Alterations in lung compliance and functional residual capacity with posture

Lim, Thomas P. K.; Luft, Ulrich C.

doi:10.1152/jappl.1959.14.2.164

Cited by 48 publications

(21 citation statements)

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“…Since DD does not affect the elastic recoil in normals [15,21,22], one may infer that AO reflects airway obstruc tion rather than a decrease in elastic recoil. The airway ob struction in AO of DD may recognize four mechanisms acting separately or together: bronchospasm, intrabronchial accumulation of secretions, wave-speed flow-limita tion or dynamic compression.…”

Section: Discussionmentioning

confidence: 98%

“…A recent article failed to substantiate the specificity of this late decrease in FEVj or FVC during DD [20]; notably, the presence of wheezing was not assessed in either study [15,20], Unlike the late decrease in spirographic tests in [20], in the pre sent article these changes appear to be DD-related since they return to S| level when S2 is assumed. In normal [12,17,, asthmatic [1] or bronchitic [24] subjects a short period of time spent in DD was not accom panied by changes in FEV, [1,17,24[, flow volume loop en velope [12], pulmonary resistance [21], specific airway compliance [22] or ratio of dynamic compliance/static compliance [23] suggestive of airway obstruction.…”

Section: Discussionmentioning

confidence: 99%

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Wheezing Triggered by Dorsal Decubitus: Pulmonary Function Changes

Popa

Zumstein²

1993

Respiration

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In 23 subjects with chronic obstructive pulmonary disease (COPD) who wheezed when changing their position from sitting to dorsal decubitus (DD), we recorded lung volumes and flow volume loops in sitting (S₁), DD and immediately after resuming sitting (S₂). We found three main patterns of ventilatory changes associated with wheezing in DD: (1) acute obstruction (AO) in 14 subjects characterized by FEV₁≥-10% and % FEV₁/FVC≥-3%; functional residual capacity or residual volume was increased, decreased or unchanged; (2) acute restriction (AR) in 7 subjects characterized by absence of obstruction spirographically and FVC and/or FRC > -10%; (3) indeterminate response (IR) in 2 subjects. Except for 3 subjects, the changes recorded in DD returned to baseline in S₂. Both AO and AR responses in DD and their rapid resolution in S₂ were reproducible (11 subjects). In conclusion: (1) in COPD, DD may trigger wheezing; (2) the physiologic changes during DD wheezing are reproducible, rapidly reversible when the sitting position is resumed and unlike those recorded during bronchoprovocation, heterogeneous.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Wheezing Triggered by Dorsal Decubitus: Pulmonary Function Changes

Popa

Zumstein²

1993

Respiration

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“…The method used to support the anesthetized dogs illustrated in FIGURE 10 may have caused part of the abdominal contents to move into the chest cavity, reducing the lung volume. Although information directly applicable to this situation could not be obtained, Lim and Luft (1959) measured functional residual capacities of human subjects in the supine position that were 65 -70 percent of those measured when the subjects were standing erect.…”

Section: Missile Time-displacement Studymentioning

confidence: 99%

Biophysical Mechanisms and Scaling Procedures Applicable in Assessing Responses of the Thorax Energized by Air-Blast Overpressures or by Nonpenetrating Missiles

Bowen¹,

Fletcher²,

Richmond³

et al. 1966

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FOREWORDThis report contains the results of efforts to understand some of the biophysical mechanisms involved in the response of mammals to air-blast overpressures and to impact of non-penetrating missiles on the chest wall. One of the important aims of these studies is a more complete understanding of the response data obtained with mammals so that reasonable predictions can be made for the response of man.The empirical data and interpretative material included in this report represent a portion of the results of an ongoing, long-term program aimed at clarifying the biological effects of blast-induced phenomena and assessing the consequences of exposure thereto.This report was summarized on October 6, 1966, before a symposium on the Biological Effects of Air Blast at the National Academy of Sciences sponsored by the NAS-NRC Committee on Hearing, Bioacoustics, and Biomechanics, "CHABA".On October 11, 1966, that portion of the report concerned with the effects of air-blast overpressures was presented at the New York Academy of Sciences conference on Prevention of and Protection against Accidental Explosion of Munitions, Fuels, and other Hazardous Mixtures. The entire report was submitted for inclusion in the Annals of the New York Academy of Sciences. ABSTRACT A mathematical model was described which was devised to study the dynamic response of the thorax of mammals to rapid changes in environmental pressure and to non-penetrating missiles impacting the rib cage near the mid-lateral point of the right or left thorax. Scaling procedures f 'imiiar animals were described relating, for a given degree of darn'age, the body mass of the animal to various parameters describing the exposure "dose.Internal pressures computed with the model for a dog exposed at the end plate of a shock-tube were compared to those measured with a pressure transducer inserted in the esophagus down to the level -of the heart.Computed time-displacement histories of missiles following impact with the right side of the thorax were compared to those obtained experimentally by means of high-speed motion picture photography. High internal pressures predicted with the model for non-penetrating impact were compared to those obtained experimentally and theoretically for exposure to air blast.Experimental data were presented arbitrarily assessing lung damage in animals struck by non-penetrating missiles (constant impact area) as a function of missile mass and impact velocity. These data were compared for several missile mass-velocity combinations with those computed using the mathematical model. Similarities in the dynamic responses of the thorax to air blast and to non-penetrating missiles were discussed.ii ACKNOWLEDGMENTS

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“…spezifischen Compliance (Lim und Luft [10]) wurde versucht, den schon u n ter physiologischen Verhältnissen wirksamen Einfluß der K apazität au f die statische D ehnbarkeit (Cook und M itarbeiter [3]) zu eliminie ren und eine Annäherung an die spezifische Dehnbarkeit des Gewebes selbst zu gewinnen. Angesichts der oben diskutierten Problem atik schien dieser Borochuungsmodtis gerechtfertigt.…”

Section: Ergebnisseunclassified

Untersuchungen der Atemmechanik bei Silikose unter besonderer Berücksichtigung des obstruktiven Syndroms

Zeilhofer¹,

Rupprecht²

1963

Respiration

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Alterations in lung compliance and functional residual capacity with posture

Cited by 48 publications

References 0 publications

Wheezing Triggered by Dorsal Decubitus: Pulmonary Function Changes

Wheezing Triggered by Dorsal Decubitus: Pulmonary Function Changes

Biophysical Mechanisms and Scaling Procedures Applicable in Assessing Responses of the Thorax Energized by Air-Blast Overpressures or by Nonpenetrating Missiles

Untersuchungen der Atemmechanik bei Silikose unter besonderer Berücksichtigung des obstruktiven Syndroms

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