Delusions of Japanese patients with Alzheimer's disease

Ikeda, Manabu; Shigenobu, Kazue; Fukuhara, Ryuji; Hokoishi, Kazuhiko; Nebu, Akihiko; Maki, Naruhiko; Nomura, Michie; Komori, Kenjiro; Tanabe, Hirotaka

doi:10.1002/gps.864

Cited by 46 publications

(58 citation statements)

References 42 publications

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“…However, the mechanism for delusions in AD patients is not well understood. Some studies which did not use an age limit reported that being female is linked to delusions in AD Launer et al, 1999;Ikeda et al, 2003). Therefore, there is a possibility that our results were strongly influenced by sex ratio.…”

Section: Discussioncontrasting

confidence: 52%

Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease

Toyota

Ikeda

Shinagawa

et al. 2007

Int J Geriat Psychiatry

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Section: Discussioncontrasting

confidence: 52%

Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease

Toyota

Ikeda

Shinagawa

et al. 2007

Int J Geriat Psychiatry

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“…Female predominance in delusion was also evident in this study. The discrepancy between Western countries and Japan may be attributed to methodological and sociocultural differences, as suggested by Ikeda et al [6] .…”

Section: Discussionmentioning

confidence: 89%

“…The prevalence of delusions was reported as 22% by Mega et al [20] , 46.7% by Ozawa [21] , 38.6% by Hirono et al [22] , 55% by Wilson et al [23] , and 47.3% by Ikeda et al [6] . In this study, 39.1% of the AD patients exhibited delusions, with this fi gure well within the range reported in the previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease

Nakano

Yamashita

Matsuda

et al. 2005

Dement Geriatr Cogn Disord

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To investigate the association between delusions and cerebral functional deficits in Alzheimer’s disease (AD), we evaluated probable AD patients with and without delusions. Methods: Functional brain imaging was performed by single photon emission computed tomography with technetium-99m-labeled ethyl cysteinate dimer (^99mTc-ECD) in 64 AD patients and 76 age-matched normal healthy volunteers. SPECT data were analyzed by statistical parametric mapping. Results: In AD patients, no differences were found in age and cognitive activities between those with (n = 25) and without (n = 39) delusions. Compared with normal healthy volunteers, AD patients had significantly decreased perfusion in the posterior cingulate gyri, precunei, and parietal association cortex. Moreover, in the patients with delusions, perfusion was significantly decreased in the frontal lobe with right side dominance. In the comparison between the patients with and without delusions, the patients with delusions had significantly decreased perfusion in the prefrontal cortex, anterior cingulate gyri, inferior to middle temporal cortices, and parietal cortex of the right hemisphere (p < 0.01). Conclusion: The functional deficits in the right hemisphere may be the cause of delusions in AD.

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“…알츠하이머병 환자에서 망상의 유병률은 10-73%로 보고되고 있 으며 [17], 최근 연구에서는 알츠하이머병 환자의 약 삼분의 일에서 망 상이 있다고 보고되었다 [17][18][19][20]. 따라서 환경적인 조절이 중요하다 [73].…”

Section: 유병률unclassified

Delusions in Alzheimer's Disease

Kwak

Yang

Koo

2014

Dement Neurocognitive Disord

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Alzheimer's disease (AD) is associated with cognitive and functional impairment as well as neuropsychiatric complications, including psychotic symptoms such as delusions and hallucinations. Recent studies strongly suggest that delusions should be separated from hallucinations. While AD with delusions is a phenotypically distinct from AD without delusions, subtypes of delusions may also define further distinct clinical entities. There has been also considerable debate as to whether delusions in patients with AD differ etiologically, phenomenologically, and therapeutically from delusions in other primary psychiatric illnesses. In other words, whether they are caused by changes to key areas of the brain that have been linked to the presence of delusions. This has led to speculation that these symptoms may respond better to certain drugs such as cholinesterase inhibitors. Integrating the epidemiology, clinical phenomenology, neuropathological and genetic literature for delusions in AD allows us to speculate on pathophysiology and is essential to making progress in the area of delusions in AD.

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Delusions of Japanese patients with Alzheimer's disease

Abstract: The authors found a high frequency of delusions, particularly of delusions of theft and suggested that gender was associated with the expression of delusions in Japanese patients with AD.

Cited by 46 publications

References 42 publications

Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease

Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease

Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease

Delusions in Alzheimer's Disease

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