Alterations by perfluorooctanoic acid of glycerolipid metabolism in rat liver

Effects of Perfluorooctanoic Acid on the Synthesis of Phospholipids in the Liver of Mice Fed a Dietary Soybean Oil, Perilla Oil or Fish Oil.

“…The effects of PFOA on hepatic contents of PtdCho, PTdEtn and PtdIns observed in mice were different from the findings derived from the experiments using rats where hepatic contents of these phospholipids were increased by PFOA treatment from 2.2 fold to 2.4 fold. 8) The increase in 18 : 1 and the decrease in 18 : 0 observed in the three phospholipid classes were thought to be due to an induction of stearoyl-CoA desaturase that catalyzes the conversion of 18 : 0 to 27 18 : 1. 3,7,8) It is of interest that the PFOA-induced decrease in polyunsaturated fatty acids was not significant in FO-fed mice compared to other dietary groups.…”

“…8) The increase in 18 : 1 and the decrease in 18 : 0 observed in the three phospholipid classes were thought to be due to an induction of stearoyl-CoA desaturase that catalyzes the conversion of 18 : 0 to 27 18 : 1. 3,7,8) It is of interest that the PFOA-induced decrease in polyunsaturated fatty acids was not significant in FO-fed mice compared to other dietary groups. This may be due to the fact that polyunsaturated fatty acids of n-3 series are preferentially utilized to form phospholipids, especially PtdEtn.…”

“…[1][2][3][4][5][6][7][8] The amounts of various phospholipids as well as triacylglycerol (TG) in the liver were greatly increased by the treatment of rats with PFOA. 2,5,8) In addition, fatty acid profile was greatly altered; octadecenoic acid (18 : 1) was increased whereas stearic acid (18 : 0) and arachidonic acid were decreased in phospholipids in rat liver. 3,7,8) Such changes are, at least in part, due to changes in the activities of lipid metabolizing enzymes in rat liver.…”

“…2,5,8) In addition, fatty acid profile was greatly altered; octadecenoic acid (18 : 1) was increased whereas stearic acid (18 : 0) and arachidonic acid were decreased in phospholipids in rat liver. 3,7,8) Such changes are, at least in part, due to changes in the activities of lipid metabolizing enzymes in rat liver. [6][7][8] Compared to rats, little information is available for mice about PFOA-induced changes in lipid metabolism.…”

“…3,7,8) Such changes are, at least in part, due to changes in the activities of lipid metabolizing enzymes in rat liver. [6][7][8] Compared to rats, little information is available for mice about PFOA-induced changes in lipid metabolism. In the previous study, we demonstrated that PFOA caused a significant accumulation of TG in mice fed a diet containing soybean oil (SO) or perilla oil (PO) but not in mice fed a fish oil (FO)-containing diet.…”