Alteration of development and gene expression induced by in ovo -nanoinjection of 3-hydroxybenzo[ c ]phenanthrene into Japanese medaka ( Oryzias latipes ) embryos

Chen, Kun; Tsutsumi, Yasushi; Yoshitake, Shuhei; Qiu, Xuchun; Xu, Hai; Hashiguchi, Yasuyuki; Honda, Masato; Tashiro, Kosuke; Nakayama, Kei; Hano, Takuzo; Suzuki, Nobuo; Hayakawa, Kazuichi; Shimasaki, Yohei; Oshima, Yuji

doi:10.1016/j.aquatox.2016.11.020

Cited by 11 publications

(3 citation statements)

References 54 publications

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“…In mammals, oxygenated PAHs, including monohydroxylated PAHs (OHPAHs), have been noted to be toxic substances [62]. In medaka embryos, as well as mammals, OHPAHs were toxic for embryogenesis [63].…”

Section: Toxicity Of Pahs On the Early Development Of Fishmentioning

confidence: 99%

“…By injecting 3-OHBcP (1 nM) in ovo, the development of medaka embryos on the first, fourth, and sixth days post fertilization (dpf) was promoted. On the fifth dpf after injecting 3-OHBcP, the heart rates of embryos in the 1 nM 3-OHBcP exposure group were significantly higher than those in the control and solvent control groups [63]. Using mRNA-Seq data analysis, the detailed mechanisms of these phenomena were investigated.…”

Section: Toxicity Of Pahs On the Early Development Of Fishmentioning

confidence: 99%

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Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Honda

Suzuki

2020

IJERPH

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341

126

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Polycyclic aromatic hydrocarbons (PAHs) are organic compounds that are widely distributed in the air, water, and soil. Recently, the amount of PAHs derived from fuels and from incomplete combustion processes is increasing. In the aquatic environment, oil spills directly cause PAH pollution and affect marine organisms. Oil spills correlate very well with the major shipping routes. Furthermore, accidental oil spills can seriously impact the marine environment toxicologically. Here, we describe PAH toxicities and related bioaccumulation properties in aquatic animals, including invertebrates. Recent studies have revealed the toxicity of PAHs, including endocrine disruption and tissue-specific toxicity, although researchers have mainly focused on the carcinogenic toxicity of PAHs. We summarize the toxicity of PAHs regarding these aspects. Additionally, the bioaccumulation properties of PAHs for organisms, including invertebrates, are important factors when considering PAH toxicity. In this review, we describe the bioaccumulation properties of PAHs in aquatic animals. Recently, microplastics have been the most concerning environmental problem in the aquatic ecosystem, and the vector effect of microplastics for lipophilic compounds is an emerging environmental issue. Here, we describe the correlation between PAHs and microplastics. Thus, we concluded that PAHs have a toxicity for aquatic animals, indicating that we should emphasize the prevention of aquatic PAH pollution.

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Section: Toxicity Of Pahs On the Early Development Of Fishmentioning

confidence: 99%

Section: Toxicity Of Pahs On the Early Development Of Fishmentioning

confidence: 99%

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals

Honda

Suzuki

2020

IJERPH

Self Cite

341

126

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“…Polluted seawater containing PAHs affects aquatic animals. PAHs were reported to induce oncogenesis, immune system disorders, and developmental defects in aquatic animals [6,7]. Therefore, it is essential to investigate the effect and mechanism of action of PAHs on marine invertebrates to predict their biological impact on the marine environment.…”

Section: Introductionmentioning

confidence: 99%

Effect of Polycyclic Aromatic Hydrocarbons on Development of the Ascidian Ciona intestinalis Type A

Sekiguchi

Akitaya

Nakayama

et al. 2020

IJERPH

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Polycyclic aromatic hydrocarbons (PAHs) are pollutants that exert harmful effects on marine invertebrates; however, the molecular mechanism underlying PAH action remains unclear. We investigated the effect of PAHs on the ascidian Ciona intestinalis type A (Ciona robusta). First, the influence of PAHs on early Ciona development was evaluated. PAHs such as dibenzothiophene, fluorene, and phenanthrene resulted in formation of abnormal larvae. PAH treatment of swimming larva induced malformation in the form of tail regression. Additionally, we observed the Ciona aryl hydrocarbon receptor (Ci-AhR) mRNA expression in swimming larva, mid body axis rotation, and early juvenile stages. The time correlation between PAH action and AhR mRNA expression suggested that Ci-AhR could be associated with PAH metabolism. Lastly, we analyzed Ci-AhR mRNA localization in Ciona juveniles. Ci-AhR mRNA was localized in the digestive tract, dorsal tubercle, ganglion, and papillae of the branchial sac, suggesting that Ci-AhR is a candidate for an environmental pollutant sensor and performs a neural function. Our results provide basic knowledge on the biological function of Ci-AhR and PAH activity in marine invertebrates.

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