Alterações do TSH em pacientes com síndrome de Down: uma interpretação nem sempre fácil

Autoantibodies in patients with Down Syndrome: Early senescence of the immune system or precocious markers for immunological diseases?

“…Celiac disease has been previously confirmed in 6.9% of the DS patients of the present study, 9 while thyroid dysfunction was detected in 42.9% of them, with the presence of anti‐peroxidase antibodies in 15.3% 20 . These data were in agreement with worldwide reports and reinforce the high association of these autoimmune diseases with DS.…”

Down syndrome in adults: success and challenge

“…A high prevalence of thyroid disease associated with changes in serum levels of thyroid stimulating hormone (TSH) and anti-thyroid peroxidase (anti-TPO) antibodies has also been reported, particularly in individuals above 9 years of age. 12 Regular assessment of thyroid function is recommended in patients with DS to reduce obesity and cognitive deficits in this population. 13,14 Similar attention should be paid to glycemic changes, particularly type I diabetes mellitus, given that the prevalence of diabetes in patients with DS is approximately four times higher than that in the general population.…”

Profile of physiotherapy intervention for Down syndrome children

“…Metabolic questions cited by three of the participants also must be investigated, as thyroid alterations, when early diagnosed and treated direct bene its for physical and intellectual development of DS children (33). Tests for vision, hearing, heart, metabolic dosages, and orthopaedic anomalies are important to be considered by the physiotherapist, as means of minimizing developmental anomalies of DS children.…”