Alteration of cortical EEG in mice carrying mutated human APP transgene

Wang, Jun; Ikonen, Sami; Gurevicius, Kestutis; Groen, Thomas van; Tanila, Heikki

doi:10.1016/s0006-8993(02)02617-3

Cited by 54 publications

(61 citation statements)

References 31 publications

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“…Our results are in agreement with the findings obtained using transgenic mice [5]. Unlike the transgenic model, in a case of beta-amyloid injection we did not observe the increase of oscillation power in the beta-band.…”

Section: Discussionsupporting

confidence: 92%

“…Transgenic mice with mutant forms of human APP, PS1, and PS2 are models of the genetic (familial) form AD that have resulted in significant contributions to understanding the molecular mechanisms of the disease [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…There are only a few studies of oscillation processes in the experimental models of AD [5,21]. The APP/PS1 mice showed reduced cortical theta activity (5 Hz) and enhanced beta and gamma activity, but these changes were not age-dependent [5].…”

Section: Introductionmentioning

confidence: 99%

“…The APP/PS1 mice showed reduced cortical theta activity (5 Hz) and enhanced beta and gamma activity, but these changes were not age-dependent [5]. Sánchez-Alavez and coworkers have recently addressed the question whether a secreted form of APP (sAPP) modulates electrophysiological and cerebrovascular processes in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Animal model of Alzheimer’s disease: characteristics of EEG and memory

Mugantseva

Podolski

2009

Open Life Sciences

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Abstract:We studied the effects of aggregated amyloid β-peptide Аβ 25-35 on spatial memory and the spectral-correlational characteristics of EEG of both the dorsal hippocampus and the frontal cortex both in adult and aged rats at the early stage of Аβ 25-35 action. Spatial memory was characterized using a novel cognitive test. A decrease in low-frequency theta band oscillations in the dorsal hippocampus and the frontal cortex was observed. The mean coefficient of EEG cross-correlation between these structures was significantly reduced at the early stage of Aβ 25-35 action both in adult and aged rats. In addition, we found that one month after Aβ 25-35 injection spatial memory was impaired. These results suggest that the decrease in low-frequency theta band oscillations and the weakening of binding between the dorsal hippocampus and the frontal cortex under the action of Аβ 25-35 may be an underlying cause of the typical memory breakdown associated with the Alzheimer's disease.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Animal model of Alzheimer’s disease: characteristics of EEG and memory

Mugantseva

Podolski

2009

Open Life Sciences

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“…Even though the genetic background and expression levels of hAPPwt transgene differ from those of Ts65Dn mice, we hypothesize that this candidate could be involved in the generation of increased theta power and increased wakefulness in Ts65Dn mice. Other authors have found changes in EEG theta power in Tg2576, mice overexpressing App with the Swedish mutation (Wang et al, 2002, Wisor et al, 2005, Zhang et al, 2005. Of note, however, those studies have been using different experimental protocol (EEG derivations and behavioral assessment) and have been focusing on older age.…”

Section: Discussionmentioning

confidence: 99%

Sleep and EEG features in genetic models of Down syndrome

Colas

Valletta

Takimoto-Kimura

et al. 2008

Neurobiology of Disease

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Down syndrome is characterized by a host of behavioral abnormalities including sleep disturbances. Sleep and EEG was studied at the age of 3 months in two mouse models of the condition, Ts65Dn and Ts1Cje, carrying one extra copy of partially overlapping segments of the mmu chromosome 16 (equivalent to the human chromosome 21). We found that the Ts65Dn mice showed increased waking amounts at the expense of non-REM sleep, increased theta power during sleep and a delayed sleep rebound after sleep deprivation. In contrast, Ts1Cje had limited sleep and EEG abnormalities, showing only a delayed sleep rebound after sleep deprivation and no difference in theta power. We previously found that mice over-expressing the human APPwt transgene, a gene triplicated in Ts65Dn but not Ts1Cje, also show increased wake and theta power during sleep. These results demonstrate abnormalities in sleep and EEG in Ts65Dn mice and underscore a possible correlation between App overexpression and hippocampal theta oscillations.

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Beta‐amyloid protein (25–35) disrupts hippocampal network activity: Role of Fyn‐kinase

et al. 2009

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Early cognitive deficit characteristic of early Alzheimer's disease seems to be produced by the soluble forms of beta-amyloid protein. Such cognitive deficit correlates with neuronal network dysfunction that is reflected as alterations in the electroencephalogram of both Alzheimer patients and transgenic murine models of such disease. Correspondingly, recent studies have demonstrated that chronic exposure to betaAP affects hippocampal oscillatory properties. However, it is still unclear if such neuronal network dysfunction results from a direct action of betaAP on the hippocampal circuit or it is secondary to the chronic presence of the protein in the brain. Therefore, we aimed to explore the effect of acute exposure to betaAP(25-35) on hippocampal network activity both in vitro and in vivo, as well as on intrinsic and synaptic properties of hippocampal neurons. We found that betaAP(25-35), reversibly, affects spontaneous hippocampal population activity in vitro. Such effect is not produced by the inverse sequence betaAP(35-25) and is reproduced by the full-length peptide betaAP(1-42). Correspondingly betaAP(25-35), but not the inverse sequence betaAP(35-25), reduces theta-like activity recorded from the hippocampus in vivo. The betaAP(25-35)-induced disruption in hippocampal network activity correlates with a reduction in spontaneous neuronal activity and synaptic transmission, as well as with an inhibition in the subthreshold oscillations produced by pyramidal neurons in vitro. Finally, we studied the involvement of Fyn-kinase on the betaAP(25-35)-induced disruption in hippocampal network activity in vitro. Interestingly, we found that such phenomenon is not observed in slices obtained from Fyn-knockout mice. In conclusion, our data suggest that betaAP acutely affects proper hippocampal function through a Fyn-dependent mechanism. We propose that such alteration might be related to the cognitive impairment observed, at least, during the early phases of Alzheimer's disease.

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Alteration of cortical EEG in mice carrying mutated human APP transgene

Cited by 54 publications

References 31 publications

Animal model of Alzheimer’s disease: characteristics of EEG and memory

Animal model of Alzheimer’s disease: characteristics of EEG and memory

Sleep and EEG features in genetic models of Down syndrome

Beta‐amyloid protein (25–35) disrupts hippocampal network activity: Role of Fyn‐kinase

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