Alteraciones endocrinológicas en 1.105 niños y adolescentes con síndrome de Down

Regueras, L.; Prieto, Pablo; Muñoz-Calvo, M.T.; Pozo, Juan Ignacio; Arguinzoniz, Lissette; Argente, Jesús

doi:10.1016/j.medcli.2010.06.029

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…Thyroid disorders are more common in patients with DS than in the general population and they have been estimated to range between 4 and 19.5% [4,5,6,7,8] with an increase in frequency, up to 54%, as the children age [5,9,10]. These abnormalities include congenital hypothyroidism (1-3.6%) [7,11,12,13,14], primary hypothyroidism (0.3-3.2%) [7,14,15], autoimmune thyroiditis (0.3-1.4%) [16], and subclinical hypothyroidism (12.5-32.9%) [7,10,14,15,17]. In addition, hyperthyroidism (0-2%) occurs in children with DS as well [7,10,18].…”

Section: Introductionmentioning

confidence: 99%

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Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

et al. 2014

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Background/Aims: The natural history of thyroid function in children with Down's syndrome is relatively unknown. We hypothesized that in these patients the occurrence of thyroid dysfunction rises during development. Methods: Thyroid function was assessed yearly in 145 children with Down's syndrome, all followed from birth up to 10 years of age. Heteroskedastic binary and ordinary logistic regression for repeated measures was used to evaluate the relationship of thyroid function with continuous time. Results: Congenital hypothyroidism was detected in 7% of cases. The probability of acquired thyroid dysfunction increased from 30% at birth to 49% at 10 years (p < 0.001). The subclinical hypothyroidism was nearly stable during the follow-up. The probability of hypothyroidism increased from 7 to 24% at 10 years (p < 0.001). Positive anti-thyroglobulin antibodies were associated with higher odds of more severe hypothyroidism (odds ratio 3.6). Positive anti-thyroid peroxidase antibodies were a better predictor of more severe hypothyroidism (odds ratio 6.1). Diffuse hypoechogenicity on thyroid ultrasound was found in 34 out of 145 children. Conclusion: The probability of thyroid dysfunction increasing during development is higher than previously reported. Such children should be carefully monitored annually to early identify thyroid dysfunction.

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Section: Introductionmentioning

confidence: 99%

“…These abnormalities include congenital hypothyroidism (1-3.6%) [7,11,12,13,14], primary hypothyroidism (0.3-3.2%) [7,14,15], autoimmune thyroiditis (0.3-1.4%) [16], and subclinical hypothyroidism (12.5-32.9%) [7,10,14,15,17]. In addition, hyperthyroidism (0-2%) occurs in children with DS as well [7,10,18]. …”

Section: Introductionmentioning

confidence: 99%

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

et al. 2014

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“…Subclinical hypothyroidism accounted for 32.9% of all cases. A review of 1105 cases of adolescents with Down's syndrome, analysed retrospectively in Spain, showed 216 with thyroid pathology (19.5%) of whom subclinical primary hypothyroidism was present in 168 cases, congenital primary hypothyroidism in 15, clinical primary hypothyroidism in 24 and hyperthyroidism in 5 cases [6]. In a longitudinal follow up of 85 patients with Down's syndrome in Upssala country up to the age of 25 years with TFT done at each yearly visit, hypothyroidism was documented in 30 patients and hyperthyroidism in 2 [7].…”

Section: Discussionmentioning

confidence: 99%

Hyperthyroidism in Down’s Syndrome – A Report of Two Cases

Saikia¹

2012

Thyroid Disorders

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“…Studies have shown that patients with DS suffer from immunological disturbances, are more susceptible to infections, and have higher risk of neoplasms and autoimmune diseases [ 15 , 16 ]. The most significant relation was detected for DS and autoimmune thyroiditis and CD [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of coeliac disease prevalence in patients with Down syndrome in Poland – a multi-centre study

Szaflarska-Popławska¹,

Soroczyńska-Wrzyszcz²,

Barg³

et al. 2016

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IntroductionThe results of studies assessing whether patients with Down syndrome have increased risk of coeliac disease are contradictory. The prevalence of coeliac disease in patients with Down syndrome is estimated at a wide range between 1% to as much as 18.6%.AimTo assess coeliac disease prevalence in patients with Down syndrome in Poland.Material and methodsThe study enrolled 301 patients with Down syndrome from six centres in Poland (Wroclaw, Sandomierz, Rzeszow, Grudziadz, Katowice, and Bydgoszcz). We measured the concentration of anti-tissue transglutaminase IgA antibodies and anti-deamidated gliadin peptide IgG antibodies in all patients. Patients with abnormal positive (> 10 U/ml) or inconclusive (7–10 U/ml) result of the serological test were offered endoscopic biopsy of the small intestine in the main centre.ResultsIn 31 (10.3%) patients increased concentrations of the investigated antibodies were found, including 19 (6.3%) patients with increased tTg-IgA concentration, 27 (8.97%) patients with increased concentration of DGP-IgG, and 15 (4.98%) patients with increased concentration of both types of antibodies. Endoscopic biopsy of the small intestine was planned for all 31 patients with abnormal results of at least one antibody test and for 2 patients with inconclusive results. One of them suffered from previously diagnosed and histologically confirmed coeliac disease. Biopsy was not conducted in 9 patients due to contraindications, lack of their consent, or introduction of a gluten-free diet by the parents before the examination. In a group of 23 patients who underwent endoscopic biopsy of the small intestine, in 15 patients the histopathological picture of the small intestinal mucosa was typical for coeliac disease, 2 patients were diagnosed with lesions of grade 1 according to the classification by Marsh-Oberhuber, 1 patient was diagnosed with focal shortening of villi and hypertrophy of the crypts with no intraepithelial lymphocytosis (remains under gastrological observation), 2 patients were diagnosed with mucosal inflammation of the duodenum, and 3 patients were found to have a normal histopathological picture of the small intestine. Analysis of the data included in the questionnaires of all patients showed no statistically significant differences in the body height, body mass index, prevalence of abdominal pain, diarrhoea, constipations, recurrent stomatitis, enamel hypoplasia, thyroid diseases, or hypertransaminasaemia between the groups of patients with normal and abnormal serological test results. Significantly higher prevalence of abdominal flatulence (p < 0.05) and epilepsy (p < 0.05) was found in the group of patients whose serological test results were negative.ConclusionsPatients with Down syndrome are a high-risk group for coeliac disease in the Polish population, with an estimated prevalence of at least 5.4%. Serological tools based on tTG-IgA and DGP-IgG tests are useful for the diagnosis of coeliac disease in Down syndrome patients. tTG-IgA test may be superior to DGP-IgG test in pa...

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Alteraciones endocrinológicas en 1.105 niños y adolescentes con síndrome de Down

Cited by 10 publications

References 22 publications

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

Hyperthyroidism in Down’s Syndrome – A Report of Two Cases

Assessment of coeliac disease prevalence in patients with Down syndrome in Poland – a multi-centre study

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