2023
DOI: 10.1111/andr.13566
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Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction

Alexis N. Roach,
Sanat S. Bhadsavle,
Samantha L. Higgins
et al.

Abstract: BackgroundChronic preconception paternal alcohol use adversely modifies the sperm epigenome, inducing fetoplacental and craniofacial growth defects in the offspring of exposed males. A crucial outstanding question in the field of paternal epigenetic inheritance concerns the resilience of the male germline and its capacity to recover and correct sperm‐inherited epigenetic errors after stressor withdrawal.ObjectivesWe set out to determine if measures of the sperm‐inherited epigenetic program revert to match the … Show more

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