Alteration in parotid salivary flow in diabetes mellitus

Conner, Spencer; Iranpour, B; Mills, J.

doi:10.1016/0030-4220(70)90011-3

Cited by 77 publications

(37 citation statements)

References 11 publications

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“…This might result from decreased salivary flow in diabetes, due to hypofunction of the salivary glands secondary to adverse hormonal, microvascular, and neuronal changes (3,19).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oral mucosa epithelium in type II diabetic patients by an exfoliative cytology method

et al. 2008

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Diabetes mellitus is a common metabolic disease that causes chronic hyperglycemia and disturbances in carbohydrate, lipid, and protein metabolism. Although diabetes can cause considerable cellular changes, this field has attracted little research. We therefore decided to evaluate the quantitative and qualitative changes in oral epithelial cells using an exfoliative cytology method. In 30 control individuals and 30 patients with type II diabetes, smears were obtained from two distinct oral sites: the buccal mucosa and tongue dorsum. The oral smears were stained using Papanicolaou solution. Quantitative and qualitative changes were evaluated in each slide. For this purpose, 50 clearly defined cells in each slide were microscopically evaluated, and photographs were subjected to computerized morphometric analysis. Cytoplasmic and nuclear areas in the diabetic group were significantly higher than in the control group. The cytoplasmic/nuclear ratio was lower in the control group. At both smear sites, the proportion of cells with nuclear changes was higher in the diabetic group. Diabetes mellitus can cause alterations in the oral epithelium that are detectable with this exfoliative cytology method. The method may be viable in evaluating this disease. (J. Oral Sci. 50, [335][336][337][338][339][340] 2008)

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“…This might result from decreased salivary flow in diabetes, due to hypofunction of the salivary glands secondary to adverse hormonal, microvascular, and neuronal changes (3,19).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oral mucosa epithelium in type II diabetic patients by an exfoliative cytology method

et al. 2008

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“…Prolonged xerostomia predisposes to local accumulation of plaque and debris and may contribute to the development of opportunistic oral infections, altered taste 57,58 , oral malodour and oral mucosal soreness.…”

Section: Xerostomiamentioning

confidence: 99%

Different oral manifestations of diabetes mellitus and its complications a review

Kadiyala¹,

Kumar²

2017

Int j curr adv res

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Objective: To relate different oral manifestations and oral complications of diabetes mellitus Background: Diabetes mellitus is a chronic lifestyle disease affecting all age groups. It is one of the leading causes of mortality and morbidity worldwide. The term "diabetes mellitus" describes a group of disorders characterised by elevated levels of glucose in the blood and abnormalities of carbohydrate, fat and protein metabolism. A number of oral diseases and disorders have been associated with diabetes mellitus, and periodontitis has been identified as a possible risk factor for poor metabolic control in subjects with diabetes. The article will speak in depth about the complications of diabetes mellitus. This article aims to review and increase the awareness of oral manifestations and complications of diabetes mellitus and to stimulate research on the subject. Reason: It is important to know the different oral manifestations of diabetes mellitus to prevent its complications at the early stages. INTRODUCTIONDiabetes mellitus is a growing public health concern and a common chronic metabolic disease worldwide [1][2][3][4] . Diabetes mellitus represents a group of metabolic diseases that are characterised by hyperglycaemia due to a total or relative lack of insulin secretion and insulin resistance or both. The metabolic abnormalities involve carbohydrate, protein and fat metabolism. Diabetes mellitus affects all age groups, but is more common in adults. The World Health Organization (WHO) has recently declared it to be a pandemic 2 . Its prevalence has increased dramatically over the past few decades and it is expected to triple in the next decade. Diabetes mellitus is considered a leading cause of death due to its microvascular and macrovascular complications 5,6 . The most common types of diabetes are type 1 (insulin dependent) and type 2 (non-insulin-dependent) 7,8 . Type 2 is the more prevalent type. Countries with the highest rates of diabetes in the Eastern Mediterranean region and the Middle East are the United Arab Emirates, Saudi Arabia, Bahrain, Kuwait and Oman 9. Oman is one of the countries that has a high prevalence of diabetes mellitus, especially type 2 diabetes, and its prevalence is expected to increase in the next twenty years 10,11 .Various inflammatory diseases and soft tissue pathologies in oral cavities are associated with diabetes mellitus [12][13][14] . However, awareness of these complications is lacking worldwide [15][16][17][18] . Periodontal diseases have been proposed as the sixth most prevalent complication of diabetes mellitus following the other diabetic complications 19 . It has been reported as a more frequent oral complication of diabetes compared to other oral manifestations such as dry mouth and caries. Periodontitis is more frequent and severe in patients with diabetes with poor glycaemic control. Early identification and/or management of these oral manifestations may help in the early diagnosis of diabetes and in attaining better glycaemic control 20 . Therefore, diabetic oral c...

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“…These alterations may be linked to salivary gland dysfunctions, such as reduced salivary flow rate (48) and altered composition of the saliva, e.g., increased glucose concentration (49).…”

Section: Sglts and Diabetesmentioning

confidence: 99%