Alteration of monoamine concentrations in the brain of medaka, <i>Oryzias latipes,</i> exposed to tributyltin

Nakayama, Kei; Oshima, Yuji; Tachibana, Tetsuya; Furuse, Mitsuhiro; Honjo, Tasuku

doi:10.1002/tox.20233

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…한편 어류에 대한 TBT의 영향에 대한 연구는 TBT의 현장 농도와 어류의 조직 및 혈액 내의 축적 (Senthikumar et al, 1999;Miki et al, 2011)이 있으며, 행동학적 측면에서는 시각과 청각기능의 변화 (Wang and Huang, 1999), 유영행동 및 뇌의 monoamine 농도 변화 (Schmidt et al, 2005;Nakayama et al, 2006)에 대한 연구가 있다. 또한 TBT 노출에 따른 어류는 호르 몬 및 면역시스템의 변화 (Mortensens and Arukwe, 2007;Nakayama et al, 2007)) 등이 나타나며, cytochrome P450 시스템을 억제시킴으로서 독성물질의 해독능력의 저 하와 ATP(adenosine triphosphate) 합성저해로 인한 생체 에너지대사 방해 등 다양한 저해영향을 나타낸다는 보고가 있다 (Fent and Stegeman, 1991). (Khattak and Hafeez, 1996), 이들 지표를 통하여 노출 된 독성물질에 대한 정보를 추정할 수 있다 (Leroy, 1993 독성물질에 대해 어류는 신장 기능의 장애가 발생 하는데 이는 조혈기관의 손상을 의미하며 (Witters et al, 1990), Hb 농도와 Ht 값의 변동은 혈액의 pH 변동 으로 세포의 삼투이동에 영향을 미치기 때문이다 (Milligan and Wood, 1982).…”

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Changes of Growth and Hematological Constituents in the Rock Bream Oplegnathus fasciatus Exposed to TBT

Hwang¹,

Kim²,

Kang³

2013

Journal of fish pathology

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Experiments were carried out to investigate the growth and hematological parameters of rock bream Oplegnathus fasciatus exposed to several different concentrations (0, 1, 2, 4, 8 ㎍/L) of tributyltin (TBT) for 4 weeks. Growth rate of the fish exposed to 8 ㎍/L of TBT concentration was significantly lower than that of control group fish. The major hematological findings were significant decreases in the red blood cell count, hematocrit value and hemogobin concentration in the fish exposed to 8 ㎍/L. Although serum glucose concentration was significantly reduced compared to the control group, total protein concentration was found to be significantly increased over the control group.Exposure to 8 ㎍/L of TBT concentration resulted in significant increase in the enzyme activities, such as glutamic oxalate transminase and glutamic pyruvate transminase in the fish. The present findings suggest that exposure to 8 ㎍/L concentration of TBT can cause significant changes in growth and hematological parameters of rock bream Oplegnathus fasciatuso.

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Changes of Growth and Hematological Constituents in the Rock Bream Oplegnathus fasciatus Exposed to TBT

Hwang¹,

Kim²,

Kang³

2013

Journal of fish pathology

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Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes

Ohji

Harino

2017

Arch Environ Contam Toxicol

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Japanese killifish Oryzias latipes were exposed to three levels (0, 1, and 10 µg l) of copper pyrithione (CuPT), zinc pyrithione (ZnPT), six of their degradation products, and the organotin compounds tributyltin (TBT) and triphenyltin (TPT) for 48 h at 20 °C. All individual fish exposed to 1 and 10 µg l of CuPT or 10 µg l of ZnPT were dead within 12 h, respectively, and at 24 h the survival rate of the fish exposed to 1 µg l of ZnPT was 50%. All fish exposed to 10 µg l of ZnPT showed morphological abnormalities in the form of vertebral deformity. None of the fish exposed to six of the degradation products of PTs, TBT, and TPT died during a 48-h exposure period, but various biological effects were observed in the fish exposed to these chemicals: abnormalities of respiration and swimming behavior, and decreased hatchability. Our findings suggest that O. latipes has a higher ecological risk of CuPT and ZnPT exposure than of TBT and TPT exposure during their life history. Because these antifouling biocides have been used in both freshwater and marine environments, our results highlight these biocides' deleterious effects on the freshwater fish as well as marine fish, and they indicate freshwater and marine pollution.

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Tributyltin bioaccumulation and toxic effects in freshwater gastropods Pomacea canaliculata after a chronic exposure: field and laboratory studies

et al. 2017

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Freshwater samples and gastropod mollusks (Pomacea canaliculata) were collected at 5 sampling stations located along the lower Río de la Plata basin, Argentina, to assess the extent of tributyltin (TBT) contamination. Determined data revealed the presence of TBT and some of its breakdown products (dibutyltin: DBT, and monobutyltin: MBT) in all freshwater samples and also in soft tissues of P. canaliculata gastropods. Chronic bioassays (6 months) were performed using female gastropods that had been reared under laboratory conditions and exposed to a similar TBT concentration than the value determined in freshwater samples (1 µg L). The aims of this study were to evaluate the extent of TBT accumulation, the tissue distribution, and the effects on selected biomarkers (activity of superoxide dismutasa: SOD, activity of catalase: CAT, levels of total glutathione: t-GSH, lipid peroxidation, and activity of acetylcholinesterase: AChE). Gonads presented the highest accumulation, followed by the cephalopedal region, albumin gland, and finally hepatopancreas. Both metabolites, DBT and MBT, were also found. All exposed female animals presented development of a penis reflecting the potential of TBT as an endocrine disrupting chemical for this gastropod species. Results on the selected biomarkers confirmed additional adverse effects induced by TBT. An increase in CAT activity and changes in t-GSH levels are indicative of alterations on the cellular redox status. The inhibition of AChE could reflect signs of neurotoxicity. Altogether, these results reveal a negative impact on the health of this gastropod population.

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Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Cited by 10 publications

References 24 publications

Changes of Growth and Hematological Constituents in the Rock Bream Oplegnathus fasciatus Exposed to TBT

Changes of Growth and Hematological Constituents in the Rock Bream Oplegnathus fasciatus Exposed to TBT

Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes

Tributyltin bioaccumulation and toxic effects in freshwater gastropods Pomacea canaliculata after a chronic exposure: field and laboratory studies

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