Alteration in Cobalt Absorption in Patients with Disorders of Iron Metabolism

Valberg, L. S.; Ludwig, John D.; Olatunbosun, D. A.

doi:10.1016/s0016-5085(69)80123-x

Cited by 70 publications

(16 citation statements)

References 13 publications

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“…several metals can be transported by divalent metal transporter-1 (DMT1) [18,19]. Several studies have reported that iron deficiency may lead to increased absorption of other metals including cobalt and lead [20][21][22]. Our results indicate that the negative iron balance caused by bloodlettings may have a similar effect.…”

Section: Resultsmentioning

confidence: 54%

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bolann

Distante

Mørkrid

et al. 2015

Journal of Trace Elements in Medicine and Biology

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Section: Resultsmentioning

confidence: 54%

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bolann

Distante

Mørkrid

et al. 2015

Journal of Trace Elements in Medicine and Biology

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“…In an iron-deficient animal, numerous binding sites are presumably available to any metal using the same transfer proteins as iron. However, it has been shown (Pollack et al 1965, Valberg et al 1969 1) that iron deficiency does not result in increased absorption of all metals. Consequently, actinides with oxidation states that differ from that of Pu may not, under physiological conditions, use the iron transport system as efficiently as Pu.…”

Section: Introductionmentioning

confidence: 99%

Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm From the Gastrointestinal Tracts of Rats Fed an Iron-Deficient Diet

Sullivan¹,

Ruemmler²

1988

Health Physics

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Absorption of U, Np, Am and Cm was increased by factors of 3.4, 7.1, 2.7 and 1.7, respectively, when nitrate solutions of these actinides were gavaged to adult rats fed an iron-deficient diet. Retention increased proportionately in liver, kidney and carcass. The concentration of the actinides excreted also increased substantially (over that of controls) in the urine of iron-deficient rats gavaged with 233U and 237Np, but not in those with 241Am or 244Cm. Weanling rats on an iron-deficient diet, gavaged with ferric nitrate immediately before administration of 238Pu nitrate, retained between 4% and 12% of the 238Pu retained by litter mates that were not treated intragastrically with iron.

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“…This phenomenon may be a general response of E. grucilis or other cells to metal deprivation. Metal accumulation associated with Zn-deficiency has previously been observed in Euglena (9) as well as in Fe-deficient rats (19), mice ( 14), and humans (26). The biochemical mechanisms underlying this phenomenon are unclear but, among many possibilities, could involve synthesis and secretion of metal-binding ligands such as the hydroxamates and catecholates used by bacteria to assist in Fe uptake (1 8).…”

Section: Resultsmentioning

confidence: 99%

“…Deficiencies in these metals result in a number of pathological disorders. Iron-deficiency causes anemia (26) and altered mitochondria1 structure in animals (6, 7, 16), chlorosis of plants (23), a n d filamentous growth of Esch- To whom correspondence should be sent.…”

mentioning

confidence: 99%

Effects of Iron‐, Manganese‐, or Magnesium‐Deficiency on the Growth and Morphology of Euglena gracilis1

Hilt¹,

Gordon²,

Hein

et al. 1987

The Journal of Protozoology

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Iron-, manganese-, or magnesium-deficiency has been induced in Euglena gracilis. Each arrests cell proliferation, decreases the intracellular content of the deficient metal, and increases that of several other metals. Light and electron microscopy of stationary phase cells reveal that Fe-deficient (-Fe) cells are similar in size and shape to control organisms. Magnesium-deficient (-Mg) cells, however, are larger, and approximately 14% are multilobed, containing 2 to 12 lobes of equal size emanating from a central region. Individual (-Mg) cells and each lobe of multilobed cells contain a single nucleus. Manganese-deficient (-Mn) organisms are morphologically more heterogeneous than (-Fe) or (-Mg) cells. Most are spherical and larger than controls. Approximately 15% are multilobed but, unlike (-Mg) cells, contain lobes of unequal size with either zero, one, or several nuclei present in each. Nuclei of (-Mn) cells differ in size and shape from those of control, (-Fe), or (-Mg) cells. All three deficient cell types accumulate large quantities of paramylon. Other cytoplasmic structures, however, appear normal. Addition of Fe, Mn, or Mg to the respective deficient stationary phase cultures reverses growth arrest and restores normal morphology. The results suggest that Fe-, Mn-, and Mg-deficiencies affect different stages of the E. gracilis cell cycle.

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Alteration in Cobalt Absorption in Patients with Disorders of Iron Metabolism

Cited by 70 publications

References 13 publications

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm From the Gastrointestinal Tracts of Rats Fed an Iron-Deficient Diet

Effects of Iron‐, Manganese‐, or Magnesium‐Deficiency on the Growth and Morphology of Euglena gracilis1

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