Alterations in the Uterine Environment Produced by Iuds

Wrenn, T.R.; Wood, Joan R.; Bitman, Joel

doi:10.1530/jrf.0.0190511

Cited by 11 publications

(5 citation statements)

References 16 publications

(19 reference statements)

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“…In the rat uterus, the concentration of the monoamine decreases rather than increases around the time of implantation (Wrenn, Wood, and Bitman 1969). Cooper, Hawk, and Scommegna (1970) showed that the histamine concentration of the stroma and caruncles of the sheep uterus increases after ovariectomy but does not change appreciably throughout the oestrous cycle.…”

Section: (E) Phosphatases In the Garuncles During Early Pregnancymentioning

confidence: 99%

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Murdoch¹

1972

Aust. Jnl. Of Bio. Sci.

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An attempt was made to assess whether histamine is involved in the regulation of sheep uterine endometrial acid and alkaline phosphatases during early pregnancy. Interacting effects of progesterone and oestradiol on the endometrial enzymes and the behaviour of the phosphatases in the caruncles during early pregnancy were also examined.Histamine occurred in greater concentration in .the intercotyledonary endometrium than in the caruncles during early pregnancy and increased in both tissues between days 14 and 22. The concentration of the monoamine fell on day 31 of pregnancy and only low levels in the tissues were recorded on day 44. The subcutaneous administration of the potent histamine-releasing agent, compound 48/80, or the injection of histamine directly into the uterine lumen of ovariectomized ewes treated with combinations of progesterone and oestradiol benzoate, did not significantly alter the phosphatase activity of the endometrial tissue.Progesterone stimulated the acid and alkaline phosphatases in the intercotyledonary endometrium and maintained their activities at high levels for 21 days when administered at a dose rate of 10 mg/day. Oestradiol benzoate slightly decreased endometrial phosphatase activities when injected into ovariectomized ewes and limited the response of the enzymes to progesterone.. r Alkaline phosphatase activity in the caruncles increased between days 0 and 8 of pregnancy and fell on day 14. Only low levels of activity were found in the caruncles on days 22, 31, and 44 of pregnancy. Acid phosphatase maintained a constant level of activity in the caruncles throughout early pregnancy and was not influenced by the increase in histamine concentration between days 14 and 22.The results suggest the participation of factors other than histamine in the regulation of endometrial phosphatases during early pregnancy in the ewe. Progesterone and oestradiol may be involved to some extent but are not solely responsible for the control of the enzymes.

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Section: (E) Phosphatases In the Garuncles During Early Pregnancymentioning

confidence: 99%

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Murdoch¹

1972

Aust. Jnl. Of Bio. Sci.

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“…An "inert" IUD had no influence on the RNA or DNA content in the uterus of the Rhesus monkey (18). During early pregnancy in'the rat, an intra-uterine silk suture had no effect on the content of RNA and DNA (20), whereas a nylon IUD significantly increased the amount of these constituents (29). The DNAcontent in the uterus was lowered in the presence of a silk suture in ovariectomized, estrogen and progesterone treated rats (16).…”

mentioning

confidence: 99%

The Effect of a Copper IUD and “Inert” IUDS on the Incorporation of ³H‐Thymidine and 5‐³H‐Uridine Into the Endometrium of the Rabbit After Stimulation with Human Chorionic Gonadotropin

Grundsell

Håkansson

1975

Acta Obstet Gynecol Scand

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The present investigation studied the influence of different types of intra-uterine devices (IUDs) especially that of a copper IUD, on the incorporation of 3-H-thymidine and 5-3-H-uridine into the endometrium of the rabbit. "Inert" IUD. In non-stimulated rabbits, the incorporation of 3-H-thymidine was increased in the copper influenced horn. The incorporation of 3H-thymidine in control and Cu-IUD-containing horns reached a maximum at 48 hours after HCG stimulation, but was significantly lower in the copper-containing horn than in the control horn. On the fifth day of pseudopregnancy, the incorporation of 3-H-thymidine was significantly higher in the copper IUD-containing horn. The total amount of DNA in the endometrium increased during early pseudopregnancy, but this increase was markedly reduced in the presence of copper. The copper IUD had no influence on the rate of incorporation of 5-3-H-uridine in non-stimulated rabbits, whereas it caused a higher incorporation on the fifth day of pseudopregnancy.

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“…As mentioned above, the metabolism of FDP can be related to glycogen levels. Parr (1966) demonstrated histochemically that glycogen accumulated in the epithelium of an IUDcontaining horn, and a nylon IUD has been shown biochemically to produce increases in uterine weight, water, glycogen and nucleic acids (Wrenn, Wood & Bitman, 1969). The increased hydrolysis of FDP which we have demonstrated would facilitate this increase in uterine glycogen.…”

Section: Discussionmentioning

confidence: 50%

Fructose metabolism in the rat endometrium under normal and experimental conditions

Boshier¹,

Katz²

1976

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Summary. Fructose-1,6-diphosphate (FDP) hydrolysis, which was measured in tissue extracts from mature rat endometrium, was maximal during late dioestrus and early pro-oestrus and reflected the variations in the plasma levels of ovarian steroids. Treatment of ovariectomized animals with oestradiol or medroxyprogesterone acetate increased FDP hydrolysis when compared with control animals, although oestradiol was the more effective. FDP hydrolysis was greater in extracts of endometrial tissue from uterine horns containing a silk IUD or of deciduomal tissue from pseudopregnant rats, in which the peak was on Day 9, than in extracts of endometrium from the control contralateral horn. These findings are interpreted as linking glycogen metabolism in normal endometrium, IUD-containing horns, and decidual tissue to the role of FDP in gluconeogenesis and the promotion of glycogen storage.

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Alterations in the Uterine Environment Produced by Iuds

Cited by 11 publications

References 16 publications

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

The Effect of a Copper IUD and “Inert” IUDS on the Incorporation of ³H‐Thymidine and 5‐³H‐Uridine Into the Endometrium of the Rabbit After Stimulation with Human Chorionic Gonadotropin

Fructose metabolism in the rat endometrium under normal and experimental conditions

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Alterations in the Uterine Environment Produced by Iuds

Cited by 11 publications

References 16 publications

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

Phosphomonoesterases and Histamine in the Uterus of the Ewe During Early Pregnancy

The Effect of a Copper IUD and “Inert” IUDS on the Incorporation of 3H‐Thymidine and 5‐3H‐Uridine Into the Endometrium of the Rabbit After Stimulation with Human Chorionic Gonadotropin

Fructose metabolism in the rat endometrium under normal and experimental conditions

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The Effect of a Copper IUD and “Inert” IUDS on the Incorporation of ³H‐Thymidine and 5‐³H‐Uridine Into the Endometrium of the Rabbit After Stimulation with Human Chorionic Gonadotropin