Alteration of major cytokines produced by mitogen-activated peritoneal macrophages and splenocytes in T-2 toxin-treated male CD-1 mice

Dugyala, Raviprakash R.; Sharma, Raghubir P.

doi:10.1016/s1382-6689(96)00142-1

Cited by 9 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inhibitory effect on protein synthesis was more remarkable than on RNA synthesis. ), decreased production of TNF, IL-1 and IL-6 was noted on peritoneal macrophages stimulated with LPS (Dugyala and Sharma, 1997). Similarly, mouse peritoneal macrophages exposed in vitro to T-2 toxin (46 µg/L) displayed a reduced phagocytic activity on Pseudomonas aeruginosa.…”

Section: Effect On Inflammatory Cellsmentioning

confidence: 88%

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

2011

EFSA Journal

277

102

View full text Add to dashboard Cite

T-2 toxin and HT-2 toxin are mycotoxins produced by various Fusarium species. The European Commission asked EFSA for a scientific opinion on the risk to human and animal health related to the presence of T-2 and HT-2 toxin in food and feed. A total of 20,519 results for the sum of T-2 and HT-2 toxins in food, feed and unprocessed grains, collected in 2005-2010 from 22 European countries, were used in the evaluation. The highest mean concentrations for the sum of T-2 and HT-2 toxins were observed in grains and grain milling products, notably in oats and oat products. Grains and grain-based foods, in particular bread, fine bakery wares, grain milling products, and breakfast cereals, made the largest contribution to the sum of T-2 and HT-2 toxin exposure for humans. T-2 toxin is rapidly metabolised to a large number of products, HT-2 toxin being a major metabolite. Pigs are amongst the most sensitive animals towards the effects of T-2 toxin, the most sensitive endpoints being immunological or haematological effects. Using these data and a benchmark dose analysis the Panel on Contaminants in the Food Chain established a group tolerable daily intake (TDI) of 100 ng/kg b.w. for the sum of T-2 and HT-2 toxins. Estimates of chronic human dietary exposure to the sum of T-2 and HT-2 toxins based on the available occurrence data are below the TDI for populations of all age groups, and thus not a health concern. For ruminants, rabbits and farmed fish the estimated exposures to the sum of these toxins based on the available occurrence data are considered unlikely to be a health concern, while for pigs, poultry, dogs and horses the risk of adverse health effects is low. For cats the health risk from the exposure to T-2 and HT-2 toxins cannot be assessed.

show abstract

Section: Effect On Inflammatory Cellsmentioning

confidence: 88%

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

2011

EFSA Journal

277

102

View full text Add to dashboard Cite

show abstract

“…FB 1 inhibited the LPS-induced expression of IL-6 in human dendritic cells (DCs) [25], whereas the modulation of FB 1 toxicity in the brain of female BALB/c mice; FB 1 augments the LPS-induced IL-6 expression in the brain [26]. The effects of in vivo exposure to T-2 toxin on the alteration of IL-6 in lipopolysaccharide-stimulated peritoneal macrophages [27]; IL-6 mRNA from activated peritoneal macrophages showed no significant differences between the control and the treatment groups. The effects of different Fusarium toxins on IL-6 varied because of differences in toxicities and animal models.…”

Section: Discussionmentioning

confidence: 99%

Effects of Zearalenone on IL-2, IL-6, and IFN-γmRNA Levels in the Splenic Lymphocytes of Chickens

Wang

Deng

Shi

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

Zearalenone (ZEN) is an estrogenic mycotoxin produced by severalFusariumspecies, which can contaminate food and feed. These compounds elicit a wide spectrum of toxic effects, including the capacity to alter normal immune function. In this study, the in vitro effects of the treatment of ConA-stimulated splenic lymphocytes with ZEN (0–25 μg/mL) were examined. ZEN modulates the expression of IL-2, IL-6, and IFN-γ. The IL-2 levels were up to fourfold higher (P<0.05) compared with the levels in the control at toxin concentrations of 25 μg/mL after 48 h of treatment. The IL-6 levels were critically suppressed at this concentration; these changes were very statistically significant (P<0.05). At lower ZEN concentrations (0.1, 0.4 and 1.6 μg/mL), the IFN-γlevels changed slightly; however at 6.25 and 25 μg/mL, the IFN-γresults reached statistical significance compared with the control levels (P<0.05). These data suggest that ZEN has potent effects on the expression of chicken splenic lymphocytes cytokines at the mRNA level.

show abstract

Immunotoxicity

Sharma¹

2007

Veterinary Toxicology

View full text Add to dashboard Cite

Alteration of major cytokines produced by mitogen-activated peritoneal macrophages and splenocytes in T-2 toxin-treated male CD-1 mice

Cited by 9 publications

References 39 publications

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

Effects of Zearalenone on IL-2, IL-6, and IFN-γmRNA Levels in the Splenic Lymphocytes of Chickens

Immunotoxicity

Contact Info

Product

Resources

About