Alterations in Human Skeletal Muscle Lipid Composition and Metabolism Induced by Physical Conditioning1

Morgan, TE; Short, F. A.; Cobb, L. A.

doi:10.1159/000387225

Cited by 4 publications

(4 citation statements)

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“…A further support is the finding of increased concentration of phospholipids and cholesterol in the muscle tissue after training. As recently suggested by Morgan et al [28] this increase can be taken as an indication of hyperplasia or hypertrophy of membranes in the muscle tissue caused by the training. The strongest, although indirect, evidence that the change in metabolic activity in muscle tissue is an important contributive factor for the improvement of the symptoms in patients with intermittent claudication is the sigmfic@ correlation between the increase in metabolic activity and the increase in walking tolerance after physical training in the individual cases (Fig.…”

Section: Discussionmentioning

confidence: 71%

Metabolic Activity of Skeletal Muscle in Patients with Peripheral Arterial Insufficiency

Dahllöf

Björntorp

Holm

et al. 1974

Eur J Clin Investigation

133

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18 patients with intermittent claudication were studied to find some explanation for the beneficial effect of physical training on their symptoms. The patients were randomly allocated to a training group and a placebo-treated control group. The effect of treatment on serum lipids, muscle lipids and glycogen, walking tolerance, calf blood flow, muscle succinic oxidase activity and the in vitro incorporation rate of glucose-carbon into various metabolites were studied.In the control group none of theseparametem were changed.In the trained group the following significant changes were found: Walking tolerance improved; muscle contents of cholesterol and phospholipids increased, as did succinic o x i d e activity and the incorporation rate of glucosekarbon into glycogen. lipids and carbon dioxide. Incorporation of glucosecarbon into lactate decreased.The improvement in walking tolerance was correlated with the altered pattern of metabolic activity but was not associated with increased calf blood flow. It is concluded that metabolic changes in skeletal muscles may be important in explaining the beneficial effects of physical training in patients with peripheral arterial insufficiency.Key worde: Arterial insufficiency, walking tolerance, physical training, muscle blood flow, succinic oxidase activity in skeletal muscle, glucose metabolism, skeletal miiscle, lipids, skeletal muscle, skeletal miiscle, human.

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Section: Discussionmentioning

confidence: 71%

Metabolic Activity of Skeletal Muscle in Patients with Peripheral Arterial Insufficiency

Dahllöf

Björntorp

Holm

et al. 1974

Eur J Clin Investigation

133

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“…Bellman and Zetterquist [19] showed that the femoral venous oxygen saturation decreased to very low values during exercise, mean 9.5% as compared to 2596 in the normal controls. As suggested by Morgan et al [22] such an increase might be evidence that the number of mitochondria is increased. This phenomenon has been explained by a redistribution of the blood flow, i. e. the available leg blood flow is directed to a greater extent to the exercising muscles a t the expense of other tissues [20,21].…”

Section: Discussionmentioning

confidence: 72%

“…The diseased gastrocnemius muscle tissue revealed an increased concentration of phospholipids. As suggested by Morgan et al [22] such an increase might be evidence that the number of mitochondria is increased. The sigdicantly higher activity of succinic oxidase in gastrocnemius muscle tissue from claudication patients gives strong support to this suggestion.…”

Section: Discussionmentioning

confidence: 72%

Metabolic Activity in Human Skeletal Muscle Effect of Peripheral Arterial Insufficiency

Holm

Björntorp

Scherstén

1972

Eur J Clin Investigation

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Succinic oxidase activity and the incorporation rates of glucose-carbon into glycogen, lipids, lactate and carbon-dioxide were studied in vitro in samples of skeletal muscle taken from patients with peripheral arterial insufficiency.In the patients with intermittent claudication significantly increased succinic oridase activity and incorporation rates of glucose-carbon were found in muscle tissue taken from the medial head of the gastrocnemius muscle. In patients with evidence of ischaemia a t rest the metabolic activity in the muscle tissue was similar to the controls but significantly lower than in the patients with claudication on all points. K e y words: Succinic oxidase activity, skeletal muscle; [U-l%] glucose; glucose metabolism, skeletal muscle; glycogen synthesis, muscle; lipid synthesis, muscle; arterial insufficiency; skeletal muscle, human. J. Holm et al. : Muscle Metabolism in Peripheral Arterial Insufficiency Europ. J . din. Invest. 10 % 7% 65 %

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“…The activity of lipoprotein lipase has been shown to increase in muscle with prolonged exercise (Borensztajn et al, 1975;Nikkila et al, 1978;Lithell et al, 1981). The third source of fatty acids is the fat stored within the tissue itself, which has been shown to be quantitatively greater in physically trained subjects than in untrained subjects (Morgan et al, 1969;Froberg, 1971;Reitman et al, 1973;Stankiewicz-Choroszocha & Gorski, 1978).…”

mentioning

confidence: 99%

Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats

Barakat¹,

Kasperek²,

Dohm³

et al. 1982

Biochemical Journal

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The influence of exhaustive exercise on the capacity of liver and muscle of rats to oxidize fatty acids was investigated in vitro. The rate of oxidation of fatty acids by liver preparations was significantly elevated as a result of exhaustion. Concurrently, the concentrations of beta-hydroxybutyrate were elevated in the plasma of the exhausted rats, suggesting that oxidation of fatty acids was also elevated in vivo. These findings are analogous to the findings of increased oxidation of fatty acids that results from training. In muscle, oxidation of palmitate, palmitoylcarnitine and beta-hydroxybutyrate by homogenates and isolated mitochondria was depressed with exercise. Despite the decrease in the oxidative capacity of the muscle preparations, the activities of several enzymes of beta-oxidation were either increased or unchanged as a result of exercise, suggesting that the depression in fatty acid oxidation may not be related to alterations in the process of beta-oxidation. Further studies showed that oxidation of [2-(14)C]pyruvate by muscle was depressed, whereas oxidation of [1-(14)C]pyruvate was not changed as a result of exercise. These results suggest that the decrease in fatty acid oxidation may be related to aberrations in the oxidation of acetyl-CoA. The changes in fatty acid oxidation that were observed, which are at variance with what is reported to occur with training, may have resulted from increased fragility of muscle mitochondria as a result of exercise. This increased fragility may render the mitochondria more susceptible to experimental manipulations in vitro and a subsequent loss of normal function.

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Alterations in Human Skeletal Muscle Lipid Composition and Metabolism Induced by Physical Conditioning1

Cited by 4 publications

References 0 publications

Metabolic Activity of Skeletal Muscle in Patients with Peripheral Arterial Insufficiency

Metabolic Activity of Skeletal Muscle in Patients with Peripheral Arterial Insufficiency

Metabolic Activity in Human Skeletal Muscle Effect of Peripheral Arterial Insufficiency

Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats

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