict symptoms and cognitive impairments of SZ, the findings have exhibited great heterogeneity. We aimed to identify congruous and replicable connectivity patterns capable of predicting positive and negative symptoms as well as cognitive impairments in SZ. Predictable functional connections (FCs) were identified by employing an individualized prediction model, whose replicability was further evaluated across three independent cohorts (BSNIP, SZ = 174; COBRE, SZ = 100; FBIRN, SZ = 161). Across cohorts, we observed that altered FCs in frontal‐temporal‐cingulate‐thalamic network were replicable in prediction of positive symptoms, while sensorimotor network was predictive of negative symptoms. Temporal‐parahippocampal network was consistently identified to be associated with reduced cognitive function. These replicable 23 FCs effectively distinguished SZ from healthy controls (HC) across three cohorts (82.7%, 90.2%, and 86.1%). Furthermore, models built using these replicable FCs showed comparable accuracies to those built using the whole‐brain features in predicting symptoms/cognition of SZ across the three cohorts (r = .17–.33, p < .05). Overall, our findings provide new insights into the neural underpinnings of SZ symptoms/cognition and offer potential targets for further research and possible clinical interventions.

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“…Among the thalamus parts that showed differences in patients with MDD, the medial and pulvinar have been the regions of interest because of their significant interconnection with the prefrontal cortex and other subcortical structures. The results of the study of many neuropsychiatric disorders reported changes in these regions of the thalamus, particularly in obsessive-compulsive disorder (OCD) ( 39 , 40 ), psychosis ( 41 ), schizophrenia ( 42 , 43 ), and Parkinson’s disease ( 44 ). As for depression, few studies have investigated the structural ( 19 ) and functional ( 45 ) alterations of medial and pulvinar regions in MDD patients.…”

Section: Discussionmentioning

confidence: 99%

Volumetric assessment of individual thalamic nuclei in patients with drug-naïve, first-episode major depressive disorder

et al. 2023

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IntroductionDespite the previous inconsistent findings of structural and functional abnormalities of the thalamus in patients with major depressive disorder (MDD), the disruption of the thalamic nuclei in the pathophysiology of this disorder has not yet been adequately studied. Therefore, we investigated the volumetric changes of thalamic subregions and their nuclei in drug-naïve, first-episode MDD patients. We also investigated the association between HAM-D scores, a clinical scale frequently used to evaluate the severity of depression and thalamic nuclei volumes in MDD patients.MethodsThis study included 76 drug-naïve MDD patients and an equal number of healthy subjects. Magnetic resonance imaging (MRI) data were obtained using a 3T MR system and thalamic nuclei volumes were evaluated using FreeSurfer ver.7.11. The volumetric differences were compared by one-way analysis of covariance (ANCOVA) and to ensure that effects were not accounted for by other factors, age, sex, and ETICV variables were included as covariates.ResultsWe observed significant volume reductions of the left whole thalamus (p < 0.003) and several thalamic nuclei mostly on the left side in the MDD group compared with healthy controls (HCs). Furthermore, we have revealed weak negative correlations between several thalamic nuclei volumes and HAM-D total and subscale scores.DiscussionThis is the first research study to investigate alterations of the various thalamic nuclei volumes in MDD patients compared with HCs. Moreover, we first analyzed the association between individual thalamic nuclei volumes and HAM-D subscale scores. Though our study may be restricted at certain levels, especially by the demographic difference between the two groups, they possibly contribute at a preliminary level to understanding the thalamic structural changes at its subregions in patients with drug-naïve, first-episode MDD.

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Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations

Cited by 20 publications

References 79 publications

Normative modeling of thalamic nuclear volumes

Normative modeling of thalamic nuclear volumes

Cross‐cohort replicable resting‐state functional connectivity in predicting symptoms and cognition of schizophrenia

Volumetric assessment of individual thalamic nuclei in patients with drug-naïve, first-episode major depressive disorder

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