Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid

Payan, Donald G.; Wong, Michael Y.; Chernov-Rogan, Tania; Valone, Frank H.; Pickett, Walter C.; Blake, Vincent A.; Gold, Warren M.; Goetzl, Edward J.

doi:10.1007/bf00915380

Cited by 148 publications

(67 citation statements)

References 24 publications

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“…Consuming fish oil results in partial replacement of AA in inflammatory cell membranes by EPA (Lee et al, 1985;Endres et al, 1989) and thus demonstrates a potentially beneficial anti-inflammatory effect of n-3 PUFA. Supplementing the diet with n-3 PUFA has been shown to reduce AA concentrations in neutrophils and neutrophil chemotaxis, reduce LT generation (Lee et al, 1985;Payan et al, 1986), and reduce airway late response to allergen exposure (Arm et al, 1989). These data are consistent with the proposed pathway by which dietary intake of n-3 PUFA modulates lung disease.…”

Section: Introductionsupporting

confidence: 70%

“…Okamoto et al (2000a, b) observed suppression of LTB 4 and LTC 4 generation by leukocytes and improvement in respiratory function following 4 weeks of perilla seed oil (n-3 PUFA)-rich supplementation in asthmatic subjects. Payan et al (1986) found that high doses, compared to low doses, of EPA ethyl ester taken daily for 8 weeks increased LTB 5 generation, and reduced AA, LTB 4 , and PGE 2 generation by polymorphonuclear (PMN) and mononuclear leukocytes in asthmatic patients. These authors did not report pulmonary function scores, medication use, or asthma symptom scores.…”

Section: Interventional Studiesmentioning

confidence: 99%

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Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

Mickleborough

Rundell

2005

Eur J Clin Nutr

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Section: Introductionsupporting

confidence: 70%

Section: Interventional Studiesmentioning

confidence: 99%

Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

Mickleborough

Rundell

2005

Eur J Clin Nutr

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“…We have previously wrestled with the issue of an ideal control fatty acid to compare with fish oil (5) and in this investigation, chose corn oil, having used olive oil in 2 previous studies (5,ll). It is not unlikely that there are some mono-or polyunsaturated fatty acids that have potentially significant immunologic effects (24)(25)(26)(27). We believe that the issue of the ideal placebo dietary intervention to compare with fish oil has not yet been settled.…”

Section: Discussionmentioning

confidence: 99%

Effects of high‐dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs clinical and immune correlates

Kremer

Lawrence

Petrillo

et al. 1995

Arthritis & Rheumatism

229

109

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Objective. To determine the following: 1) whether dietary supplementation with fish oil will allow the discontinuation of nonsteroidal antiinflammatory drugs (NSAIDs) in patients with rheumatoid arthritis (RA); 2) the clinical efficacy of high‐dose dietary ω3 fatty acid fish oil supplementation in RA patients; and 3) the effect of fish oil supplements on the production of multiple cytokines in this population.Methods. Sixty‐six RA patients entered a double‐blind, placebo‐controlled, prospective study of fish oil supplementation while taking diclofenac (75 mg twice a day). Patients took either 130 mg/kg/day of ω3 fatty acids or 9 capsules/day of corn oil. Placebo diclofenac was substituted at week 18 or 22, and fish oil supplements were continued for 8 weeks (to week 26 or 30). Serum levels of interleukin‐1β (IL‐1β), IL‐2, IL‐6, and IL‐8 and tumor necrosis factor α were measured by enzyme‐linked immunosorbent assay at baseline and during the study.Results. In the group taking fish oil, there were significant decreases from baseline in the mean (±SEM) number of tender joints (5.3 ± 0.835; P < 0.0001), duration of morning stiffness (−67.7 ± 23.3 minutes; P = 0.008), physician's and patient's evaluation of global arthritis activity (−0.33 ± 0.13; P = 0.017 and −0.38 ± 0.17; P = 0.036, respectively), and physician's evaluation of pain (−0.38 ± 0.12; P = 0.004). In patients taking corn oil, no clinical parameters improved from baseline. The decrease in the number of tender joints remained significant 8 weeks after discontinuing diclofenac in patients taking fish oil (−7.8 ± 2.6; P = 0.011) and the decrease in the number of tender joints at this time was significant compared with that in patients receiving corn oil (P = 0.043). IL‐1β decreased significantly from baseline through weeks 18 and 22 in patients consuming fish oil (−7.7 ± 3.1; P = 0.026).Conclusion. Patients taking dietary supplements of fish oil exhibit improvements in clinical parameters of disease activity from baseline, including the number of tender joints, and these improvements are associated with significant decreases in levels of IL‐1β from baseline. Some patients who take fish oil are able to discontinue NSAIDs without experiencing a disease flare.

