Perfluorooctanoic Acid and Cardiovascular Disease in US Adults

Abstract

Exposure to PFOA is associated with CVD and PAD, independent of traditional cardiovascular risk factors.

Involvement of NRF2 in Perfluorooctanoic Acid-Induced Testicular Damage in Male Mice1

“…It has been demonstrated that exposure to PFOA causes a variety of toxicities, including hepatotoxicity, carcinogenicity, neurotoxicity, immunotoxicity, and genotoxicity [24][25][26][27][28]. Epidemiologic studies have also shown that PFOA exposure is positively associated with cardiovascular disease [29], chronic kidney disease [30], thyroid disease [31], and hepatocellular damage [32]. In a recent study, PFOA content in the testes of mice exposed to PFOA 20 mg/kg/day for 28 days reached 8.06 μg/g, and the corresponding serum PFOA content was 105 μg/mL [33], which was similar to the highest serum PFOA levels reported in occupational workers [9].…”

Per- and polyfluorinated substances (PFASs): Environmental challenges

“…Another study found, however, a positive association with PFHxS [309]. PFOA and/or PFOS have been associated with serum uric acid [310,311], chronic kidney disease [312], abnormal liver enzyme increases, especially in obese individuals [313], cardiovascular disease [314] and thyroid disease [315]. Different PFAAs showed different, sex and ethnicity-dependent effects on thyroid [316].…”

Quercetin protects against perfluorooctanoic acid-induced liver injury by attenuating oxidative stress and inflammatory response in mice

“…Liver injury 20 The aim of the present study was to investigate the protective effect of quercetin (Que) against perfluorooctanoic 21 acid (PFOA)-induced liver injury in mice and its possible mechanisms of action. Mice were intragastrically 22 administered PFOA (10 mg/kg/day) alone or in combination with Que (75 mg/kg/day) for 14 consecutive days.…”