Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus

Fatima, Syeda Sadia; Khalid, Erum; Ladak, Asma Akbar; Ali, Syed Adnan

doi:10.1080/14767058.2018.1454422

Cited by 19 publications

(11 citation statements)

References 47 publications

(49 reference statements)

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“…Salusin-alpha and -beta levels were lower in colostrum of women with GDM [23]. SREBP1-c profile showed a level reduced from a very low value to an undetectable range in colostrum and mature breast milk, respectively [21].…”

Section: Hormonesmentioning

confidence: 90%

Section: Hormonesmentioning

confidence: 94%

“…Irisin concentrations, analyzed in two studies, were accordingly found to be low in GDM subjects in the colostrum and transitional milk [21,22]. In mature milk, Fatima et al observed a reduction in concentrations, not confirmed by Aydin et al [21,22]. In addition, the study by Aydin et al found Irisin levels to increase from the colostrum to transitional and mature milk in both normal glucose tolerant and GDM patients [22].…”

Section: Hormonesmentioning

confidence: 97%

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Influence of Diabetes during Pregnancy on Human Milk Composition

Peila

Gazzolo²,

Bertino

et al. 2020

Nutrients

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Human milk (HM) is a unique nourishment believed to contain biological factors contributing to both short and long-term benefits. Considering that a mother’s own milk is often considered the first choice for nutrition of neonates, an aspect of increased interest is the possible effect of diabetes on the mammary gland and therefore on breast milk composition. This article aims to review the published literature on this topic, and to offer additional insights on the role of this disease on the composition of HM. This review was performed by searching the MEDLINE, EMBASE, CINHAL and Cochrane Library databases. A total of 50 articles were selected, focused specifically on one of the two types of diabetes: gestational diabetes mellitus (21 studies) and insulin-dependent diabetes mellitus (8 studies). Overall, the findings from the literature suggest that diabetes can alter the composition of HM. Nevertheless, the studies in this field are scarce, and the related protocols present some limitations, e.g., evaluating the variability of just a few specific milk biochemical markers in association with this syndrome.

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Section: Hormonesmentioning

confidence: 90%

Section: Hormonesmentioning

confidence: 94%

Section: Hormonesmentioning

confidence: 97%

See 1 more Smart Citation

Influence of Diabetes during Pregnancy on Human Milk Composition

Peila

Gazzolo²,

Bertino

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Unsurprisingly, the breast milk of the GDM patients had lower concentrations of irisin that of the control group, regardless of colostrum or mature milk [ 140 ]. Additionally, Fatima et al speculated that unfavorable effects on health and lipid regulation may stem from continuous feeding of breast milk with fewer irisin [ 144 ]. The remarkable connection between low irisin levels in breast milk and infant weight require further investigation.…”

Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

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Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

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“…The composition of human milk depends on many factors (e.g., period of the milk, time of day when milk is obtained, mother’s nutritional status, and age of the newborn; Dritsakou, Liosis, Valsami, Polychronopoulos, & Skouroliakou, 2018). Human milk is divided into three basic categories according to the period of secretion and composition: colostrum (milk secreted for the first 5 days after birth [postpartum]), transitional milk (milk secreted between 5 and 15 days after colostrum [transitional]) and mature milk (milk secreted after the 15th day [mature]; Fatima, Khalid, Ladak, & Ali, 2018). Although the nutritional content of these varieties of milk differ, the content generally varies according to the physiological needs of the child (Mazurier et al, 2017; Aydin, 2018).…”

Section: Introductionmentioning

confidence: 99%

Chemerin and Dermcidin in Human Milk and Their Alteration in Gestational Diabetes

et al. 2019

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Background: Chemerin and dermcidin, which have antimicrobial properties, are molecules that are also related to insulin resistance and inflammation. Research aims: The aims were to determine the amounts of chemerin and dermcidin in the milk and blood of mothers with gestational diabetes, and to compare the amounts of chemerin and dermcidin in the milk and blood of mothers with and without diabetes. Methods: This was a two-group nonrandomized longitudinal study with a convenience sampling of mothers without gestational diabetes ( n = 27) and mothers with gestational diabetes ( n = 26). Human milk and blood samples were obtained from these mothers during colostrum, transitional, and mature milk periods. The amount of chemerin and dermcidin in these samples was measured by enzyme-linked immunosorbent assay. Results: The presence of chemerin and dermcidin was first detected in human milk. The amounts of chemerin and dermcidin in the blood of all the mothers were greater in the colostrum period and lowest in the mature period. The amount of chemerin and dermcidin in the milk of all the mothers was greater than that in the blood. The amounts of chemerin and dermcidin were significantly increased in both blood and human milk within the gestational age samples. Conclusions: Chemerin and dermcidin may contribute to the protection of infants from infections during infancy. Increased amounts of these molecules found within the gestational diabetes group may also prevent adverse maternal and fetal outcomes.

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Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus

Cited by 19 publications

References 47 publications

Influence of Diabetes during Pregnancy on Human Milk Composition

Influence of Diabetes during Pregnancy on Human Milk Composition

The Role of the Adipokines in the Most Common Gestational Complications

Chemerin and Dermcidin in Human Milk and Their Alteration in Gestational Diabetes

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