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“…Also, a number of studies have been conducted investigating the possible therapeutic affects of fish oil on asthmatic adult patients. It has been reported that fish oil supplementation in patients with asthma has antiinflammatory effects [264][265][266] . Also, fish oil trials have shown beneficial effects on asthma clinical outcomes 267 .…”

Section: Immune System Disordersmentioning

confidence: 99%

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Kremmyda¹,

Tvrzická²,

Staňková³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

152

134

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Background. This is the second of two review parts aiming at describing the major physiological roles of fatty acids, as well as their applications in specific conditions related to human health.Results. The review included the current literature published in Pubmed up to March 2011. In humans, fatty acids are a principle energy substrate and structural components of cell membranes (phospholipids) and second messengers. Fatty acids are also ligands of nuclear receptors affecting gene expression. Longer-chain (LC) polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid are precursors of lipid mediators such as eicosanoids (prostaglandins, leukotrienes, thromboxanes), resolvins and neuroprotectins. Lipid mediators produced by EPA and DHA (LC n-3 PUFA; mainly found in oily fish) are considered as inflammation-resolving, and thus, fish oil has been characterised as antiinflammatory. Recommendations for EPA plus DHA intake from oily fish vary between 250-450 mg/day. Dietary reference values for fat vary between nutrition bodies, but mainly agree on a low total and saturated fat intake. The existing literature supports the protective effects of LC n-3 PUFA (as opposed to n-6 PUFA and saturated fat) in maternal and offspring health, cardiovascular health, insulin sensitivity, the metabolic syndrome, cancer, critically ill patients, and immune system disorders.Conclusion. Fatty acids are involved in multiple pathways and play a major role in health. Further investigation and a nutrigenomics approach to the effects of these biocompounds on health and disease development are imperative and highlight the importance of environmental modifications on disease outcome.humans. Thus, these FA may be characterised as conditionally essential depending on EFA availability. Genetic variation in human desaturase genes affects FA metabolism, plasma lipid profiles, and risk of disease development [5][6][7] . Recommendations for minimum dietary intake of EPA plus DHA vary between 250-450 mg/day 8 , especially for pregnant women and those of reproductive age. Rich sources of LC n-3 PUFA are fish oils and the flesh of oily fish, whereas non-oily (white) fish contain them but in lower amounts.Long-chain PUFA with 18-20 carbon atoms, including EPA and AA, are precursors of eicosanoids (prostaglandins, leucotrienes and thromboxanes), which have a broad scale of regulatory, autocrine and paracrine effects. Long-chain PUFA with 20 and 22 carbon atoms are precursors of autacoids -resolvins (resolution phase interaction products), lipoxins and neuroprotectins 9 . FA are also ligands of nuclear receptors which take part in the subcellular control of metabolic pathways. Covalent modification of proteins by FA acylation enables their incorporation into membranes. Hydroxy FA are activators of some nuclear factors and are responsible for the expression of proinflammatory cytokines (interleukin (IL)-1,

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Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid

Cited by 148 publications

References 24 publications

Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

Effects of high‐dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs clinical and immune correlates

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

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