Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study

Zhang, Xueyan; Wang, Wei; Bai, Xiaoyan; Mei, Yanliang; Tang, Hefei; Yuan, Ziyu; Zhang, Xue; Li, Zhiye; Zhang, Peng; Hu, Zhangxuan; Zhang, Yaqing; Yu, Xueying; Sui, Binbin; Wang, Yonggang

doi:10.1186/s10194-023-01543-y

Cited by 15 publications

(12 citation statements)

References 56 publications

(55 reference statements)

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“…Some studies suggested that migraine with visual aura exist in altered neurochemical coupling in the occipital cortex [ 19 ]. Our recent study also reported decreased cerebral perfusion, increased regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in the middle occipital gyrus in patients with NDPH [ 8 , 27 ]. The above evidence suggests that the abnormal functional network and imbalance of neurotransmitters of the occipital lobe might be involved in headache and pain.…”

Section: Discussionmentioning

confidence: 95%

Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study

et al. 2023

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Background and purpose The pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional connectivity (FC) in patients with NDPH using resting-state functional magnetic resonance imaging (MRI). Methods Brain structural and functional MRI data were acquired from 29 patients with NDPH and 37 well-matched healthy controls (HCs) in this cross-sectional study. Region of interest (ROI) based analysis was used to compare FC between patients and HCs, with 116 brain regions in the automated anatomical labeling (AAL) atlas were defined as seeds. The correlations between aberrant FC and patients’ clinical characteristics, and neuropsychological evaluation were also investigated. Results Compared with HCs, patients with NDPH showed increased FC in the left inferior occipital gyrus, right thalamus and decreased FC in right lingual gyrus, left superior occipital gyrus, right middle occipital gyrus, left inferior occipital gyrus, right inferior occipital gyrus, right fusiform gyrus, left postcentral gyrus, right postcentral gyrus, right thalamus and right superior temporal gyrus. There were no correlation between FC of these brain regions and clinical characteristics, neuropsychological evaluation after Bonferroni correction (p > 0.05/266). Conclusions Patients with NDPH showed aberrant FC in multiple brain regions involved in perception and regulation of emotion and pain. Trial registration ClinicalTrials.gov Identifier: NCT05334927.

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Section: Discussionmentioning

confidence: 95%

Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study

et al. 2023

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“…We found that 39.28% of NDPH group had photophobia symptoms and their GM volume of calcarine increased. The brain perfusion of occipital in patients with NDPH was altered in our previous study, and we suggested that patients with NDPH may have abnormal activation of the visual system [ 39 , 40 ]. This is not surprising given the visual pathway's established role in nociceptive pathways.…”

Section: Discussionmentioning

confidence: 97%

Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI

et al. 2023

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Background New daily persistent headache (NDPH) is a rare but debilitating primary headache disorder that poses a significant burden on individuals and society. Despite its clinical importance, the underlying pathophysiological mechanisms of NDPH remain unclear. In this study, we aimed to investigate the brain structural changes and neural activity patterns in patients with NDPH using multimodal brain imaging analysis of structural magnetic resonance imaging (sMRI) combined with magnetoencephalography (MEG). Methods Twenty-eight patients with NDPH and 37 healthy controls (HCs) were recruited for this study, and their structural and resting-state data were collected by 3.0 Tesla MRI and MEG. We analyzed the brain morphology using voxel-based morphometry and source-based morphometry. In each brain region, MEG sensor signals from 1 to 200 Hz were analyzed using an adapted version of Welch's method. MEG source localization was conducted using the dynamic statistical parametric mapping, and the difference of source distribution between patients with NDPH and HCs was examined. Results Our results revealed significant differences in the regional grey matter volume, cortical thickness, and cortical surface area between the two groups. Specifically, compared with HCs, patients with NDPH showed a significant decrease in cortical thickness of the left rostral cortex in the middle frontal gyrus, decreased cortical surface area of the left fusiform gyrus, decreased grey matter volume of the left superior frontal gyrus and the left middle frontal gyrus, and increased grey matter volume of the left calcarine. Furthermore, the power of the whole brain, bilateral frontal lobes, and right temporal lobe in the NDPH group were higher than that in HCs in the ripple frequency band (80-200 Hz). Functional and structural analysis suggested that there were structural changes and abnormal high frequency cortical activity in both frontal and temporal lobes in patients with NDPH. Conclusion Our findings indicated that patients with NDPH have abnormalities in brain morphology, such as cortical area, cortical thickness, and grey matter volume, accompanied by abnormal cortical neural activity. Brain structural changes in the frontotemporal cortex and abnormalities in cortical ripple activity may be involved in the pathogenesis of NDPH.

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“…The sample size was based on the available data and previous literature. 10 We described normally distributed data as mean ± SD and non-normally distributed data as median with interquartile range. The chi-square test allowed comparison of gender between patients and HCs.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…6 Our previous studies showed that adult patients with NDPH have unique alterations in hemodynamics, regional homogeneity, multiple frequency amplitudes of low-frequency fluctuation, cortical activity, and brain functional connectivity (FC) in certain brain regions. [7][8][9][10] FC is defined as the temporal coincidence of spatially distant neurophysiological events. Over the last decade, an increasing number of studies have applied magnetic resonance imaging (MRI) to explore FC in headache disorders.…”

Section: Introductionmentioning

confidence: 99%

Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting‐state functional magnetic resonance imaging

Wang,

Qiu,

Mei

et al. 2024

CNS Neurosci Ther

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ObjectivesThe new daily persistent headache (NDPH) is a rare primary headache disorder. However, the underlying mechanisms of NDPH remain incompletely understood. This study aims to apply seed‐based analysis to explore the functional connectivity (FC) of brainstem nuclei in patients with NDPH using resting‐state functional magnetic resonance imaging (MRI).MethodsThe FC analysis from the region of interest (ROI) to whole brain voxels was used to investigate 29 patients with NDPH and 37 well‐matched healthy controls (HCs) with 3.0 Tesla MRI. The 76 nuclei in the brainstem atlas were defined as ROIs. Furthermore, we explored the correlations between FC and patients' clinical characteristics and neuropsychological evaluations.ResultsPatients with NDPH exhibited reduced FC in multiple brainstem nuclei compared to HCs (including right inferior medullary reticular formation, right mesencephalic reticular formation, bilateral locus coeruleus, bilateral laterodorsal tegmental nucleus‐central gray of the rhombencephalon, median raphe, left medial parabrachial nucleus, periaqueductal gray, and bilateral ventral tegmental area‐parabrachial pigmented nucleus complex) and increased FC in periaqueductal gray. No significant correlations were found between the FC of these brain regions and clinical characteristics or neuropsychological evaluations after Bonferroni correction (p > 0.00016).ConclusionsOur results demonstrated that patients with NDPH have abnormal FC of brainstem nuclei involved in the perception and regulation of pain and emotions.

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Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study

Cited by 15 publications

References 56 publications

Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study

Mapping the aberrant brain functional connectivity in new daily persistent headache: a resting-state functional magnetic resonance imaging study

Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI

Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting‐state functional magnetic resonance imaging

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