Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure

Garcés, Mariana; Magnani, Natalia; Pecorelli, Alessandra; Calabró, Valeria; Marchini, Timoteo; Cáceres, Lourdes; Pambianchi, Erika; Galdopórpora, Juan Manuel; Vico, Tamara; Salgueiro, Jimena; Zubillaga, Marcela; Morettón, Marcela A.; Desimone, Martín Federico; Álvarez, Silvia; Valacchi, Giuseppe; Evelson, Pablo

doi:10.1016/j.freeradbiomed.2021.02.008

Cited by 20 publications

(15 citation statements)

References 74 publications

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“…In order to reduce cytotoxicity of the antimicrobial scaffolds based on collagen and silver nanoparticles, a Cannabis sativa oil was added to the hydrogels. It was demonstrated that AgNPs stimulate the production of reactive O 2 species inducing oxidative stress in cells and thus inhibiting their proliferation [ 46 ]. In this sense, as Cannabis sativa has shown remarkable antioxidant capacity [ 47 ] stimulating wound healing, we added this natural extract to Col-AgNPs.…”

Section: Resultsmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.

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Section: Resultsmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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“…Tight junction proteins in the lung epithelium are a known target of oxidative stress damage, which alters epithelial transport processes and damages the homeostasis and integrity of the lung epithelial barrier. 30 …”

Section: Toxicity Of Nano Silver To Organsmentioning

confidence: 99%

“… 38 As shown in Table 2 , the following mainly describes the cytotoxicity of silver nanoparticles based on the progressive effect induced on cell layers. 24 , 30–32 , 36 Figure 2 shows the potential mechanisms of nano silver-induced cytotoxicity in the cell.…”

Section: Toxicity Of Nano Silver To Cellsmentioning

confidence: 99%

Nano Silver-Induced Toxicity and Associated Mechanisms

Zhang¹,

Wang²,

Yalamarty³

et al. 2022

IJN

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Nano silver is one of the most widely used engineering nanomaterials with antimicrobial activity against bacteria, fungi, and viruses. However, the widespread application of nano silver preparations in daily life raises concerns about public health. Although several review articles have described the toxicity of nano silver to specific major organs, an updated comprehensive review that clearly and systematically outlines the harmful effects of nano silver is lacking. This review begins with the routes of exposure to nano silver and its distribution in vivo. The toxic reactions are then discussed on three levels, from the organ to the cellular and subcellular levels. This review also provides new insights on adjusting the toxicity of nano silver by changing their size and surface functionalization and their combination with other materials to form a composite formulation. Finally, future development, challenges, and research directions are discussed.

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“…111,112 A few NPs, like Ag-NPs, can trigger both. 113 Although it has been shown that high ROS affects TJ protein expression and localization and causes cytoskeleton reorganization, ROS from different sources may control distinct downstream molecules. 114−116 NOX-derived ROS, for instance, regulated actin filaments, whereas mitochondria-derived ROS regulated microtubules, resulting in distinct consequences of opening the paracellular barrier.…”

Section: Reactive Oxygen Species-based Mechanismmentioning

confidence: 99%

How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects

Zhu

Liu

et al. 2022

ACS Nano

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Biological barriers are essential physiological protective systems and obstacles to drug delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either causing adverse health impacts on humans or producing therapeutic opportunities. This Review introduces the structural and functional influences of NPs on the key components that govern the paracellular route, mainly tight junctions, adherens junctions, and cytoskeletons. Furthermore, we evaluate their interaction mechanisms and address the influencing factors that determine the ability of NPs to open the paracellular route, which provides a better knowledge of how NPs can open the paracellular route in a safer and more controllable way. Finally, we summarize limitations in the research models and methodologies of the existing research in the field and provide future research direction. This Review demonstrates the in-depth causes for the reversible opening or destruction of the integrity of barriers generated by NPs; more importantly, it contributes insights into the design of NP-based medications to boost paracellular drug delivery efficiency.

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Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure

Cited by 20 publications

References 74 publications

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Nano Silver-Induced Toxicity and Associated Mechanisms

How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects

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