Alterations in biomarkers of endothelial function following on‐pump coronary artery revascularization

Abstract

CPB is characterised by pronounced changes in plasma sP-s, sE-s, TN, vWF levels, and ACE activity, which are associated with significant alteration in the intra- and early postoperative endothelial function observed in open heart surgery.

Potential biomarkers for predicting outcomes in CABG cardiothoracic surgeries

“…vWF was shown to be a predictor of ischemic heart disease in healthy individuals and patients with angina or acute MI [53]. Certain intra-operative variables, such as the extent of the surgical procedure, duration of use of the bypass machine, and amount of ischemia from cross clamping, are reported to be higher in patients who developed post-operative MI [33].…”

“…Thus, the availability of useful biochemical markers for evaluating the endothelial state post-operatively offers a useful, non-invasive means to assess return of the endothelium to the unperturbed state, which is important in improving patient outcome [53]. Among the relevant markers, E and P selectins were found to be the most influential.…”

“…High levels of these selectins reflect platelet activation and induce procoagulation activity associated with vascular thrombotic disease. Plasma selectins have been shown to predict major cardiovascular events in patients with pre-existing PAD or CAD [53]. …”

“…Panagiotopoulous et al measured concentrations of E and P selectins, tetranectin, von Willebrand Factor, and angiotensin converting enzyme in patients undergoing CABG prior to and up to 3 days after their procedure [53]. These markers were compared with patient demographics and multiple perioperative characteristics [53]. Differences in levels among markers between patients correlated with the degree of pre-existing endothelial damage and atherosclerosis.…”

Cancer-related deaths among different treatment options in chronic coronary artery disease

“…In this clinical entity, strong evidence shows that there is a secondary state of immunosuppression. Therefore, this clinical [14][15][16][17][18].…”