Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wistar rats

Shittu, Oluwatosin Kudirat; Lawal, Bashir; Alozieuwa, Blessing U.; Haruna, Garba Muhammed; Abubakar, Abdulkadir; Berinyuy, Eustace Bonghan

doi:10.1016/s2222-1808(15)60907-0

Cited by 46 publications

(51 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The kidneys regulate the excretion of urea and reabsorption of electrolytes into the blood. During glomerular impairment, urea and creatinine accumulate in the biological fluid [46]. In the present study, the significant alterations in serum urea and creatinine concentrations following the administration of the extract could be due renal dysfunction.…”

Section: Discussionmentioning

confidence: 51%

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background: Zingiber officinale is a rhizome commonly consumed as a delicacy, medicine or spice. It is considered as a safe spice with several medicinal properties. The aim of this study was to evaluate in-vitro antioxidants, antimicrobial and safety of Nigerian Z. Officinale. Methods: Methanol extract of Nigerian Z. Officinale (MEZO) was evaluated for phytochemical composition, total flavonoids and phenol contents using standard procedures. Antibacterial study was carried out via the agar well diffusion method. Antioxidant activities were carried out using 2, 2′-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant properties (FRAP) assay. Twenty five (25) wister rats were randomly grouped into five (A-E) of five animals each. Animals in Groups AD were orally administered 75,150, 300 and 600 mg/kg bwt of the extract on daily basis for 4 weeks while those in Group A (control) received distilled water. Results: Total phenolic and flavonoids contents of the extract were 15.24 ± 0.02 mg GAE/g and 19.84 ± 0. 32 mg/g CE respectively. The extract promoted an inhibition of free radicals with IC 50 values of 47.05 ± 2. 03 μg/mL and 89.15 ± 0.29 μg/mL in DPPH and FRAP assay. At extract concentration of 100 μg/mL, K. pneumoniae showed the highest susceptibility of 29.04 ± 0.35 mm, followed by P. aeuruginisa (26.03 ± 0.41 mm), while S. aureus (15.08 ± 0.20 mm) was least susceptible. The serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), sodium, albumin, total proteins and the computed organs/body weight ratios compared favorably (p > 0.05) with control at all extract doses tested. The bilirubin, urea and creatinine levels significantly (p < 0.05) increase while chloride decreases in rats dosed 600 mg/kg bwt. However, potassium level increases significantly (p < 0.05) in rats dose 300 mg/kg of the extract when compare with the control. Conclusion: This study revealed the strong antioxidant and antimicrobial potentials of methanol extract of Nigerian Zingiber officinale. It was also found to be relatively safe for consumption and thus could serve as a source of candidate for the development of new antioxidants and antimicrobial drugs.

show abstract

Section: Discussionmentioning

confidence: 51%

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Evaluations of biochemical parameters including aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total proteins, albumins, bilirubins, super oxide dismutase (SOD), catalase, malondialdehyde (MDA), glutathione peroxidase have been widely used in assessing the integrity of the liver [33][34][35][36][37]. Therefore, the hepatoprotective capacities of natural products reviewed in this study were assessed based on the levels of ameliorative effect on hapatotoxicants induced alterations in level of these biochemical parameters (Table 8).…”

Section: Resultsmentioning

confidence: 99%

African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

Self Cite

View full text Add to dashboard Cite

Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

show abstract

“…The protective effect of propolis on liver against oxidative damage was previously recorded by Salman et al 46 in rats exposed to γ-irradiation and clarify that propolis have a modulatory role against the cellular damage produced by free radicals induced by ionizing radiation. Shittu et al 47 mentioned that propolis has ameliorated the adverse effects of carbon tetrachloride induced liver damage and could therefore, be recommended as an effective natural product for the management of liver disease. Seven et al 48 proposed that propolis ameliorate the hepatotoxicity of cyclosporine A by scavenging the free radicals and increasing the antioxidant activities.…”

Section: Liver Function Parametersmentioning

confidence: 99%

Assessment of Beneficial Effect of Propolis against Cadmium Induced Toxicity and Oxidative Stress in Rats.

2017

JCBSC

View full text Add to dashboard Cite

Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wistar rats

Cited by 46 publications

References 10 publications

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

African natural products with potential antioxidants and hepatoprotectives properties: a review

Assessment of Beneficial Effect of Propolis against Cadmium Induced Toxicity and Oxidative Stress in Rats.

Contact Info

Product

Resources

About