Alteration of Human Tumor Cell Adhesion by High-Strength Static Magnetic Fields

Short, Welland O.; Goodwill, Linda; Taylor, Charles W.; Job, Constantin; Arthur, Marvin E.; Cress, Anne E.

doi:10.1097/00004424-199210000-00014

Cited by 34 publications

(15 citation statements)

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“…It was suggested that the reduction in adherence is caused by a field-induced structural change in the integrin molecules located on the cell surfaces. This structure is presumed to subsequently affect the transmembrane signal transduction, finally leading to a decrease in the cellular adhesive ability [32]. Here, the shrinkage of the treated cells to oval forms indicate, too, a reduction in the adhering ability of cells.…”

Section: Resultsmentioning

confidence: 89%

Magnetic fields of 10mT and 120mT change cell shape and structure of F-actins of periodontal ligament cells

Fan

Chao

et al. 2008

Bioelectrochemistry

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Section: Resultsmentioning

confidence: 89%

Magnetic fields of 10mT and 120mT change cell shape and structure of F-actins of periodontal ligament cells

Fan

Chao

et al. 2008

Bioelectrochemistry

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“…Actually there were multiple previous studies indicated that SMFs have more impacts on cancer cells than on non-cancer cells [5, 14, 29] and moderate intensity SMFs could increase the efficacy of some chemodrugs on cancer cells [11, 12, 30, 31]. Moreover, moderate intensity SMF was also shown to be able to reduce tumor growth and increase chemodrugs efficacy in mouse models [13, 30].…”

Section: Discussionmentioning

confidence: 99%

Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation

Zhang

Yang

et al. 2017

Oncotarget

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Increasing evidence shows that static magnetic fields (SMFs) can affect cell proliferation but mixed results have been reported. Here we systematically examined the effects of 1 T (Tesla) SMF, which is close to the SMF intensity that patients are exposed to MRI (magnetic resonance imaging) scanners in hospitals, for its effect on 15 different cell lines, including 12 human and 3 rodent cell lines. Our results show that 1 T SMF does not have apparent impact on cell cycle or cell death. However, at higher cell density, it reduced cell numbers in six out of seven solid human cancer cell lines. We found that both cell type and cell density had evident impacts on SMF effects. Moreover, the EGFR-Akt-mTOR pathway, which varies significantly between different cell types and densities, contributes to the differential effects of SMF. In addition, SMF also increases the efficacy of Akt inhibitors on cancer cell growth inhibition. Therefore 1 T SMF affects cell proliferation in a cell type- and cell density-dependent manner, and the inhibition effect of 1 T SMF on multiple cancer cells at higher cell density may indicate its clinical potential in late stage cancer therapy.

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“…This could help to explain why substrate adhesion is influenced by SMFs. Once again, the use of different fields can give different results, as for example with the inhibition of fibroblast adhesion in the presence of 60 and 1000 Hz EMFs, and melanoma cell adhesion in the presence of an SMF using a 4.7-T superconducting magnetic resonance imaging (MRI) magnet (Blumenthal et al, 1997b;Short et al, 1992).…”

Section: Differentiationmentioning

confidence: 99%