Alstolactines A–C, novel monoterpenoid indole alkaloids from Alstonia scholaris

Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone

“…The 1 H and 13 C NMR spectral data of 2 (Tables 1, 2) were similar to those of alschomine [24], except for the absence of a methoxy group in 2. Thirteen known compounds, picrinine (4) [24], strictamine (5) [25], strictamine N 4 -oxide (6) [26], 5α-methoxylstrictamine (7) [8], akuammidine (8) [27], vallesamine (9) [28], vallesamine N 4 -oxide (10) [28], scholaricine (11) …”

“…In addition, the leaves of A. scholaris induced pronounced bronchodilatory activity in an aesthetized rats [5] and the crude extract of its leaves has also been prescribed in hospitals and sold over the counter in drug stores [6]. In our previous phytochemical studies, a series of monoterpenoid indole alkaloids were isolated from different parts of plant [7][8][9]. Besides, alkaloids from leaf of A. scholaris cultivated in Pu'er, indicated anti-tussive, anti-asthmatic, anti-inflammatory, analgesic and expectorant activities both in vitro and in vivo [10][11][12][13].…”

“…Then, we investigated HPLC fingerprints of alkaloids of A. scholaris from Pu'er and Kunming, and the result exhibited visible difference, which encouraged us to search for structurally unique and biologically active indole alkaloids of A. scholaris from different climate zones. As a result, three new monoterpenoid indole alkaloids, normavacurine-21-one (1), 5-hydroxy-19, 20-E-alschomine (2), and 5-hydroxy-19, 20-Z-alschomine (3), together with thirteen known monoterpenoid indole alkaloids (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16), were…”

Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats

“…The leaves have long been used in "dai" ethno-pharmacy to treat postinfectious cough, chronic bronchitis, asthma, and other respiratory tract infections in Yunnan Province, China [6]. The authors of this paper have investigated intensively the phytochemical constituents of the different parts of the plant [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The chemical profile and metabolites of alkaloidal extract of leaves of A. scholaris indicate that scholaricine, 19-epischolaricine, vallesamine, and picrinine are the major indole alkaloids [27,28].…”

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

“…Its leaves have long been used in "dai" ethno-pharmacy for the treatment of whooping cough (post infectious cough), chronic bronchitis, asthma, and other respiratory tract infections in Yunnan Province, PR China (Compiling Group of Yunnan Traditional Chinese Medicine, 1977). Phytochemical constituents of different parts of the plant were investigated intensively by our group (Cai et al, 2010(Cai et al, , 2008a(Cai et al, , 2008b(Cai et al, , 2007Chen et al, 2016;Du et al, 2007aDu et al, , 2007bFeng et al, 2009Feng et al, , 2008Liu et al, 2015;Pan et al, 2016;Qin et al, 2015aQin et al, , 2015bXu et al, 2009;Yang et al, 2015aYang et al, , 2015bYang et al, , 2014aYang et al, , 2014bZhang et al, 2014;Zhou et al, 2005). Meanwhile, the chemical profiling and metabolites of alkaloidal extract of A. scholaris were reported (Cao et al, 2015), in which scholaricine, 19-epischolaricine, vallesamine, and picrinine were the major indole alkaloids of its leaf ( Fig.…”