Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bolann, Bjørn J.; Distante, S; Mørkrid, Lars; Ulvik, Rune J.

doi:10.1016/j.jtemb.2014.07.021

Cited by 6 publications

(8 citation statements)

References 37 publications

(40 reference statements)

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“…The reason for this discrepancy is not clear. Beyond these and our previous study [22], we have found no other report on the effects of bloodlettings on trace element status in hemochromatosis patients.…”

Section: Introductioncontrasting

confidence: 77%

Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations

Yazdani

Distante

Mørkrid

et al. 2022

Biol Trace Elem Res

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Hemochromatosis is a hereditary disorder, most often associated with mutations of the HFE (High FErrum) gene. If left untreated, it can result in severe parenchymal iron accumulation. Bloodletting is the mainstay treatment. We have previously shown that treatment of hemochromatosis by repeated bloodlettings may induce changes in the serum levels of several trace elements. The aim of this work was to evaluate if whole blood concentrations of the environmental pollutants lead (Pb), mercury (Hg), and cadmium (Cd) could be affected by bloodlettings. We recruited 28 patients and 21 healthy individuals (control group). Whole blood and urine levels of Pb, Hg, and Cd were measured before the start and after the completion of treatment using inductively coupled plasma mass spectrometry, together with serum iron and liver function tests. Concentrations of blood Pb, but not Hg or Cd, were significantly increased after treatment. The increase in Pb was higher in C282Y homozygous patients than in the other patients, and it was positively correlated with the serum concentration of alkaline phosphatase. Bloodlettings in hemochromatosis result in an increase in the blood concentration of Pb. Augmented absorption due to iron loss or Pb mobilization from bone may contribute to the higher blood Pb level.

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Section: Introductioncontrasting

confidence: 77%

Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations

Yazdani

Distante

Mørkrid

et al. 2022

Biol Trace Elem Res

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“…Five-hundred μL of whole blood and serum was aliquoted and stored at –80°C until analysis. Whole blood Hg, Pb and Cd and serum Sb were analyzed by ICP-MS on Perkin Elmer DRC-e (Perkin Elmer®, USA) in standard mode [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Predictors of mercury, lead, cadmium and antimony status in Norwegian never-pregnant women of fertile age

et al. 2017

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BackgroundThe toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of toxic trace elements in never-pregnant women of fertile age is of concern.MethodsHealthy, never-pregnant women aged 18 to 40 years (n = 158) were recruited between June 2012 and March 2015 in Bergen, Norway. Clinical data were collected and non-fasting venous blood samples were analyzed for whole blood Hg, Pb and Cd and serum Sb by ICP-MS and related to diet and life style factors.ResultsIn a multiple linear regression model, increasing age was associated with higher levels of Hg and Sb, but diet and life style factors were more important predictors. Median whole blood Hg was increased by a factor of 70 in women who had fish for dinner ≥1/week, compared to women who rarely or never ate fish (p<0.001). Alcohol intake was the strongest predictor for whole blood Pb, while use of tobacco was the strongest predictor for whole blood Cd. Being a vegetarian was associated with lower levels of both Hg and Sb.ConclusionsAs toxic trace elements tend to bioaccumulate in the body, increasing maternal age at delivery may represent a threat to the next generation. In a group of healthy Norwegian never-pregnant women, age contributed to Hg and Sb levels, but diet and life style factors were stronger determinants of whole blood Hg, Pb, Cd and serum Sb levels. Continuous public actions are needed to reduce modifiable and preventable sources of potentially deleterious toxins to minimize the exposure in children and fertile women.

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“…A complete set of blood samples was available for all, except nine women and 16 infants. Selenium in serum was measured by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) on Elan ® Dynamic Reaction Cell-e (Perkin Elmer MDS Sciex, Concord, ON, Canada) in standard mode [17]. The serum samples were diluted 1:15 with dilution solution containing 1% Triton ® X-100 (Merck, Damstadt, Germany) 0.33% w/v pro analysis HNO 3 (Merck, Germany), and 5 ppm Gold (Perkin Elmer, Shelton, CT, USA).…”

Section: Methodsmentioning

confidence: 99%

Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life

et al. 2017

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Pregnant women and infants are at risk for selenium deficiency, which is known to have negative effects on immune and brain function. We have investigated selenium levels in 158 healthy never-pregnant women and in 114 pregnant and lactating women and their infants at age 6 months and related this to clinical outcomes during the first 6 months of life. Neurodevelopment was assessed with the parental questionnaire Ages and Stages (ASQ) at 6 months. A maternal selenium level ≤0.90 µmol/L in pregnancy week 18 was negatively related to infant neurodevelopment at 6 months (B = −20, p = 0.01), whereas a selenium level ≤0.78 µmol/L in pregnancy week 36 was associated with an increased risk (odds ratio 4.8) of having an infant infection during the first 6 weeks of life. A low maternal selenium status in pregnancy was found to be associated with an increased risk of infant infection during the first 6 weeks of life and a lower psychomotor score at 6 months. We suggest a cutoff for maternal serum selenium deficiency of 0.90 µmol/L in pregnancy week 18 and 0.78 µmol/L in pregnancy week 36. This should be reevaluated in an intervention study.

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Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Cited by 6 publications

References 37 publications

Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations

Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations

Predictors of mercury, lead, cadmium and antimony status in Norwegian never-pregnant women of fertile age

Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life

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