Alteration of rCBF in Alzheimer's disease patients with delusions of theft

Fukuhara, Ryuji; Ikeda, Manabu; Nebu, Akihiko; Kikuchi, Takanori; Maki, Naruhiko; Hokoishi, Kazuhiko; Shigenobu, Kazue; Komori, Kenjiro; Tanabe, Hirotaka

doi:10.1097/00001756-200108080-00037

Cited by 45 publications

(32 citation statements)

References 18 publications

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“…However, it has been suggested that different types of delusions in AD patients have discrete neurological pathophysiologies. In line with this hypothesis, a previous study demonstrated that rCBF in the medial posterior parietal region was decreased in patients with delusions of theft compared with those without delusions [17] . In accordance with this result, we also found significant hypoperfusion in the posterior regions in patients with delusions of theft.…”

Section: Discussionmentioning

confidence: 54%

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Insular Hypoperfusion Correlates with the Severity of Delusions in Individuals with Alzheimer’s Disease

Matsuoka

Narumoto²,

Shibata³

et al. 2010

Dement Geriatr Cogn Disord

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Background: The aim of this study was to identify the brain regions associated with the severity of delusions in individuals with Alzheimer’s disease (AD) using single-photon emission computed tomography. Methods: Thirty-five AD patients participated in this study. Multiple regression analysis was performed to identify a linear correlation between the delusion subscale score of the Neuropsychiatric Inventory (NPI) and regional cerebral blood flow (rCBF) in AD patients with delusions (n = 14). In addition, rCBF in patients with (n = 14) and without delusions (n = 21) was compared using a 2-sample t test. Results: The delusion subscale score of the NPI was negatively correlated with rCBF in the right anterior insula (uncorrected p < 0.01 at the voxel level and corrected p < 0.05 at the cluster level). Compared to patients without delusions, however, rCBF in the right anterior insula was not significantly decreased in patients with delusions. Conclusion: We suggest that right anterior insular dysfunction may exacerbate delusions, although it is not responsible for the onset of delusions.

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Section: Discussionmentioning

confidence: 54%

“…When the liberal threshold (p ! 0.01, uncorrected, k 1 50), which is similar to the threshold used in the previous studies [11,12,17] , was applied, the rCBF in the posterior cingulate and the bilateral cerebellum was significantly decreased in those with delusions ( table 4 ; fig. 2 ).…”

Section: Two-sample T Testmentioning

confidence: 81%

Insular Hypoperfusion Correlates with the Severity of Delusions in Individuals with Alzheimer’s Disease

Matsuoka

Narumoto²,

Shibata³

et al. 2010

Dement Geriatr Cogn Disord

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“…Several researchers have also demonstrated relationships between delusions and cerebral regions in AD. For example, Fukuhara et al [30] found an association between delusions and right medial posterior parietal hypoperfusion. Staff et al [9] noted a relation between delusions and right frontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease

Nakano

Yamashita

Matsuda

et al. 2005

Dement Geriatr Cogn Disord

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To investigate the association between delusions and cerebral functional deficits in Alzheimer’s disease (AD), we evaluated probable AD patients with and without delusions. Methods: Functional brain imaging was performed by single photon emission computed tomography with technetium-99m-labeled ethyl cysteinate dimer (^99mTc-ECD) in 64 AD patients and 76 age-matched normal healthy volunteers. SPECT data were analyzed by statistical parametric mapping. Results: In AD patients, no differences were found in age and cognitive activities between those with (n = 25) and without (n = 39) delusions. Compared with normal healthy volunteers, AD patients had significantly decreased perfusion in the posterior cingulate gyri, precunei, and parietal association cortex. Moreover, in the patients with delusions, perfusion was significantly decreased in the frontal lobe with right side dominance. In the comparison between the patients with and without delusions, the patients with delusions had significantly decreased perfusion in the prefrontal cortex, anterior cingulate gyri, inferior to middle temporal cortices, and parietal cortex of the right hemisphere (p < 0.01). Conclusion: The functional deficits in the right hemisphere may be the cause of delusions in AD.

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“…77.3% of Japanese females over 50 years of age manage their family living expenses alone (Ehime Women's Foundation, 2000). Biological aspects such as cortical dysfunction (Ponton et al, 1995;Staff et al, 1999;Fukuhara et al, 2001) as well as psychosocial and environmental aspects such as the contribution rate to household matter and living with or without caregivers as well as biological aspects such as cortical dysfunction (Ponton et al, 1995;Staff et al, 1999;Fukuhara et al, 2001) may be important to consider when to exploring AD delusions in future studies.…”

Section: Discussionmentioning

confidence: 99%