Alteration of baroreflex sensitivity in the elderly: The relationship with metabolic syndrome components

Assoumou, Hourfil-Gabin Ntougou; Bertholon, Frédérique; Barthélémy, Jean‐Claude; Pichot, Vincent; Celle, Sébastien; Gosse, Philippe; Gaspoz, Jean‐Michel; Roche, Frédéric

doi:10.1016/j.ijcard.2011.12.050

Cited by 9 publications

(10 citation statements)

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“…Spectral analysis and BRS were analysed by means of a purposely laboratory‐made program written with MATLAB ® software (Version 7·9·1 R2009b) (Costes et al ., ; Assoumou et al ., ; Dauphinot et al ., ; Fontolliet et al ., ).…”

Section: Experimental Methodsmentioning

confidence: 99%

“…For each subject, the mean slope of the RR versus SAP relationships was then computed and taken as a measure of individual BRS, at rest and at exercise, respectively. Spectral analysis and BRS were analysed by means of a purposely laboratory-made program written with MATLAB â software (Version 7Á9Á1 R2009b) (Costes et al, 2004;Assoumou et al, 2012;Dauphinot et al, 2013;Fontolliet et al, 2015).…”

Section: Data Treatmentmentioning

confidence: 99%

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Heart rate variability and baroreflex sensitivity in bilateral lung transplant recipients

Fontolliet

Gianella

Pichot

et al. 2018

Clin Physio Funct Imaging

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The effects of lung afferents denervation on cardiovascular regulation can be assessed on bilateral lung transplantation patients. The high-frequency component of heart rate variability is known to be synchronous with breathing frequency. Then, if heart beat is neurally modulated by breathing frequency, we may expect disappearance of high frequency of heart rate variability in bilateral lung transplantation patients. On 11 patients and 11 matching healthy controls, we measured R-R interval (electrocardiography), blood pressure (Portapres ) and breathing frequency (ultrasonic device) in supine rest, during 10-min free breathing, 10-min cadenced breathing (0·25 Hz) and 5-min handgrip. We analysed heart rate variability and spontaneous variability of arterial blood pressure, by power spectral analysis, and baroreflex sensitivity, by the sequence method. Concerning heart rate variability, with respect to controls, transplant recipients had lower total power and lower low- and high-frequency power. The low-frequency/high-frequency ratio was higher. Concerning systolic, diastolic and mean arterial pressure variability, transplant recipients had lower total power (only for cadenced breathing), low frequency and low-frequency/high-frequency ratio during free and cadenced breathing. Baroreflex sensitivity was decreased. Denervated lungs induced strong heart rate variability reduction. The higher low-frequency/high-frequency ratio suggested that the total power drop was mostly due to high frequency. These results support the hypothesis that neural modulation from lung afferents contributes to the high frequency of heart rate variability.

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Section: Experimental Methodsmentioning

confidence: 99%

Section: Data Treatmentmentioning

confidence: 99%

Heart rate variability and baroreflex sensitivity in bilateral lung transplant recipients

Fontolliet

Gianella

Pichot

et al. 2018

Clin Physio Funct Imaging

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“…In general, the overlap of several risk factors seems to be stronger in predicting the pathophysiological alterations related to attenuation of BRS as well as to EEBP response. Assoumou et al (2012) have shown that decreased BRS slope was significantly correlated with MetS. Nevertheless, this association also independently was found for triglycerides and waist circumference in elderly patients with MetS ( Assoumou et al, 2012 ).…”

Section: Discussionmentioning

confidence: 93%

“… Assoumou et al (2012) have shown that decreased BRS slope was significantly correlated with MetS. Nevertheless, this association also independently was found for triglycerides and waist circumference in elderly patients with MetS ( Assoumou et al, 2012 ).…”

