Alteration of maternal serum irisin levels in gestational diabetes mellitus

Abstract

Objectives: The aim of our study was to compare serum irisin concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Material and methods:This study was performed at the Tertiary Care Center, Department of Obstetrics and Gynecology, between January 2014 and April 2014. A total of 45 pregnant women with GDM (diabetes group) and 41 BMI-and age-matched healthy pregnant women (control group) were recruited. Maternal serum irisin levels were measured by enzyme-linked immunosorbent assay kit at 24-28 weeks of gestation. An association between maternal serum irisin levels and metabolic parameters was analyzed. Body mass index, serum levels of glucose, insulin and irisin were tested and analyzed in the study group and controls.Results: Pregnant women with GDM had significantly higher fasting plasma glucose (p = 0.001), first-hour OGTT glucose (p = 0.001), second-hour OGTT glucose (p = 0.001), and fasting insulin (p = 0.045) levels as compared to controls. Serum irisin levels were 1.04 ± 0.3 and 1.3 ± 0.2 in pregnant women with GDM and healthy pregnant controls, respectively (p = 0.001). Correlation analysis between irisin levels and anthropometric and biochemical parameters in patients with gestational diabetes revealed that none of the investigated parameters correlated with serum irisin level. Conclusions:Our results suggest that serum irisin levels might be introduced as a novel marker for GDM, with decreased levels of irisin being indicative of GDM.

Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus

“…Therefore, we believe that these associations were dependent on the maternal weight and BMI. A similar finding was reported that irisin was positively related with BMI and FBG [39], yet another study reported that none of the anthropometric parameters to correlate with serum irisin levels [40]. Another study's findings suggested that irisin was negatively correlated with age and FBG while positively 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 Table 2.…”

“…correlated with HDL-c [41]. Interestingly, Sinanoglu and group [40] proposed an ethnicity and maternal age related link with the fat content of colostrum instead of the commonly agreed notion of maternal pre pregnancy BMI. They also suggest that this finding can be used to design custom diets for mothers to enhance the mature breast milk nutritional value and in turn have a positive impact on new born health.…”

The Exercise-Induced Irisin Is Associated with Improved Levels of Glucose Homeostasis Markers in Pregnant Women Participating in 8-Week Prenatal Group Fitness Program: A Pilot Study

“…Kuzmicki et al also observed that serum irisin increases markedly in pregnant women, but this increase seems to be significantly lower in patients with GDM [ 11 ]. The study by Ural et al [ 12 ] supports these data. Thereby irisin may be a useful biomarker in early pregnancy to predict the development of GDM [ 13 ].…”

“…An important finding is that among our participants the decreasing irisin was not associated with complications during pregnancy, as the results of previous studies would suggest. Other authors observed that in women with gestational diabetes mellitus the irisin concentration was lower than in healthy subjects [ 10 – 12 ]. In our study group of physically active pregnant women we have not reported any case of GDM or preeclampsia.…”

Serum and Adipose Tissue mRNA Levels of ATF3 and FNDC5/Irisin in Colorectal Cancer Patients With or Without Obesity

“…However, a negative correlation between irisin and TG has been reported in overweight/obese children and adolescents aged 6 to 10 years old ( Suk et al, 2018 ). Alternatively, no correlation between irisin and TG was reported in pregnant women with gestational diabetes mellitus ( Ural et al, 2016 ). Thus, given that our present study is the first to demonstrate an association between irisin and TG in CRC patients, the relationship should be further assessed in future studies.…”