Alteration of humoral responses to Candida in HIV infection

Wray, D. Walter; Felix, David H; Cumming, C. G.

doi:10.1038/sj.bdj.4807186

Cited by 29 publications

(25 citation statements)

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“…), 12 C. albicans being the most frequent species observed. [12][13][14] Therefore, a decreased level of S-IgA would permit colonization and development of oral candidiasis. However, the role of specific antibody in protecting mucosal surfaces has not been elucidated.…”

Section: Introductionmentioning

confidence: 98%

“…7 One of these proteins is salivary secretory immunoglobulin A (S-IgA), which affords protection by inhibiting microorganisms' adhering to and penetrating mucosal tissues, 8,9 including Candida albicans, 10,11 an etiological agent of oral candidiasis. 12 HIV-infected patients are generally colonized with Candida species (spp. ), 12 C. albicans being the most frequent species observed.…”

Section: Introductionmentioning

confidence: 99%

“…12 HIV-infected patients are generally colonized with Candida species (spp. ), 12 C. albicans being the most frequent species observed. [12][13][14] Therefore, a decreased level of S-IgA would permit colonization and development of oral candidiasis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Levels of salivary IgA antibodies to Candida spp. in HIV-infected adult patients: A systematic review

Pomarico¹,

Souza²,

Castro³

et al. 2010

Journal of Dentistry

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Levels of salivary IgA antibodies to Candida spp. in HIV-infected adult patients: A systematic review

Pomarico¹,

Souza²,

Castro³

et al. 2010

Journal of Dentistry

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“…varies from 35-38% 1,29 to 40-60% 13 . C. albicans can be isolated from the oral cavity of 5-7% of newborns few hours after birth.…”

Section: Introductionmentioning

confidence: 99%

Effects of oral environment stabilization procedures on counts of Candida spp. in children

Rego

Koga-Ito

Jorge

2003

Pesqui. Odontol. Bras.

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ABSTRACT:The effects of oral environment stabilization procedures on counts of Candida spp. have rarely been discussed, and no conclusive results are found in the literature. The aim of this study was thus to ascertain the effects of oral environment stabilization procedures with glass ionomer and zinc oxide-eugenol cements on counts of Candida spp. in the oral cavity of children. For this purpose, oral rinses of sterile phosphate-buffered saline were initially collected from 30 boys and 30 girls, positive for Candida in the saliva and aged from 4 to 10 years. Data on the initial quantity of CFU/ml of Candida were obtained. Then, the children were randomly divided into two groups and oral environment stabilization procedures were performed using zinc oxide-eugenol cement or glass ionomer cement. One week after the procedures were performed, oral rinses were collected again and final Candida counts were obtained. An expressive reduction in Candida counts was observed in both groups. The zinc oxide-eugenol and glass ionomer cements were efficient in the reduction of Candida counts and statistically significant differences were observed between initial and final counts in both groups. Considering the percentage of reduction, the zinc oxide-eugenol cement presented more favorable results, with a reduction of 70%. A reduction of 46% was observed with the use of the glass ionomer cement. According to the obtained results, we concluded that oral environment stabilization procedures were efficient in reducing Candida spp. counts, especially when the zinc oxide-eugenol cement was employed. DESCRIPTORS:Candida; Zinc oxide-eugenol cement; Glass ionomer cement. RESUMO:O efeito da adequação de meio sobre contagens de Candida spp. na cavidade bucal tem sido pouco discutido e nenhum resultado conclusivo foi encontrado na literatura. Desse modo, o objetivo do presente trabalho foi verificar os efeitos da adequação de meio bucal, utilizando cimento de óxido de zinco e eugenol e cimento de ionômero de vidro, sobre contagens desses microorganismos em crianças. Foram coletados enxágües bucais de 30 meninos e 30 meninas com idades entre quatro e dez anos, positivos para Candida na saliva, obtendo-se a contagem inicial. As crianças foram divididas ao acaso em dois grupos e procedeu-se à adequação de meio utilizando um dos cimentos a serem testados. Uma semana depois, novo enxágüe bucal foi coletado, obtendo-se, dessa forma, a contagem final de Candida spp. Uma redução expressiva nas contagens foi observada em ambos os grupos. Os dois materiais testados foram eficazes na diminuição das contagens de Candida, e diferenças estatisticamente significantes foram observadas entre as contagens inicial e final nos dois grupos. Considerando o percentual de redução, o cimento de óxido de zinco e eugenol apresentou resultados mais favoráveis, promovendo uma redução de 70%, ao passo que para o cimento de ionômero de vidro esse valor foi de 46%. De acordo com os resultados obtidos, concluiu-se que a adequação de meio é um procedimento eficaz na red...

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“…All 8 patients were using anti-retroviral therapies without clinical disease. It is well known that HIV is an important factor for Candida colonization of the oral cavity 18,28 . HCV and CMV infections did not influence salivary Candida carriage.…”

Section: Discussionmentioning

confidence: 99%

Candida in saliva of Brazilian hemophilic patients

et al. 2004

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emophilia is a common hereditary hemorrhagic disorder, however little is known about the oral microflora of hemophilic patients. The aim of this study was to quantify the Candida and identify its species in non-stimulated saliva of hemophilic patients, and consider its relationship with clinical factors influencing Candida carriage. This study comprised evaluation of 86 hemophilic patients of the Hematology Center/UNICAMP and 43 healthy subjects as controls. All patients were submitted to anamnesis, intraoral examination and unstimulated saliva collection. Candida counts and species identification were performed in salivary samples. Candida was present in 64% of the hemophilic patients and in 44% of the healthy controls. C. albicans represented 65% and 68% of the isolated species, in hemophiliacs and control group respectively, and C. tropicalis was the second most common species in both groups. These results indicate that hemophilic patients carry Candida more frequently and in higher counts than healthy controls, independently of oral clinical parameter considered, as viral infections, complete dentures, transfusions of hemoderivatives, and salivary flow. Uniterms: Candida; Hemophiliacs; Candidosis; Hemophilia; Candida tropicalis. emofilia é uma alteração hemorrágica hereditária comum, entretanto pouco se sabe a respeito da microbiota oral destes indivíduos. O objetivo deste estudo foi quantificar a presença de Candida e identificar as suas espécies na saliva de hemofílicos, correlacionando os resultados com fatores clínicos que possam influenciar a presença deste fungo. Foram avaliados 86 hemofílicos do Hemocentro/UNICAMP e 43 indivíduos saudáveis. Todos os pacientes foram submetidos a anamnese, exame clínico intra-oral e coleta de saliva de forma não estimulada. A quantificação e identificação das espécies de Candida foram realizadas nas amostras de saliva. Candida estava presente em 64% dos hemofílicos e em 44% dos indivíduos saudáveis. C. albicans representou 65% e 68% das espécies identificadas, nos hemofílicos e grupo controle respectivamente, e C. tropicalis foi a segunda espécie mais comum. Estes resultados sugerem que pacientes hemofílicos albergam mais freqüentemente Candida na cavidade bucal e em maiores quantidades que os indivíduos do grupo controle, independentemente dos parâmetros clínicos analisados, como infecção viral, próteses dentárias, transfusões de hemoderivados e fluxo salivar.

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Alteration of humoral responses to Candida in HIV infection

Cited by 29 publications

References 0 publications

Levels of salivary IgA antibodies to Candida spp. in HIV-infected adult patients: A systematic review

Levels of salivary IgA antibodies to Candida spp. in HIV-infected adult patients: A systematic review

Effects of oral environment stabilization procedures on counts of Candida spp. in children

Candida in saliva of Brazilian hemophilic patients

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