Section: Discussionmentioning

confidence: 93%

“…When hypertension is eliminated, controversy remains regarding the pathophysiological change and the EEBP response. In addition, only a few studies have focused on the effects of MetS on BRS ( Grassi et al, 2005 ; Trombetta et al, 2010 ; Assoumou et al, 2012 ; Sharman et al, 2018 ). Sharman et al (2018) demonstrated that impaired BRS, but not carotid stiffness, was independently associated with exaggerated exercise BP among those with well-controlled resting BP.…”

Section: Discussionmentioning

confidence: 99%

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Exaggerated Exercise Blood Pressure as a Marker of Baroreflex Dysfunction in Normotensive Metabolic Syndrome Patients

et al. 2021

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IntroductionExaggerated blood pressure response to exercise (EEBP = SBP ≥ 190 mmHg for women and ≥210 mmHg for men) during cardiopulmonary exercise test (CPET) is a predictor of cardiovascular risk. Sympathetic hyperactivation and decreased baroreflex sensitivity (BRS) seem to be involved in the progression of metabolic syndrome (MetS) to cardiovascular disease.ObjectiveTo test the hypotheses: (1) MetS patients within normal clinical blood pressure (BP) may present EEBP response to maximal exercise and (2) increased muscle sympathetic nerve activity (MSNA) and reduced BRS are associated with this impairment.MethodsWe selected MetS (ATP III) patients with normal BP (MetS_NT, n = 27, 59.3% males, 46.1 ± 7.2 years) and a control group without MetS (C, n = 19, 48.4 ± 7.4 years). We evaluated BRS for increases (BRS+) and decreases (BRS−) in spontaneous BP and HR fluctuations, MSNA (microneurography), BP from ambulatory blood pressure monitoring (ABPM), and auscultatory BP during CPET.ResultsNormotensive MetS (MetS_NT) had higher body mass index and impairment in all MetS risk factors when compared to the C group. MetS_NT had higher peak systolic BP (SBP) (195 ± 17 vs. 177 ± 24 mmHg, P = 0.007) and diastolic BP (91 ± 11 vs. 79 ± 10 mmHg, P = 0.001) during CPET than C. Additionally, we found that MetS patients with normal BP had lower spontaneous BRS− (9.6 ± 3.3 vs. 12.2 ± 4.9 ms/mmHg, P = 0.044) and higher levels of MSNA (29 ± 6 vs. 18 ± 4 bursts/min, P < 0.001) compared to C. Interestingly, 10 out of 27 MetS_NT (37%) showed EEBP (MetS_NT+), whereas 2 out of 19 C (10.5%) presented (P = 0.044). The subgroup of MetS_NT with EEBP (MetS_NT+, n = 10) had similar MSNA (P = 0.437), but lower BRS+ (P = 0.039) and BRS− (P = 0.039) compared with the subgroup without EEBP (MetS_NT−, n = 17). Either office BP or BP from ABPM was similar between subgroups MetS_NT+ and MetS_NT−, regardless of EEBP response. In the MetS_NT+ subgroup, there was an association of peak SBP with BRS− (R = −0.70; P = 0.02), triglycerides with peak SBP during CPET (R = 0.66; P = 0.039), and of triglycerides with BRS− (R = 0.71; P = 0.022).ConclusionNormotensive MetS patients already presented higher peak systolic and diastolic BP during maximal exercise, in addition to sympathetic hyperactivation and decreased baroreflex sensitivity. The EEBP in MetS_NT with apparent well-controlled BP may indicate a potential depressed neural baroreflex function, predisposing these patients to increased cardiovascular risk.

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Effects of gravitational acceleration on cardiovascular autonomic control in resting humans

et al. 2015

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Alteration of baroreflex sensitivity in the elderly: The relationship with metabolic syndrome components

Cited by 9 publications

References 10 publications

Heart rate variability and baroreflex sensitivity in bilateral lung transplant recipients

Heart rate variability and baroreflex sensitivity in bilateral lung transplant recipients

Exaggerated Exercise Blood Pressure as a Marker of Baroreflex Dysfunction in Normotensive Metabolic Syndrome Patients

Effects of gravitational acceleration on cardiovascular autonomic control in resting humans

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