2004
DOI: 10.1016/j.pain.2004.07.014
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Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats

Abstract: After transection of the inferior alveolar nerve (IAN), the whisker pad area, which is innervated by the infraorbital nerve (ION) that was not injured, showed hypersensitivity to mechanical stimulation. Two days after IAN transection, threshold intensity for escape behavior to mechanical stimulation of the ipsilateral whisker pad area was less than 4.0 g, indicating mechanical allodynia. A total of 68 single fiber discharges were recorded from ION fibers at 3 days after IAN transection. The responses of C- and… Show more

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Cited by 107 publications
(90 citation statements)
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“…Consistent with our result, previous studies have demonstrated the abnormal pain in the territory of an uninjured nerve associated with peripheral nerve injury. 26,27 For example, the inferior alveolar nerve transection alone produced mechanical hypersensitivity in the whisker pad area, which was innervated by uninjured infraorbital nerve, a branch of the maxillary trigeminal nerve. 27 There could be several possible explanations for this phenomenon.…”
Section: Physiological Implicationmentioning
confidence: 99%
See 1 more Smart Citation
“…Consistent with our result, previous studies have demonstrated the abnormal pain in the territory of an uninjured nerve associated with peripheral nerve injury. 26,27 For example, the inferior alveolar nerve transection alone produced mechanical hypersensitivity in the whisker pad area, which was innervated by uninjured infraorbital nerve, a branch of the maxillary trigeminal nerve. 27 There could be several possible explanations for this phenomenon.…”
Section: Physiological Implicationmentioning
confidence: 99%
“…Several animal models with injuries to the infraorbital nerve or inferior alveolar nerve have been generated, which demonstrated mechanical or thermal hypersensitivity. 11,20,27,29,31 We have recently proposed that the inferior alveolar and mental nerve transection (IAMNT), 2 distal branches of the mandibular trigeminal nerve, serves as a valid neuropathic pain model in the trigeminal system. 22 We found in this model that while glial cell activation in medullary dorsal horn contributed to tactile hypersensitivity, neuronal loss of TG did not.…”
mentioning
confidence: 99%
“…Since HCN channels are active at resting membrane potentials in sensory neurons (Ingram and Williams 1996), HCN channels are likely to contribute to neuron excitability. I h density and the rate of activation are increased in dorsal root (DRG) and trigeminal ganglion (TG) neurons following peripheral nerve injury (Chaplan et al 2003;Yao et al 2003;Tsuboi et al 2004;Kitagawa et al 2006) and HCN channel immunoreactivity is increased in TG neurons (Wells et al 2007) but not DRG neurons following peripheral nerve injury (Chaplan et al 2003). Furthermore, specific blockade of I h alleviates mechanical allodynia and reduces ectopic discharges after nerve injury, both in vivo and in vitro (Chaplan et al 2003;Lee et al 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Seven days after the surgical operation, that period was confirmed to exhibit a hyperalgesic response in a formalin test [7,8]; animals were placed in Plexiglass testing chambers and allowed to acclimate for at least 60 min. A mirror was placed behind the chamber to obstacle-view the orofacial behavior.…”
Section: Methodsmentioning
confidence: 99%
“…Several lines of evidence show that aberrant nociceptive activities not only in the affected nerve, but also in the neighboring intact nerve are induced after injury of the spinal nerve [2,3,4,5,6] and trigeminal nerve [7,8]. The precise pathophysiological mechanisms of each model are largely unknown.…”
Section: Introductionmentioning
confidence: 99%